Zobrazeno 1 - 10
of 294
pro vyhledávání: '"Rudolf P Wüthrich"'
Autor:
Marco Bonani, Alexandre Balaphas, Giulia Bedino, Léo Bühler, Philipp Dutkowski, Kathrin Fausch, Silvia Gluderer, Nicole Graf, Patricia Hirt-Minkowski, Beat Müllhaupt, Carlo Schönholzer, Martin MP Schulz, Reto Venzin, Rudolf P Wüthrich
Publikováno v:
Swiss Medical Weekly, Vol 151, Iss 0708 (2021)
AIMS OF THE STUDY Non-adherence to immunosuppressive therapy in patients following solid organ transplantation is associated with an increased risk of transplant rejection and graft loss. A high pill burden can adversely affect patients’ implement
Externí odkaz:
https://doaj.org/article/8d6891a5a101466c8688e866653dd379
Autor:
Meliana Riwanto, Sarika Kapoor, Daniel Rodriguez, Ilka Edenhofer, Stephan Segerer, Rudolf P Wüthrich
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146654 (2016)
Dysregulated signaling cascades alter energy metabolism and promote cell proliferation and cyst expansion in polycystic kidney disease (PKD). Here we tested whether metabolic reprogramming towards aerobic glycolysis ("Warburg effect") plays a pathoge
Externí odkaz:
https://doaj.org/article/0435e1e8887e4a03a34546f23164bc51
Autor:
Sarika Kapoor, Daniel Rodriguez, Meliana Riwanto, Ilka Edenhofer, Stephan Segerer, Katharyn Mitchell, Rudolf P Wüthrich
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0125603 (2015)
The sodium-glucose-cotransporter-2 (SGLT2) inhibitor dapagliflozin (DAPA) induces glucosuria and osmotic diuresis via inhibition of renal glucose reabsorption. Since increased diuresis retards the progression of polycystic kidney disease (PKD), we in
Externí odkaz:
https://doaj.org/article/3dc4277db91e4d6f9a74f5d765e7dc4b
Autor:
Dongping Chen, Yiyi Ma, Xueqi Wang, Shengqiang Yu, Lin Li, Bing Dai, Zhiguo Mao, Lijun Sun, Chenggang Xu, Shu Rong, Mengjun Tang, Hongbo Zhao, Hongchao Liu, Andreas L Serra, Nicole Graf, Shiyuan Liu, Rudolf P Wüthrich, Changlin Mei
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92232 (2014)
Autosomal dominant polycystic kidney disease (ADPKD) is a relentlessly progressing form of chronic kidney disease for which there is no cure. The aim of this study was to characterize Chinese patients with ADPKD and to identify the factors which pred
Externí odkaz:
https://doaj.org/article/2be392cf1a2742f1ba1eb92a25eb88f9
Autor:
Andreas D Kistler, Andreas L Serra, Justyna Siwy, Diane Poster, Fabienne Krauer, Vicente E Torres, Michal Mrug, Jared J Grantham, Kyongtae T Bae, James E Bost, William Mullen, Rudolf P Wüthrich, Harald Mischak, Arlene B Chapman
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53016 (2013)
Treatment options for autosomal dominant polycystic kidney disease (ADPKD) will likely become available in the near future, hence reliable diagnostic and prognostic biomarkers for the disease are strongly needed. Here, we aimed to define urinary prot
Externí odkaz:
https://doaj.org/article/7f1ebb423b8d46c0a90c2566f7c90e43
Autor:
Matthias Braun, James Young, Cäcilia S Reiner, Diane Poster, Fabienne Krauer, Andreas D Kistler, Paulus Kristanto, Xueqi Wang, Yang Liu, Johannes Loffing, Gustav Andreisek, Arnold von Eckardstein, Oliver Senn, Rudolf P Wüthrich, Andreas L Serra
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e45868 (2012)
Sirolimus has been approved for clinical use in non proliferative and proliferative disorders. It inhibits the mammalian target of rapamycin (mTOR) signaling pathway which is also known to regulate ovarian morphology and function. Preliminary observa
Externí odkaz:
https://doaj.org/article/d17e7527a33940d88e7af13e3155ed3b
Autor:
Niko Braun, M Dominik Alscher, Peter Fritz, Joerg Latus, Ilka Edenhofer, Fabian Reimold, Seth L Alper, Martin Kimmel, Dagmar Biegger, Maja Lindenmeyer, Clemens D Cohen, Rudolf P Wüthrich, Stephan Segerer
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e53382 (2012)
Encapsulating peritoneal sclerosis (EPS) is a life threatening complication of peritoneal dialysis (PD). Podoplanin is a glycoprotein expressed by mesothelial cells, lymphatic endothelial cells, and myofibroblasts in peritoneal biopsies from patients
Externí odkaz:
https://doaj.org/article/3780375f658d4381bb982752e7694866
Autor:
Andreas D Kistler, Justyna Siwy, Frank Breunig, Praveen Jeevaratnam, Alexander Scherl, William Mullen, David G Warnock, Christoph Wanner, Derralynn A Hughes, Harald Mischak, Rudolf P Wüthrich, Andreas L Serra
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20534 (2011)
Female patients affected by Fabry disease, an X-linked lysosomal storage disorder, exhibit a wide spectrum of symptoms, which renders diagnosis, and treatment decisions challenging. No diagnostic test, other than sequencing of the alpha-galactosidase
Externí odkaz:
https://doaj.org/article/4596ac9f92c4499ea0df20e143c39816
Autor:
Gino Miele, Harald Seeger, Denis Marino, Ralf Eberhard, Mathias Heikenwalder, Katharina Stoeck, Max Basagni, Richard Knight, Alison Green, Francesca Chianini, Rudolf P Wüthrich, Christoph Hock, Inga Zerr, Adriano Aguzzi
Publikováno v:
PLoS ONE, Vol 3, Iss 12, p e3870 (2008)
The occurrence of blood-borne prion transmission incidents calls for identification of potential prion carriers. However, current methods for intravital diagnosis of prion disease rely on invasive tissue biopsies and are unsuitable for large-scale sc
Externí odkaz:
https://doaj.org/article/54afcf6458dd4511857b36893341d36a
Autor:
Andreas D. Kistler, Rudolf P. Wüthrich, Malte Kölling, Felix Beuschlein, Albina Nowak, Johan M. Lorenzen, Stellor Nlandu-Khodo, George Haddad
Publikováno v:
Journal of Medical Genetics. 59:279-286
BackgroundFabry disease is a rare X-linked lysosomal storage disease caused by mutations in the galactosidase α gene. Deficient activity of α-galactosidase A leads to glycosphingolipid accumulations in multiple organs. Circular RNAs represent stron