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pro vyhledávání: '"Rudra, KR"'
Autor:
Phillips, MA, White, KL, Kokkonda, S, Deng, X, White, J, El Mazouni, F, Marsh, KC, Tomchick, DR, Manjalanagara, K, Rudra, KR, Wirjanata, G, Noviyanti, R, Price, R, Marfurt, J, Shackleford, DM, Chiu, FCK, Campbell, M, Jimenez Diaz, MB, Ferrer-Bazaga, S, Angulo-Barturen, I, Martínez-Martínez, MS, Lafuente-Monasterio, MJ, Kaminsky, W, Silue, K, Zeeman, AM, Kocken, C, Leroy, D, Blasco, B, Rossignol, E, Rueckle, T, Matthews, D, Burrows, JN, Waterson, D, Palmer, MJ, Rathod, PK, Charman, SA
The emergence of drug resistant malaria parasites continues to hamper efforts to control this lethal disease. Dihydroorotate dehydrogenase has recently been validated as a new target for the treatment of malaria and a selective inhibitor (DSM265) of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::00e11b608b9c68666f8abe95af7f779d
https://doi.org/10.1021/acsinfecdis.6b00144
https://doi.org/10.1021/acsinfecdis.6b00144
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Autor:
Phillips MA, White KL; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, VIC 3052, Australia., Kokkonda S; Departments of Chemistry and Global Health, University of Washington , Seattle, Washington 98195, United States., Deng X, White J; Departments of Chemistry and Global Health, University of Washington , Seattle, Washington 98195, United States., El Mazouni F, Marsh K; AbbVie Inc. , 1 North Waukegan Road, North Chicago, Illinois 60064-6104, United States., Tomchick DR, Manjalanagara K; Syngene International Ltd. , 560 099 Bangalore, India., Rudra KR; Syngene International Ltd. , 560 099 Bangalore, India., Wirjanata G; Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University , P.O. Box 41096, Casuarina, NT 0811, Australia., Noviyanti R; Eijkman Institute for Molecular Biology , Jl. Diponegoro 69, 10430 Jakarta, Indonesia., Price RN; Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University , P.O. Box 41096, Casuarina, NT 0811, Australia.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford , Oxford OX3 7LJ, U.K., Marfurt J; Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University , P.O. Box 41096, Casuarina, NT 0811, Australia., Shackleford DM; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, VIC 3052, Australia., Chiu FC; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, VIC 3052, Australia., Campbell M; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, VIC 3052, Australia., Jimenez-Diaz MB; GlaxoSmithKline , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760, Spain., Bazaga SF; GlaxoSmithKline , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760, Spain., Angulo-Barturen I; GlaxoSmithKline , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760, Spain., Martinez MS; GlaxoSmithKline , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760, Spain., Lafuente-Monasterio M; GlaxoSmithKline , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760, Spain., Kaminsky W; Departments of Chemistry and Global Health, University of Washington , Seattle, Washington 98195, United States., Silue K; Centre Suisse de Recherches Scientifiques en Côte d'Ivoire , Km17, Route de Dabou, Adiopodoumé, BP 1303 Abidjan, Ivory Coast., Zeeman AM; Biomedical Primate Research Centre , 2288 GJ Rijswijk, The Netherlands., Kocken C; Biomedical Primate Research Centre , 2288 GJ Rijswijk, The Netherlands., Leroy D; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Blasco B; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Rossignol E; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Rueckle T; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Matthews D; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Burrows JN; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Waterson D; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Palmer MJ; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Rathod PK; Departments of Chemistry and Global Health, University of Washington , Seattle, Washington 98195, United States., Charman SA; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, VIC 3052, Australia.
Publikováno v:
ACS infectious diseases [ACS Infect Dis] 2016 Dec 09; Vol. 2 (12), pp. 945-957. Date of Electronic Publication: 2016 Oct 04.
Autor:
Kokkonda S; Departments of Chemistry and Global Health, University of Washington , Seattle, Washington 98195, United States., Deng X, White KL; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, VIC 3052, Australia., Coteron JM; GSK , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760 Spain., Marco M; GSK , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760 Spain., de Las Heras L; GSK , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760 Spain., White J; Departments of Chemistry and Global Health, University of Washington , Seattle, Washington 98195, United States., El Mazouni F, Tomchick DR, Manjalanagara K; Syngene International Ltd. , Bangalore 560 099, India., Rudra KR; Syngene International Ltd. , Bangalore 560 099, India., Chen G; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, VIC 3052, Australia., Morizzi J; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, VIC 3052, Australia., Ryan E; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, VIC 3052, Australia., Kaminsky W; Departments of Chemistry and Global Health, University of Washington , Seattle, Washington 98195, United States., Leroy D; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Martínez-Martínez MS; GSK , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760 Spain., Jimenez-Diaz MB; GSK , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760 Spain., Bazaga SF; GSK , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760 Spain., Angulo-Barturen I; GSK , Tres Cantos Medicines Development Campus, Severo Ochoa, Madrid 28760 Spain., Waterson D; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Burrows JN; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Matthews D; Medicines for Malaria Venture , 1215 Geneva, Switzerland., Charman SA; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, VIC 3052, Australia., Phillips MA, Rathod PK; Departments of Chemistry and Global Health, University of Washington , Seattle, Washington 98195, United States.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2016 Jun 09; Vol. 59 (11), pp. 5416-31. Date of Electronic Publication: 2016 May 21.