Výsledky vyhledávání - "Rudolph K. Kullnig"

Synthesis and Evaluation of 6,11-Ethanohexahydrobenzo[b]quinolizidines: A New Class of Noncompetitive N-Methyl-D-aspartate Antagonists

Autor: Chakrapani Subramanyam, William G. Earley, Joseph R. Wetzel, John P. Mallamo, Diane L. DeHaven-Hudkins, Gary M. Pilling, Philip M. Carabateas, Timothy Allen, Rudolph K. Kullnig

Publikováno v: Journal of Medicinal Chemistry. 38:2483-2489

The synthesis and in vitro and in vivo evaluation of 12,13-cycloalkyl-6,11-ethanobenzo[b]-quinolizidines, a new class of noncompetitive N-methyl-D-aspartate (NMDA) antagonists acting at the PCP site on the NMDA receptor complex, is reported. Structur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef324d4752d59b28c371c6e64016ffb3
https://doi.org/10.1021/jm00013a025

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Conformational analysis of 4,5-dihydro-1-phenyl-1H-2,4-benzodiazepines

Autor: Mark A. Sanner, Paul J. Kowalczyk, K. A. Josef, Rudolph K. Kullnig, Thomas E. D'Ambra, Frank M. Michaels, Robert E. Johnson

Publikováno v: The Journal of Organic Chemistry. 58:6417-6420

Detailed conformational analysis of 1-phenyl-1H-4,5-dihydro-2,4-benzodiazepines using X-ray structures, nuclear Overhauser experiments, variable-temperature 1 H NMR, and MacroModel (MULTIC) reveals a rapid equilibrium between axial and equatorial com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f6c1e21aaf45393d5238910e4c1451d
https://doi.org/10.1021/jo00075a042

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Cation-stabilizing auxiliaries in polyene cyclizations. 4. The fluorine atom as a cation-stabilizing auxiliary in biomimetic polyene cyclizations. 1. Background and exploratory experiments

Autor: Fook S. Tham, William S. Johnson, Balan Chenera, Rudolph K. Kullnig

Publikováno v: Journal of the American Chemical Society. 115:493-497

With the aim of testing the fluorine atom as a potential cation-stabilizing (C-S) auxiliary for enhancing polyene cyclizations, new methodology has been developed for the stereoselective synthesis of polyenic cyclization substrates in which the vinyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe63c7cfe3be0b6643ec8d08bfa2040e
https://doi.org/10.1021/ja00055a019

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Cation-stabilizing auxiliaries in polyene cyclizations. 5. The fluorine atom as a cation-stabilizing auxiliary in biomimetic polyene cyclizations. 2. Asymmetric synthesis of a steroid

Autor: Balan Chenera, Rudolph K. Kullnig, Vernon R. Fletcher, William S. Johnson, William R. Bartlett, Fook S. Tham

Publikováno v: Journal of the American Chemical Society. 115:497-504

The use of the fluorine atom an a cation-stabilizing (C-S) auxiliary for enhancing polyene cyclization has been improved in synthetic effectiveness by the demonstration that an acetal 5 can be converted to a racemic fluorocycle, bearing the natural b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4df628f673073539676361f3b97519a
https://doi.org/10.1021/ja00055a020

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Cation-stabilizing auxiliaries in polyene cyclizations. 6. The fluorine atom as a cation-stabilizing auxiliary in biomimetic polyene cyclizations. 3. Use to effect regiospecific control

Autor: William R. Bartlett, Rudolph K. Kullnig, Robert A. Buchanan, Fook S. Tham, William S. Johnson

Publikováno v: Journal of the American Chemical Society. 115:504-515

The fluorine atom substituted at the pro-C-13 position (steroid numbering) has been shown to be an effective cation-stabilizing (C-S) auxiliary in the acid-catalyzed cyclization of polyene substrates. The preparation of these polyenes employed the kn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc1c0c28a5b11f6da011c603ab924061
https://doi.org/10.1021/ja00055a021

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ChemInform Abstract: Synthesis of Aza Macrocycles from Polycyclic 5-Aminoisoxazoline Precursors

Autor: Fook S. Tham, Mark P. Wentland, Rudolph K. Kullnig

Publikováno v: ChemInform. 22

A series of novel isoxazolo analogues 11 of the dibenzazonine alkaloid protostephanine (1) has been prepared. A new regiospecific and potentially general aza macrocyclic ring forming process was developed where the first step was the 1,3-dipolar cycl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74b94cba914cb4c3fcbf4b8e8fd6c04c
https://doi.org/10.1002/chin.199152233

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ChemInform Abstract: 5-Lipoxygenase Inhibitors: The Synthesis and Structure-Activity Relationships of a Series of 1-Phenyl-3-pyrazolidinones

Autor: Edward P. Jaeger, Edward Ferguson, Robert J. Gordon, Sally J. Gangell, Rudolph K. Kullnig, Dennis J. Hlasta, Martha R. Heimann, Francis B. Casey

Publikováno v: ChemInform. 22

A series of analogues of the 5-lipoxygenase inhibitor 1-phenyl-3-pyrazolidinone (phenidone, 1a) has been prepared via two complementary new synthetic methods. The reaction of various electgrophiles with the dianion of 1a or with an N-silylpyrazolidin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e319d28cdbdb2d40ec5a2b9e41e8d927
https://doi.org/10.1002/chin.199145155

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