Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Rudolf Karch"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 3920-3932 (2023)
Molecular mechanisms within the checkpoint receptor PD-1 are essential for its activation by PD-L1 as well as for blocking such an activation via checkpoint inhibitors. We use molecular dynamics to scrutinize patterns of atomic motion in PD-1 without
Externí odkaz:
https://doaj.org/article/c54a2b747fec45e38002acebf705c7b7
Publikováno v:
BMC Immunology, Vol 23, Iss S1, Pp 1-13 (2022)
Abstract Background Major histocompatibility complexes (MHCs) play a crucial role in the cell-mediated adaptive immune response as they present antigenic peptides (p) which are recognized by host T cells through a complex formation of the T cell rece
Externí odkaz:
https://doaj.org/article/6a42a0c470124e409f9ccf6718879fd1
Autor:
Michael Kenn, Rudolf Karch, Lisa Tomasiak, Michael Cibena, Georg Pfeiler, Heinz Koelbl, Wolfgang Schreiner
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Cells in danger of being erroneously attacked by leucocytes express PD-L1 on their surface. These cells activate PD-1 on attacking leucocytes and send them to death, thus curbing erroneous, autoimmune attack. Unfortunately, cancer cells exploit this
Externí odkaz:
https://doaj.org/article/db95e544e347445885d9880ecd08569a
Autor:
Michael Kenn, Dan Cacsire Castillo-Tong, Christian F. Singer, Rudolf Karch, Michael Cibena, Heinz Koelbl, Wolfgang Schreiner
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Correctly estimating the hormone receptor status for estrogen (ER) and progesterone (PGR) is crucial for precision therapy of breast cancer. It is known that conventional diagnostics (immunohistochemistry, IHC) yields a significant rate of w
Externí odkaz:
https://doaj.org/article/db1c4ef44c7b4a4b8be90172f163f666
Autor:
Beatrix Wulkersdorfer, Martin Bauer, Rudolf Karch, Harald Stefanits, Cécile Philippe, Maria Weber, Thomas Czech, Marie-Claude Menet, Xavier Declèves, Johannes A. Hainfellner, Matthias Preusser, Marcus Hacker, Markus Zeitlinger, Markus Müller, Oliver Langer
Publikováno v:
EJNMMI Research, Vol 9, Iss 1, Pp 1-10 (2019)
Abstract Background P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) are two efflux transporters expressed at the blood–brain barrier which effectively restrict the brain distribution of the majority of currently known anticancer
Externí odkaz:
https://doaj.org/article/beb34f2037d5499f8f88efbca9a30902
Autor:
Myriam El Biali, Rudolf Karch, Cécile Philippe, Helmuth Haslacher, Nicolas Tournier, Marcus Hacker, Markus Zeitlinger, Doreen Schmidl, Oliver Langer, Martin Bauer
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The widely expressed and poly-specific ABC transporters breast cancer resistance protein (ABCG2) and P-glycoprotein (ABCB1) are co-localized at the blood-brain barrier (BBB) and have shown to limit the brain distribution of several clinically used AB
Externí odkaz:
https://doaj.org/article/b2d49507252745949da4a1005ca8ced1
Autor:
Xenia Simeone, Rudolf Karch, Anna Ciuraszkiewicz, Avi Orr‐Urtreger, Rosa Lemmens‐Gruber, Petra Scholze, Sigismund Huck
Publikováno v:
Physiological Reports, Vol 7, Iss 6, Pp n/a-n/a (2019)
Abstract Our previous immunoprecipitation analysis of nicotinic acetylcholine receptors (nAChRs) in the mouse superior cervical ganglion (SCG) revealed that approximately 55%, 24%, and 21% of receptors are comprised of α3β4, α3β4α5, and α3β4β
Externí odkaz:
https://doaj.org/article/8db8918b27374a7bbf7f4cf4bdad5a41
Publikováno v:
Cells, Vol 8, Iss 7, p 720 (2019)
The interaction of antigenic peptides (p) and major histocompatibility complexes (pMHC) with T-cell receptors (TCR) is one of the most important steps during the immune response. Here we present a molecular dynamics simulation study of bound and unbo
Externí odkaz:
https://doaj.org/article/2a71ddfd59d243759bc50949a1eb144b
Publikováno v:
Journal of Immunology Research, Vol 2015 (2015)
MHC α-helices form the antigen-binding cleft and are of particular interest for immunological reactions. To monitor these helices in molecular dynamics simulations, we applied a parsimonious fragment-fitting method to trace the axes of the α-helice
Externí odkaz:
https://doaj.org/article/8aa547bc6b3d4ba2ba36b3b12fd04579
Publikováno v:
Journal of Immunology Research, Vol 2015 (2015)
Molecular dynamics was used to simulate large molecules of the immune system (major histocompatibility complex class I, presented epitope, T-cell receptor, and a CD8 coreceptor.) To characterize the relative orientation and movements of domains local
Externí odkaz:
https://doaj.org/article/cc64c45325e94d1f81a34da37bb754cb