Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Rudy F. J. J. Duisters"'
Autor:
Jos G. Maessen, Ingeborg van der Made, Stephane Heymans, Viola Lentink, Paul Barenbrug, Anke J. Tijsen, Rick van Leeuwen, Joost J. Leenders, Yigal M. Pinto, Blanche Schroen, Mark W.M. Schellings, Veronica Herias, Esther E. Creemers, Rudy F. J. J. Duisters
Publikováno v:
Circulation research, 104(2), 170-U61. Lippincott Williams and Wilkins
The myocardium of the failing heart undergoes a number of structural alterations, most notably hypertrophy of cardiac myocytes and an increase in extracellular matrix proteins, often seen as primary fibrosis. Connective tissue growth factor (CTGF) is
Autor:
Morten A. Høydal, Michael Schwake, Jacques Debets, Rudy F. J. J. Duisters, Nard Kubben, Ben J. A. Janssen, Mark W.M. Schellings, Stephane Heymans, Mirjam van Loon, Blanche Schroen, Rick van Leeuwen, Anne Bertrand, Yigal M. Pinto, Joost J. Leenders, Paul Saftig, Arie van Erk
Publikováno v:
Journal of experimental medicine, 204(5), 1227-1235. Rockefeller University Press
The Journal of Experimental Medicine
The Journal of Experimental Medicine
The intercalated disc (ID) of cardiac myocytes is emerging as a crucial structure in the heart. Loss of ID proteins like N-cadherin causes lethal cardiac abnormalities, and mutations in ID proteins cause human cardiomyopathy. A comprehensive screen f
Autor:
Blanche Schroen, Marcus Baumann, Carine J. Peutz-Kootstra, Yigal M. Pinto, Suzanne H. P. Janssen, Rick van Leeuwen, Mark W.M. Schellings, Rudy F. J. J. Duisters, Stephane Heymans
Publikováno v:
Hypertension, 47(3), 467-474. Lippincott Williams and Wilkins
Imatinib specifically inhibits receptor tyrosine kinase signaling and is clinically used to treat leukemia. Receptor tyrosine kinases not only mediate tumor growth but also initiate adverse signaling in heart failure. We investigated whether imatinib
Autor:
Chris T. Evelo, Yigal M. Pinto, Rudy F. J. J. Duisters, Harry J.G.M. Crijns, Jos F.M. Smits, Umesh C. Sharma, Jacques Debets, Blanche Schroen, Mat J.A.P. Daemen, Saraswati Pokharel, Jack P.M. Cleutjens, Rick van Leeuwen, Stephane Heymans, Ben J. A. Janssen, Paul Bornstein, J. Gordon Porter, W. Matthijs Blankesteijn
Publikováno v:
Circulation research, 95(5), 515-522. Lippincott Williams and Wilkins
Circulation Research, 95(5), 506-514. Lippincott Williams and Wilkins Ltd.
Circulation Research, 95(5), 506-514. Lippincott Williams and Wilkins Ltd.
Cardiac hypertrophy can lead to heart failure (HF), but it is unpredictable which hypertrophied myocardium will progress to HF. We surmised that apart from hypertrophy-related genes, failure-related genes are expressed before the onset of failure, pe
Autor:
Nard Kubben, Hjgm Crijns, Christopher J. Hutchison, Frans C. S. Ramaekers, R Van Leeuwen, Jos L. V. Broers, J.H. van Berlo, Yigal M. Pinto, Rudy F. J. J. Duisters, Jan Willem Voncken
Publikováno v:
Human molecular genetics, 14(19), 2839-2849. Oxford University Press
Human Molecular Genetics, 14(19), 2839-49. Oxford University Press
Human Molecular Genetics, 14(19), 2839-2849. Oxford University Press
Human Molecular Genetics, 14(19), 2839-49. Oxford University Press
Human Molecular Genetics, 14(19), 2839-2849. Oxford University Press
Diseases caused by mutations in lamins A and C (laminopathies) suggest a crucial role for A-type lamins in different cellular processes. Laminopathies mostly affect tissues of mesenchymal origin. As transforming growth factor-beta 1 (TGF-beta 1) sign