Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Rudolph J Castellani"'
Publikováno v:
Journal of Forensic Science and Medicine, Vol 8, Iss 2, Pp 41-45 (2022)
Background: The pathophysiology of lethal head trauma in infants and young children involves repetitive rotational forces of sufficient magnitude to produce subdural hemorrhage and brain swelling, which leads to considerable morbidity and mortality.
Externí odkaz:
https://doaj.org/article/e62262413d8440998648d3d8d3b7e5da
Autor:
Tanvi Nadkarni, Kimberly Hamilton, Faraze Niazi, Melanie Ward, Uchenna Okakpu, Rudolph J Castellani, Ion Prisneac, Ugur Sener
Publikováno v:
CNS Oncology, Vol 10, Iss 3 (2021)
Glioblastoma multiforme is the most common malignant primary brain tumor in adults. Histone H3 mutations have been identified in pediatric and adult gliomas, with H3K27M mutations typically associated with a posterior fossa midline tumor location and
Externí odkaz:
https://doaj.org/article/fc23e69f50d743a69450419c38a6dea0
Autor:
Nina P Connolly, Jesse A Stokum, Craig S Schneider, Tatsuya Ozawa, Su Xu, Rebeca Galisteo, Rudolph J Castellani, Anthony J Kim, J Marc Simard, Jeffrey A Winkles, Eric C Holland, Graeme F Woodworth
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174557 (2017)
Previously rodent preclinical research in gliomas frequently involved implantation of cell lines such as C6 and 9L into the rat brain. More recently, mouse models have taken over, the genetic manipulability of the mouse allowing the creation of genet
Externí odkaz:
https://doaj.org/article/ce4d67caefef4259afcb22825fc8a412
Autor:
Preethy S. Sridharan, Yeojung Koh, Emiko Miller, Di Hu, Suwarna Chakraborty, Sunil Jamuna Tripathi, Teresa R. Kee, Kalyani Chaubey, Edwin Vázquez-Rosa, Sarah Barker, Hui Liu, Rose A. León-Alvarado, Kathryn Franke, Coral J. Cintrón-Pérez, Matasha Dhar, Min-Kyoo Shin, Margaret E. Flanagan, Rudolph J. Castellani, Tamar Gefen, Marina Bykova, Lijun Dou, Feixiong Cheng, Brigid M. Wilson, Hisashi Fujioka, David E. Kang, Jung-A.A. Woo, Bindu D. Paul, Xin Qi, Andrew A. Pieper
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101715- (2024)
Summary: Progression of acute traumatic brain injury (TBI) into chronic neurodegeneration is a major health problem with no protective treatments. Here, we report that acutely elevated mitochondrial fission after TBI in mice triggers chronic neurodeg
Externí odkaz:
https://doaj.org/article/78517b6c384645a8be41713376606e5d
Publikováno v:
Neurotrauma Reports, Vol 5, Iss 1, Pp 337-347 (2024)
There are no validated diagnostic criteria for traumatic encephalopathy syndrome (TES). During the early and middle 20th century, TES was described as a clinical condition that was experienced by some high-exposure boxers?and it was believed to refle
Externí odkaz:
https://doaj.org/article/8571c74310954803be37a8314a20dc6e
Autor:
Grant L. Iverson, Alicia Kissinger-Knox, Nathan A. Huebschmann, Rudolph J. Castellani, Andrew J. Gardner
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
IntroductionSome ultra-high exposure boxers from the 20th century suffered from neurological problems characterized by slurred speech, personality changes (e.g., childishness or aggressiveness), and frank gait and coordination problems, with some not
Externí odkaz:
https://doaj.org/article/65133464990f45e399a458dd17cc29ff
Autor:
Grant L. Iverson, Pouya Jamshidi, Amanda O. Fisher-Hubbard, Amy Deep-Soboslay, Thomas M. Hyde, Joel E. Kleinman, Joyce L. deJong, Claire E. Shepherd, Lili-Naz Hazrati, Rudolph J. Castellani
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
IntroductionWe examined postmortem brain tissue from men, over the age of 50, for chronic traumatic encephalopathy neuropathologic change (CTE-NC). We hypothesized that (i) a small percentage would have CTE-NC, (ii) those who played American football
Externí odkaz:
https://doaj.org/article/857b1001775f471c9183059d1508598a
Autor:
Poul F. Høilund-Carlsen, Mona-Elisabeth Revheim, Tommaso Costa, Kasper P. Kepp, Rudolph J. Castellani, George Perry, Abass Alavi, Jorge R. Barrio
Publikováno v:
Diagnostics, Vol 13, Iss 13, p 2254 (2023)
In June 2021, the US Federal Drug and Food Administration (FDA) granted accelerated approval for the antibody aducanumab and, in January 2023, also for the antibody lecanemab, based on a perceived drug-induced removal of cerebral amyloid-beta as asse
Externí odkaz:
https://doaj.org/article/56dd93d1fd53436e9f13656384986f97
Autor:
Rudolph J. Castellani, Elisheva D. Shanes, Matthew McCord, Nicholas J. Reish, Margaret E. Flanagan, M-Marsel Mesulam, Pouya Jamshidi
Publikováno v:
Journal of Alzheimer's Disease. 93:803-813
Host responses to anti-amyloid-β (Aβ) antibody therapy are evident in neuroimaging changes and clinical symptoms in a subset of clinical trial subjects receiving such therapy. The pathological basis for the imaging changes and clinical symptoms is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67e44e9211932357fb18c5d7625ae737
https://doi.org/10.3233/jad-221305
https://doi.org/10.3233/jad-221305
Autor:
Rachel A, Multz, Callen, Spencer, Arleen, Matos, Kaouther, Ajroud, Carlos, Zamudio, Eileen, Bigio, Qinwen, Mao, Rose A, Medeiros, Jared T, Ahrendsen, Rudolph J, Castellani, Margaret E, Flanagan
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 82:103-109
Concerns about the costs associated with autopsy assessment of Alzheimer disease and related dementias according to 2012 NIA-AA Guidelines have been expressed since the publication of those guidelines. For this reason, we designed and validated a Con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48399b9abbf64a409f1f11902688fe5d
https://doi.org/10.1093/jnen/nlac114
https://doi.org/10.1093/jnen/nlac114