Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Rudolf Knuppen"'
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 54:131-139
We recently established and characterized two rat endometrial adenocarcinoma cell lines which we called RUCA-I and RUCA-II. Despite high estrogen receptor levels neither cell line responded to estradiol in conventional cell culture conditions on plas
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 50:261-266
Synthetic analogs of estrone sulfate which carry differently substituted sulfonyl groups at position 3 of an invariable 3-desoxyestrone (dE1) moiety were tested in vitro as inhibitors of the human placental sterylsulfatase. Using both placental micro
Publikováno v:
Polycyclic Aromatic Compounds. 6:275-282
Catecholestrogens (CE), namely 2-hydroxyestradiol (2-OH-E2) and 4-hydroxyestradiol (4-OH-E2), are important, naturally occurring metabolites of E2. We studied their role on estrogen dependent processes using the MCF-7 cell line as a model system. Inc
Publikováno v:
The Prostate. 25:81-90
Tenascin is a glycoprotein of the extracellular matrix of mesenchymal derived tissue compartments. Although the DNA sequences that code for tenascin production are known and the protein structure is well characterized, little is known about regulatio
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 49:167-171
Isolated cytotrophoblast cells and choriocarcinoma cell lines are commonly applied in-vitro systems for the study of human placental endocrine function. We tested these normal and transformed placental cells for expression of the enzyme sterylsulfata
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 48:453-461
The catecholestrogens, namely 2-hydroxyestradiol (2-OH-E2) and 4-hydroxyestradiol (4-OH-E2) are important, naturally occurring metabolites of E2. Here we studied their role on estrogen dependent processes. Using the MCF-7 cell line as a model system
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 48:487-494
We were previously investigating the expression of the extracellular matrix glycoprotein tenascin in normal and malignant endometrial tissues of humans and rodents. These studies suggested that the expression of tenascin was induced by proliferating
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 46:781-789
Catecholestrogens are important metabolites of estradiol and estrone in the human. Considerable interest has focused on the catecholestrogens 2-hydroxy- and 4-hydroxyestradiol since they bind to the estrogen receptor with an affinity in the range of
Autor:
Gurcharan S. Pahwa, F. Oberheuser, H. Dilling, G. Emons, T. Wetterling, Rudolf Knuppen, Olaf Ortmann, U. Löhrs
Publikováno v:
Geburtshilfe und Frauenheilkunde. 52:487-493
A 65-year old patient, suspected to be suffering from an androgen producing ovarian tumour, was treated preoperatively with the GnRH agonist triptorelin (500 micrograms/day s.c.) for 7 days. After an initial rise, gonadotrophin levels were suppressed