Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Rudolf Pisa"'
Publikováno v:
Nature chemical biology
Spastin is a microtubule-severing AAA (ATPases associated with diverse cellular activities) protein needed for cell division and intracellular vesicle transport. Currently, we lack chemical inhibitors to probe spastin function in such dynamic cellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbd6a1820210767bbf430c9a80e833a1
https://doi.org/10.1038/s41589-019-0225-6
https://doi.org/10.1038/s41589-019-0225-6
Autor:
Rudolf Pisa, Tom A. Rapoport
Publikováno v:
Journal of Biological Chemistry. 298:102373
Misfolded proteins in the lumen of the endoplasmic reticulum (ER) are retrotranslocated into the cytosol and degraded by the ubiquitin-proteasome system, a pathway termed luminal ER-associated protein degradation. Retrotranslocation is mediated by a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da93a99204af3964e7d129b0c9a6f433
https://doi.org/10.1016/j.jbc.2022.102373
https://doi.org/10.1016/j.jbc.2022.102373
Publikováno v:
Nat Struct Mol Biol
The structural conservation across the AAA (ATPases associated with diverse cellular activities) protein family makes designing selective chemical inhibitors challenging. Here, we identify a triazolopyridine-based fragment that binds the AAA domain o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6376ca47128bcfe9ae07f4a5b52b29d
https://pubmed.ncbi.nlm.nih.gov/33782614
https://pubmed.ncbi.nlm.nih.gov/33782614
Autor:
Tarun M. Kapoor, Rudolf Pisa
Publikováno v:
Nat Chem Biol
Emergence of resistance is a major factor limiting the efficacy of molecularly targeted anticancer drugs. Understanding the specific mutations, or other genetic or cellular changes, that confer drug resistance can help in the development of therapeut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a95cb4ee8b062a7aa2dd95399c849d09
https://pubmed.ncbi.nlm.nih.gov/32694636
https://pubmed.ncbi.nlm.nih.gov/32694636
Publikováno v:
Cell Chem Biol
Summary Drug-like inhibitors are often designed by mimicking cofactor or substrate interactions with enzymes. However, as active sites are comprised of conserved residues, it is difficult to identify the critical interactions needed to design selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad5fa450865ad8a2a6d3e0eafa7668d6
https://pubmed.ncbi.nlm.nih.gov/31257183
https://pubmed.ncbi.nlm.nih.gov/31257183
The bump-hole approach is a powerful chemical biology strategy to specifically probe the functions of closely related proteins. However, for many protein families, such as the ATPases associated with diverse cellular activities (AAA), we lack structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78cec0fb780905f70bbacdfff913d43b
https://europepmc.org/articles/PMC6637947/
https://europepmc.org/articles/PMC6637947/
Publikováno v:
Cell Chem Biol
Aberrant chromosome numbers in cancer cells may impose distinct constraints on the emergence of drug resistance-a major factor limiting the long-term efficacy of molecularly targeted therapeutics. However, for most anticancer drugs we lack analyses o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::096338421f0e5bf2cd6b61c27776800d
https://doi.org/10.1016/j.chembiol.2020.05.003
https://doi.org/10.1016/j.chembiol.2020.05.003
Publikováno v:
SSRN Electronic Journal.
Drug-like inhibitors are often designed by mimicking cofactor or substrate interactions with enzymes. However, as active sites are comprised of conserved residues, it is difficult to identify the critical interactions needed to design selective inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::711bf372a33e6a73dad0b96d6a7a8cab
https://doi.org/10.2139/ssrn.3372968
https://doi.org/10.2139/ssrn.3372968
Autor:
Sebastian Greiss, Thomas S. Elliott, Jason W. Chin, Kathryn S. Lilley, Russell J. Ernst, Lloyd S. Davis, Amit Sachdeva, Ambra Bianco, Kathrin Lang, Simon J. Elsässer, Rudolf Pisa, Fiona M. Townsley
Identifying the proteins synthesized at specific times in cells of interest in an animal will facilitate the study of cellular functions and dynamic processes. Here we introduce stochastic orthogonal recoding of translation with chemoselective modifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f4c8d22c25c65bdc8f5edd80e71400b
https://europepmc.org/articles/PMC4107302/
https://europepmc.org/articles/PMC4107302/