Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Rudolf K. A. Giger"'
Autor:
Ansgar Schuffenhauer, Ulrich Schopfer, Juergen Hinrichs, Caroline Engeloch, Benjamin Havill, Hans-Joerg Roth, Pierre Acklin, Friederike Stoll, Guido Koch, Edgar Jacoby, Pascal Rigollier, Maxim Popov, David Orain, Peter Meier, Kamal Azzaoui, Rudolf K. A. Giger, Juerg Zimmermann, Jaroslav Stanek, Karine Malagu
Publikováno v:
Current Topics in Medicinal Chemistry. 5:397-411
The NIBR (Novartis Institutes for BioMedical Research) compound collection enrichment and enhancement project integrates corporate internal combinatorial compound synthesis and external compound acquisition activities in order to build up a comprehen
Design and synthesis of a transition state analog of a metalloporphyrin-catalysed oxidation reaction
Autor:
Rudolf K. A. Giger, Pascal Hoffmann
Publikováno v:
Journal of Porphyrins and Phthalocyanines. :362-365
A hapten that mimics the transition state of a metalloporphyrin-catalysed oxidation reaction was synthesized in order to generate antibodies that might be able to catalyse the regioselective metalloporphyrin-co-catalysed reaction of cyclosporin A to
Autor:
Riccardo Canova, Regis Denay, Guido Koch, Michele Dattilo, David Orain, Edgar Klöppner, Rudolf K. A. Giger
Publikováno v:
Synlett. 2002:1443-1446
The solution and solid-phase syntheses of a 3,9-diazabi-cyclo[3.3.1]non-6-en-2-one have been realised via sequential Dakin-West/Pictet-Spengler reactions.
Autor:
Hans-Jürgen Pfannkuche, Rudolf K. A. Giger, Buchheit Kh, Daniel Hoyer, Klöppner E, Gamse R, Henri Mattes, F. Klein
Publikováno v:
Journal of Medicinal Chemistry. 38:2331-2338
A number of substituted indole carbazimidamides were prepared and evaluated as 5-HT 4 receptor agonists by using the isolated field-stimulated guinea pig ileum preparation. Their selectivity for the 5-HT 4 receptor was established by examining their
Autor:
Rudolf K. A. Giger, Riccardo Canova, Michele Dattilo, Regis Denay, David Orain, Edgar Kloeppner, Guido Koch
Publikováno v:
ChemInform. 33
Publisher Summary Tegaserod (HTF919; Zelnorm ® /Zelmac ® ) is an innovative and potent partial agonist at 5-HT 4 receptors, which mediate multiple physiological functions in the gastrointestinal (GI) tract. The compound is a representative of a new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e87919438654d877920c8916d33abf34
https://doi.org/10.1016/s0065-7743(07)42013-9
https://doi.org/10.1016/s0065-7743(07)42013-9
Autor:
Rudolf K. A. Giger, Gunter Engel
Publikováno v:
CHIMIA, Vol 60, Iss 1-2 (2006)
The scientific research on ergot alkaloids is fundamentally related to the work of Dr. Albert Hofmann, who was able to produce, from 1935 onwards, a number of novel and valuable drugs, some of which are still in use today. The complex chemical struct
Publikováno v:
ChemInform. 35
The core structure of a natural product was selected as scaffold for combinatorial library synthesis. The key step for the construction of the 3,9-diazabicyclo[3.3.1]non-6-ene core is a novel Dakin-West/Pictet-Spengler reaction sequence. Route select
Publikováno v:
CHIMIA, Vol 57, Iss 5 (2003)
The core structure of a natural product was selected as scaffold for combinatorial library synthesis. The key step for the construction of the 3,9-diazabicyclo[3.3.1]non-6-ene core is a novel Dakin-West/Pictet-Spengler reaction sequence. Route select
Publikováno v:
Organic letters. 4(26)
[reaction: see text] The synthesis of an indole diazabicyclo[3.2.2]nonedione derivative was achieved in a few steps starting from L-tryptophan. Reduction with borane-THF complex leads to fragmentation of the bicycle and the stereoselective formation