Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ruduwaan Salie"'
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Since antiquity, alternative herbal remedies, such as S. africana caerulea/Blue Sage (BLS) water infusion extract (WIE) has been used by traditional healers, for the effective treatment of various chronic inflammatory disorders associated
Externí odkaz:
https://doaj.org/article/b2d8dc296ff44effb392bf930e73fe77
β3-AR activation contributes partly or may be solely responsible for ensuing cardiac damage in myocardial ischaemia or heart failure. This would largely depend on disease stage, severity, experimental model as well as drug specificities which should
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::428d357bbfdb9c5145b74a1bb7603743
https://doi.org/10.21203/rs.3.rs-982400/v1
https://doi.org/10.21203/rs.3.rs-982400/v1
Publikováno v:
Cardiovascular Drugs and Therapy. 33:163-177
The β3-AR (beta3-adrenergic receptor) is resistant to short-term agonist-promoted desensitization and delivers a constant intracellular signal, making this receptor a potential target in acute myocardial infarction (AMI). To investigate whether sele
Publikováno v:
Molecular and cellular biochemistry. 473(1-2)
We recently reported that non-preconditioned hearts from diet-induced obese rats showed, compared to controls, a significant reduction in infarct size after ischaemia/reperfusion, whilst ischaemic preconditioning was without effect. In view of the hi
Autor:
Kopano Dube, Amanda Lochner, Barbara Huisamen, Karthik Dhanabalan, Marguerite Blignaut, Ruduwaan Salie
Publikováno v:
Heliyon
Heliyon, Vol 5, Iss 10, Pp e02659-(2019)
Heliyon, Vol 5, Iss 10, Pp e02659-(2019)
Research focus recently shifted to mitochondrial dynamics and the role of fusion and fission in cardioprotection. The aim of this study was to evaluate (i) the function and dynamics of mitochondria isolated from hearts exposed to ischaemia/reperfusio
Autor:
Ruduwaan Salie, Peter Waweru Mwangi, Emiliana Imperial, F. Kamau, Dee Blackhurst, Hans Strijdom
Publikováno v:
Vascular pharmacology. 121
Obesity rates are rising in HIV-infected populations; however, the putative role of highly active antiretroviral therapy (HAART) in the development of endothelial and cardiovascular derangements in the presence of pre-existing overweight/obesity is u
Myocardial susceptibility to ischaemia/reperfusion in obesity: a re-evaluation of the effects of age
Autor:
Erna Marais, Ingrid Webster, Amanda Lochner, Barbara Huisamen, W.-J. Fan, Ruduwaan Salie, Gerald J. Maarman
Publikováno v:
BMC Physiology
Background Reports on the effect of age and obesity on myocardial ischaemia/reperfusion (I/R) injury and ischaemic preconditioning are contradictory. The aim of this study was to re-evaluate the effects of age and diet-induced obesity (DIO) on myocar
Publikováno v:
Cardiovascular therapeutics. 35(3)
Exposure of the heart to 5 min global ischaemia (I) followed by 5 min reperfusion (R) (ischaemic preconditioning, IPC) or transient Beta 2-adrenergic receptor (B2-AR) stimulation with formoterol (B2PC), followed by 5 min washout before index ischaemi
Publikováno v:
Cardiovascular Drugs and Therapy. 25:31-46
To determine the mechanism whereby transient stimulation of the β-adrenergic receptor subtypes (β-AR) elicit cardioprotection against subsequent ischaemia. Isolated rat hearts were subjected to 35 min regional ischaemia (RI) and reperfusion and inf
Publikováno v:
Metabolic Brain Disease. 16:175-185
The mitogen-activated protein kinase (MAP kinase) pathway participates in a number of reactions of the cell when responding to various external stimuli. These stimuli include growth factor binding to its receptor as well as stressful situations such