Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Rudolph J. Castellani"'
Autor:
Preethy S. Sridharan, Yeojung Koh, Emiko Miller, Di Hu, Suwarna Chakraborty, Sunil Jamuna Tripathi, Teresa R. Kee, Kalyani Chaubey, Edwin Vázquez-Rosa, Sarah Barker, Hui Liu, Rose A. León-Alvarado, Kathryn Franke, Coral J. Cintrón-Pérez, Matasha Dhar, Min-Kyoo Shin, Margaret E. Flanagan, Rudolph J. Castellani, Tamar Gefen, Marina Bykova, Lijun Dou, Feixiong Cheng, Brigid M. Wilson, Hisashi Fujioka, David E. Kang, Jung-A.A. Woo, Bindu D. Paul, Xin Qi, Andrew A. Pieper
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101715- (2024)
Summary: Progression of acute traumatic brain injury (TBI) into chronic neurodegeneration is a major health problem with no protective treatments. Here, we report that acutely elevated mitochondrial fission after TBI in mice triggers chronic neurodeg
Externí odkaz:
https://doaj.org/article/78517b6c384645a8be41713376606e5d
Publikováno v:
Neurotrauma Reports, Vol 5, Iss 1, Pp 337-347 (2024)
There are no validated diagnostic criteria for traumatic encephalopathy syndrome (TES). During the early and middle 20th century, TES was described as a clinical condition that was experienced by some high-exposure boxers?and it was believed to refle
Externí odkaz:
https://doaj.org/article/8571c74310954803be37a8314a20dc6e
Autor:
Poul F. Høilund-Carlsen, Abass Alavi, Rudolph J. Castellani, Rachael L. Neve, George Perry, Mona-Elisabeth Revheim, Jorge R. Barrio
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 7, p 3892 (2024)
The amyloid cascade hypothesis for Alzheimer’s disease is still alive, although heavily challenged. Effective anti-amyloid immunotherapy would confirm the hypothesis’ claim that the protein amyloid-beta is the cause of the disease. Two antibodies
Externí odkaz:
https://doaj.org/article/aea8e36723d84cb4930ac3151d18907f
Autor:
Grant L. Iverson, Alicia Kissinger-Knox, Nathan A. Huebschmann, Rudolph J. Castellani, Andrew J. Gardner
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
IntroductionSome ultra-high exposure boxers from the 20th century suffered from neurological problems characterized by slurred speech, personality changes (e.g., childishness or aggressiveness), and frank gait and coordination problems, with some not
Externí odkaz:
https://doaj.org/article/65133464990f45e399a458dd17cc29ff
Autor:
Grant L. Iverson, Pouya Jamshidi, Amanda O. Fisher-Hubbard, Amy Deep-Soboslay, Thomas M. Hyde, Joel E. Kleinman, Joyce L. deJong, Claire E. Shepherd, Lili-Naz Hazrati, Rudolph J. Castellani
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
IntroductionWe examined postmortem brain tissue from men, over the age of 50, for chronic traumatic encephalopathy neuropathologic change (CTE-NC). We hypothesized that (i) a small percentage would have CTE-NC, (ii) those who played American football
Externí odkaz:
https://doaj.org/article/857b1001775f471c9183059d1508598a
Autor:
Poul F. Høilund-Carlsen, Mona-Elisabeth Revheim, Tommaso Costa, Kasper P. Kepp, Rudolph J. Castellani, George Perry, Abass Alavi, Jorge R. Barrio
Publikováno v:
Diagnostics, Vol 13, Iss 13, p 2254 (2023)
In June 2021, the US Federal Drug and Food Administration (FDA) granted accelerated approval for the antibody aducanumab and, in January 2023, also for the antibody lecanemab, based on a perceived drug-induced removal of cerebral amyloid-beta as asse
Externí odkaz:
https://doaj.org/article/56dd93d1fd53436e9f13656384986f97
Autor:
Peter Stanwell, Grant L. Iverson, Ryan Van Patten, Rudolph J. Castellani, Paul McCrory, Andrew J. Gardner
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
ObjectiveA cavum septum pellucidum (CSP) has been reported as a visible brain anomaly in normal individuals as well in some former combat and collision sport athletes. The appearance of CSP with fenestrations and ventricular enlargement are considere
Externí odkaz:
https://doaj.org/article/4e4dcda7f1624820beed76ecc6165fb1
Autor:
Grant L. Iverson, Amy Deep-Soboslay, Thomas M. Hyde, Joel E. Kleinman, Brittany Erskine, Amanda Fisher-Hubbard, Joyce L. deJong, Rudolph J. Castellani
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Introduction: It is reasonable to estimate that tens of millions of men in the United States played high school football. There is societal concern that participation in football confers risk for later-in-life mental health problems. The purpose of t
Externí odkaz:
https://doaj.org/article/f6f3e3c64cfe4151a3d92cf970bac71d
Autor:
Rudolph J. Castellani, Elisheva D. Shanes, Matthew McCord, Nicholas J. Reish, Margaret E. Flanagan, M-Marsel Mesulam, Pouya Jamshidi
Publikováno v:
Journal of Alzheimer's Disease. 93:803-813
Host responses to anti-amyloid-β (Aβ) antibody therapy are evident in neuroimaging changes and clinical symptoms in a subset of clinical trial subjects receiving such therapy. The pathological basis for the imaging changes and clinical symptoms is
Autor:
Rachel A, Multz, Callen, Spencer, Arleen, Matos, Kaouther, Ajroud, Carlos, Zamudio, Eileen, Bigio, Qinwen, Mao, Rose A, Medeiros, Jared T, Ahrendsen, Rudolph J, Castellani, Margaret E, Flanagan
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 82:103-109
Concerns about the costs associated with autopsy assessment of Alzheimer disease and related dementias according to 2012 NIA-AA Guidelines have been expressed since the publication of those guidelines. For this reason, we designed and validated a Con