Zobrazeno 1 - 10
of 3 719
pro vyhledávání: '"Rudolph E"'
Autor:
Florian Perrin, Lauren C. Anderson, Shane P. C. Mitchell, Priyanka Sinha, Yuliia Turchyna, Masato Maesako, Mei C. Q. Houser, Can Zhang, Steven L. Wagner, Rudolph E. Tanzi, Oksana Berezovska
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-17 (2024)
Abstract The recently discovered interaction between presenilin 1 (PS1), a subunit of γ-secretase involved in amyloid-β (Aβ) peptide production, and GLT-1, the major brain glutamate transporter (EAAT2 in the human), may link two pathological aspec
Externí odkaz:
https://doaj.org/article/ca2040f77bea44028933d446ce3fab62
Publikováno v:
STAR Protocols, Vol 5, Iss 4, Pp 103364- (2024)
Summary: Mast cells, which constitute tissue-resident immune cells, are distributed in the dural meninges. Here, we provide procedural guidelines for investigating mouse dural mast cells using two techniques. First, we outline the procedures for dura
Externí odkaz:
https://doaj.org/article/cc2aa25ff2184cb1aa41578c6d52fddc
Autor:
Sanjula D. Singh, Cyprien A. Rivier, Keren Papier, Zeina Chemali, Leidys Gutierrez-Martinez, Livia Parodi, Ernst Mayerhofer, Jasper Senff, Santiago Clocchiatti-Tuozzo, Courtney Nunley, Amy Newhouse, An Ouyang, M. Brandon Westover, Rudolph E. Tanzi, Ronald M. Lazar, Aleksandra Pikula, Sarah Ibrahim, H. Bart Brouwers, Virginia J. Howard, George Howard, Nirupama Yechoor, Thomas Littlejohns, Kevin N. Sheth, Jonathan Rosand, Gregory Fricchione, Christopher D. Anderson, Guido J. Falcone
Publikováno v:
Frontiers in Psychiatry, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/97936073fee1465093218f6396189b30
Autor:
Sanjula D. Singh, Tin Oreskovic, Sinclair Carr, Keren Papier, Megan Conroy, Jasper R. Senff, Zeina Chemali, Leidys Gutierrez-Martinez, Livia Parodi, Ernst Mayerhofer, Sandro Marini, Courtney Nunley, Amy Newhouse, An Ouyang, H. Bart Brouwers, Brandon Westover, Cyprien Rivier, Guido Falcone, Virginia Howard, George Howard, Aleksandra Pikula, Sarah Ibrahim, Kevin N. Sheth, Nirupama Yechoor, Ronald M. Lazar, Christopher D. Anderson, Rudolph E. Tanzi, Gregory Fricchione, Thomas Littlejohns, Jonathan Rosand
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/4e6a0dc587a5403e9f270ffa8a522c10
Autor:
Dean Ornish, Catherine Madison, Miia Kivipelto, Colleen Kemp, Charles E. McCulloch, Douglas Galasko, Jon Artz, Dorene Rentz, Jue Lin, Kim Norman, Anne Ornish, Sarah Tranter, Nancy DeLamarter, Noel Wingers, Carra Richling, Rima Kaddurah-Daouk, Rob Knight, Daniel McDonald, Lucas Patel, Eric Verdin, Rudolph E. Tanzi, Steven E. Arnold
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-17 (2024)
Abstract Background Evidence links lifestyle factors with Alzheimer’s disease (AD). We report the first randomized, controlled clinical trial to determine if intensive lifestyle changes may beneficially affect the progression of mild cognitive impa
Externí odkaz:
https://doaj.org/article/88f3200bfb0542db8b347084c5b976dd
Autor:
Megan E. Bosch, Hemraj B. Dodiya, Julia Michalkiewicz, Choonghee Lee, Shabana M. Shaik, Ian Q. Weigle, Can Zhang, Jack Osborn, Aishwarya Nambiar, Priyam Patel, Samira Parhizkar, Xiaoqiong Zhang, Marie L. Laury, Prasenjit Mondal, Ashley Gomm, Matthew John Schipma, Dania Mallah, Oleg Butovsky, Eugene B. Chang, Rudolph E. Tanzi, Jack A. Gilbert, David M. Holtzman, Sangram S. Sisodia
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/14d8b48203894334ae62b75a08c5835b
Autor:
Ping Bai, Yu Lan, Yan Liu, Prasenjit Mondal, Ashley Gomm, Yulong Xu, Yanli Wang, Yongle Wang, Leyi Kang, Lili Pan, Frederick A. Bagdasarian, Madelyn Hallisey, Fleur Lobo, Breanna Varela, Se Hoon Choi, Stephen N. Gomperts, Hsiao‐Ying Wey, Shiqian Shen, Rudolph E. Tanzi, Changning Wang, Can Zhang
Publikováno v:
Advanced Science, Vol 11, Iss 32, Pp n/a-n/a (2024)
Abstract Targeting receptor‐interacting protein kinase 1 (RIPK1) has emerged as a promising therapeutic stratagem for neurodegenerative disorders, particularly Alzheimer's disease (AD). A positron emission tomography (PET) probe enabling brain RIPK
Externí odkaz:
https://doaj.org/article/6a95c45a9c77468596a655055eef9238
Autor:
Steven E. Arnold, Suzanne Hendrix, Jessie Nicodemus‐Johnson, Newman Knowlton, Victoria J. Williams, Jeffrey M. Burns, Monica Crane, Alison J. McManus, Sanjeev N. Vaishnavi, Zoe Arvanitakis, Judith Neugroschl, Karen Bell, Bianca A. Trombetta, Becky C. Carlyle, Pia Kivisäkk, Hiroko H. Dodge, Rudolph E. Tanzi, Patrick D. Yeramian, Kent Leslie
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 10, Iss 3, Pp n/a-n/a (2024)
Abstract INTRODUCTION Sodium phenylbutyrate and taurursodiol (PB and TURSO) is hypothesized to mitigate endoplasmic reticulum stress and mitochondrial dysfunction, two of many mechanisms implicated in Alzheimer's disease (AD) pathophysiology. METHODS
Externí odkaz:
https://doaj.org/article/094dc11770e44f12a0e5cddf65670bfc
Autor:
Sanjula D. Singh, Cyprien A. Rivier, Keren Papier, Zeina Chemali, Leidys Gutierrez-Martinez, Livia Parodi, Ernst Mayerhofer, Jasper Senff, Santiago Clocchiatti-Tuozzo, Courtney Nunley, Amy Newhouse, An Ouyang, M. Brandon Westover, Rudolph E. Tanzi, Ronald M. Lazar, Aleksandra Pikula, Sarah Ibrahim, H. Bart Brouwers, Virginia J. Howard, George Howard, Nirupama Yechoor, Thomas Littlejohns, Kevin N. Sheth, Jonathan Rosand, Gregory Fricchione, Christopher D. Anderson, Guido J. Falcone
Publikováno v:
Frontiers in Psychiatry, Vol 15 (2024)
IntroductionThe 21-point Brain Care Score (BCS) is a novel tool designed to motivate individuals and care providers to take action to reduce the risk of stroke and dementia by encouraging lifestyle changes. Given that late-life depression is increasi
Externí odkaz:
https://doaj.org/article/50fe1aa648a74b0a92d860147aa06eab
Autor:
Megan E. Bosch, Hemraj B. Dodiya, Julia Michalkiewicz, Choonghee Lee, Shabana M. Shaik, Ian Q. Weigle, Can Zhang, Jack Osborn, Aishwarya Nambiar, Priyam Patel, Samira Parhizkar, Xiaoqiong Zhang, Marie L. Laury, Prasenjit Mondal, Ashley Gomm, Matthew John Schipma, Dania Mallah, Oleg Butovsky, Eugene B. Chang, Rudolph E. Tanzi, Jack A. Gilbert, David M. Holtzman, Sangram S. Sisodia
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-26 (2024)
Abstract It has recently become well-established that there is a connection between Alzheimer’s disease pathology and gut microbiome dysbiosis. We have previously demonstrated that antibiotic-mediated gut microbiota perturbations lead to attenuatio
Externí odkaz:
https://doaj.org/article/5d6226d85e844091868e4f867d83ad18