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Identification of prenylated pterocarpans and other isoflavonoids in Rhizopus spp. elicited soya bean seedlings by electrospray ionisation mass spectrometry

Autor: Harry Gruppen, Marian A. Verbruggen, Tomas F. M. Kuijpers, Jean-Paul Vincken, Maxime C. Bohin, Rudy Simons

Publikováno v: Rapid Communications in Mass Spectrometry. 25:55-65

Phytoalexins from soya are mainly characterised as prenylated pterocarpans, the glyceollins. Extracts of non-soaked and soaked soya beans, as well as that of soya seedlings, grown in the presence of Rhizopus microsporus var. oryzae, were screened for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d253fcf4c7f10f4efb61709cff25a2b2
https://doi.org/10.1002/rcm.4826

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Efficacy and safety of a flaxseed hull extract in the symptomatic management of benign prostatic hyperplasia: a parallel, randomized, double-blind, placebo-controlled, pilot study

Autor: Rudy Simons, Marian A. Verbruggen, Navneet Sonawane, Jayesh Chaudhary

Publikováno v: Journal of medicinal food. 18(2)

This exploratory study was designed to assess the effectiveness of a lignan-rich extract of flaxseed hulls (LinumLife EXTRA(®)) in alleviating symptoms in subjects with benign prostatic hyperplasia (BPH) compared with placebo. Two dosages of extract

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e090114839e26b3fc51e57bcba40f607
https://pubmed.ncbi.nlm.nih.gov/25546379

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Preventive effects of lignan extract from flax hulls on experimentally induced benign prostate hyperplasia

Autor: Jean-François Bisson, Rudy Simons, Marian A. Verbruggen, Sophie Hidalgo

Publikováno v: Journal of medicinal food. 17(6)

Consumption of diet rich in lignans may decrease the risk of some chronic hormonal conditions such as benign prostatic hyperplasia (BPH). This study investigated whether a lignan-rich extract from flaxseed hulls, LinumLife EXTRA (LLE), could prevent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be76c1987d6d3fcfb3b3cfcd7456f5d
https://pubmed.ncbi.nlm.nih.gov/24460407

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Prenylated isoflavonoids from plants as selective estrogen receptor modulators (phytoSERMs)

Autor: Jean-Paul Vincken, Rudy Simons, Toine F.H. Bovee, Harry Gruppen, Marian A. Verbruggen

Publikováno v: Food & Function 3 (2012) 8
Food & Function, 3(8), 810-827

Isoflavonoids are a class of secondary metabolites, which comprise amongst others the subclasses of isoflavones, isoflavans, pterocarpans and coumestans. Isoflavonoids are abundant in Leguminosae, and many of them can bind to the human estrogen recep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be26e86ce051fe090e58e46d1759b1ae
https://pubmed.ncbi.nlm.nih.gov/22684228

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Increasing soy isoflavonoid content and diversity by simultaneous malting and challenging by a fungus to modulate estrogenicity

Autor: Marian A. Verbruggen, Jean-Paul Vincken, Rudy Simons, Harry Gruppen, Nikolaos Roidos, Martijn van Iersel, Toine F.H. Bovee

Publikováno v: Journal of Agricultural and Food Chemistry 59 (2011) 12
Journal of Agricultural and Food Chemistry, 59(12), 6748-6758

Soybeans were germinated on a kilogram-scale, by the application of malting technology used in the brewing industry, and concomitantly challenged with Rhizopus microsporus var. oryzae. In a time-course experiment, samples were taken every 24 h for 10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d801208a81a2d6ef31d7a402800c8ea9
https://pubmed.ncbi.nlm.nih.gov/21561073

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Identification of prenylated pterocarpans and other isoflavonoids in Rhizopus spp. elicited soya bean seedlings by electrospray ionisation mass spectrometry

Autor: Rudy, Simons, Jean-Paul, Vincken, Maxime C, Bohin, Tomas F M, Kuijpers, Marian A, Verbruggen, Harry, Gruppen

Publikováno v: Rapid communications in mass spectrometry : RCM. 25(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0dc4d13c31de283667c815be02dbfd7c
https://pubmed.ncbi.nlm.nih.gov/21154654

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A rapid screening method for prenylated flavonoids with ultra-high-performance liquid chromatography/electrospray ionisation mass spectrometry in licorice root extracts

Autor: Jean-Paul Vincken, Harry Gruppen, Edwin J. Bakx, Marian A. Verbruggen, Rudy Simons

Publikováno v: Rapid Communications in Mass Spectrometry 23 (2009) 19
Rapid Communications in Mass Spectrometry, 23(19), 3083-3093

Due to their substitution with an isoprenoid group, prenylated flavonoids have an increased affinity for biological membranes and target proteins, enhancing their potential bioactivity. Although many prenylated flavonoids have been described, there a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7ce223614309071f0c3ed1aa23b51d6
https://research.wur.nl/en/publications/a-rapid-screening-method-for-prenylated-flavonoids-with-ultra-hig

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Agonistic and antagonistic estrogens in licorice root (Glycyrrhiza glabra)

Autor: Rudy Simons, Jean-Paul Vincken, Loes A. M. Mol, Susan A. M. The, Toine F. H. Bovee, Teus J. C. Luijendijk, Marian A. Verbruggen, Harry Gruppen

Publikováno v: Analytical and Bioanalytical Chemistry 401 (2011) 1
Analytical and Bioanalytical Chemistry
Analytical and Bioanalytical Chemistry, 401(1), 305-313

The roots of licorice (Glycyrrhiza glabra) are a rich source of flavonoids, in particular, prenylated flavonoids, such as the isoflavan glabridin and the isoflavene glabrene. Fractionation of an ethyl acetate extract from licorice root by centrifugal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4d15877ffe392d4f3fe613eef75b618

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