Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Rudolf Volkmer"'
Autor:
Franziska Siegel, Hannes Schmidt, Manisha Juneja, Janice Smith, Pia Herrmann, Dennis Kobelt, Kamal Sharma, Iduna Fichtner, Wolfgang Walther, Gunnar Dittmar, Rudolf Volkmer, Fritz G. Rathjen, Peter M. Schlag, Ulrike Stein
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundIdentification of cancer metastasis-relevant molecular networks is desired to provide the basis for understanding and developing intervention strategies. Here we address the role of GIPC1 in the process of MACC1-driven metastasis. MACC1 is
Externí odkaz:
https://doaj.org/article/f7057db6ffbe4927a16349f2de8304f9
Autor:
Magdalena Czuban, Sangeetha Srinivasan, Nathan A. Yee, Edgar Agustin, Anna Koliszak, Ethan Miller, Irfan Khan, Ilenis Quinones, Hasina Noory, Christopher Motola, Rudolf Volkmer, Mariagrazia Di Luca, Andrej Trampuz, Maksim Royzen, Jose M. Mejia Oneto
Publikováno v:
ACS Central Science, Vol 4, Iss 12, Pp 1624-1632 (2018)
Externí odkaz:
https://doaj.org/article/59e63920b4f34df0858488056380c27d
Autor:
Jennifer Pfeil, Mario Simonetti, Uta Lauer, Rudolf Volkmer, Bianca von Thülen, Pawel Durek, Ralf Krähmer, Frank Leenders, Alf Hamann, Ute Hoffmann
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Current treatments for autoimmune disorders rely on non-specific immunomodulatory and global immunosuppressive drugs, which show a variable degree of efficiency and are often accompanied by side effects. In contrast, strategies aiming at inducing ant
Externí odkaz:
https://doaj.org/article/d9cbc032df4a4db2bc473021cefb52f8
Autor:
Rebecca L. Eccles, Maciej T. Czajkowski, Carolin Barth, Paul Markus Müller, Erik McShane, Stephan Grunwald, Patrick Beaudette, Nora Mecklenburg, Rudolf Volkmer, Kerstin Zühlke, Gunnar Dittmar, Matthias Selbach, Annette Hammes, Oliver Daumke, Enno Klussmann, Sylvie Urbé, Oliver Rocks
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Protein kinase A (PKA) is a key mediator of cyclic AMP signalling. Here, Eccles et al. show that ARHGAP36 antagonizes PKA by acting as a kinase inhibitor and targeting the catalytic subunit for endolysosomal degradation, thus reducing sensitivity of
Externí odkaz:
https://doaj.org/article/4b603724ee39452aa970f9812ba07050
Autor:
Vladimir J. Arellano, Paula Martinell García, Jonathan G. Rodríguez Plaza, Maria T. Lara Ortiz, Gabriele Schreiber, Rudolf Volkmer, Edda Klipp, Gabriel Del Rio
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Although most antibiotics act on cells that are actively dividing and non-dividing cells such as in microbe sporulation or cancer stem cells represent a new paradigm for the control of disease. In addition to their relevance to health, such antibioti
Externí odkaz:
https://doaj.org/article/654d5472660741f487fdee7b80b32d93
Autor:
Lisa Maria Henning, Sumati Bhatia, Miriam Bertazzon, Michaela Marczynke, Oliver Seitz, Rudolf Volkmer, Rainer Haag, Christian Freund
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 11, Iss 1, Pp 701-706 (2015)
The coupling of peptides to polyglycerol carriers represents an important route towards the multivalent display of protein ligands. In particular, the inhibition of low affinity intracellular protein–protein interactions can be addressed by this de
Externí odkaz:
https://doaj.org/article/11912349a34949da85b29aaead8d0e3b
Autor:
Daniel Lauster, Damian Pawolski, Julian Storm, Kai Ludwig, Rudolf Volkmer, Henry Memczak, Andreas Herrmann, Sumati Bhatia
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 11, Iss 1, Pp 589-595 (2015)
For antiviral drug design, especially in the field of influenza virus research, potent multivalent inhibitors raise high expectations for combating epidemics and pandemics. Among a large variety of covalent and non-covalent scaffold systems for a mul
Externí odkaz:
https://doaj.org/article/033c3cc0daee416f990d1cc606d5cb7d
Publikováno v:
eLife, Vol 6 (2017)
At synapses throughout the mammalian brain, AMPA receptors form complexes with auxiliary proteins, including TARPs. However, how TARPs modulate AMPA receptor gating remains poorly understood. We built structural models of TARP-AMPA receptor complexes
Externí odkaz:
https://doaj.org/article/007b1390811a488a81b65ece18286d1b
Autor:
Henry Memczak, Daniel Lauster, Parimal Kar, Santiago Di Lella, Rudolf Volkmer, Volker Knecht, Andreas Herrmann, Eva Ehrentreich-Förster, Frank F Bier, Walter F M Stöcklein
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159074 (2016)
Antibodies against spike proteins of influenza are used as a tool for characterization of viruses and therapeutic approaches. However, development, production and quality control of antibodies is expensive and time consuming. To circumvent these diff
Externí odkaz:
https://doaj.org/article/1d7b76e8692c4d86bb9cfe00adb94493
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 8, Iss 1, Pp 640-649 (2012)
We screened a randomized library and identified natural peptides that bound selectively to a chimeric peptide containing α-, β- and γ-amino acids. The SPOT arrays provide a means for the systematic study of the possible interaction space accessibl
Externí odkaz:
https://doaj.org/article/64ae90143c5e440a88565ba10dd16e0f