Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Rudolf Herbst"'
Autor:
Johanna Matull, Jan-Malte Placke, Georg Lodde, Anne Zaremba, Jochen Utikal, Patrick Terheyden, Claudia Pföhler, Rudolf Herbst, Alexander Kreuter, Julia Welzel, Julia Kretz, Inga Möller, Antje Sucker, Annette Paschen, Elisabeth Livingstone, Lisa Zimmer, Eva Hadaschik, Selma Ugurel, Dirk Schadendorf, Carl Maximilian Thielmann, Klaus Georg Griewank
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundScreening for gene mutations has become routine clinical practice across numerous tumor entities, including melanoma. BAP1 gene mutations have been identified in various tumor types and acknowledged as a critical event in metastatic uveal m
Externí odkaz:
https://doaj.org/article/ffb5dcdffd0f4202acd393d8e273a129
Autor:
Dirk Schadendorf, Carola Berking, Lisa Zimmer, Ralf Gutzmer, Alexander Kreuter, Andrea Forschner, Elisabeth Livingstone, Bastian Schilling, Selma Ugurel, Peter Mohr, Jessica Hassel, Patrick Terheyden, Henner Stege, Katharina Kaehler, Sebastian Haferkamp, Friedegund Meier, Claudia Pfoehler, Dirk Debus, Rudolf Herbst, Carmen Loquai, Frank Meiss, Martin Kaatz, Jens Ulrich, Edgar Dippel, Michael Weichenthal, Ulrike Leiter, Markus V Heppt, Michael Sachse, Fabian Ziller, Stephan Grabbe, Georg Lodde, Maximilian Haist, Friederike Rogall, Yuqi Tan, Kai Christian Klespe, Michael Tronnier, Imke von Wasielewski, Felix Kieker, Christopher Gebhardt, Jan Simon
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/85987b665cf74916884422bf2059f401
Autor:
Jan-Malte Placke, Mona Kimmig, Klaus Griewank, Rudolf Herbst, Patrick Terheyden, Jochen Utikal, Claudia Pföhler, Jens Ulrich, Alexander Kreuter, Peter Mohr, Ralf Gutzmer, Friedegund Meier, Edgar Dippel, Julia Welzel, Daniel Robert Engel, Sophia Kreft, Antje Sucker, Georg Lodde, Frederik Krefting, Ingo Stoffels, Joachim Klode, Alexander Roesch, Lisa Zimmer, Elisabeth Livingstone, Eva Hadaschik, Jürgen C. Becker, Michael Weichenthal, Alpaslan Tasdogan, Dirk Schadendorf, Selma Ugurel
Publikováno v:
EBioMedicine, Vol 96, Iss , Pp 104774- (2023)
Summary: Background: PD-1-based immune checkpoint inhibition (ICI) is the major backbone of current melanoma therapy. Tumor PD-L1 expression represents one of few biomarkers predicting ICI therapy outcome. The objective of the present study was to sy
Externí odkaz:
https://doaj.org/article/2d744a8eed3741f3b79556e7478f0af0
Autor:
Dirk Schadendorf, Carola Berking, Jessica C Hassel, Lisa Zimmer, Ralf Gutzmer, Alexander Kreuter, Andrea Forschner, Bastian Schilling, Selma Ugurel, Katharina C Kähler, Peter Mohr, Patrick Terheyden, Felix Kiecker, Henner Stege, Sebastian Haferkamp, Friedegund Meier, Claudia Pfoehler, Dirk Debus, Rudolf Herbst, Carmen Loquai, Frank Meiss, Martin Kaatz, Jens Ulrich, Edgar Dippel, Michael Weichenthal, Axel Hauschild, Ulrike Leiter, Markus V Heppt, Christoffer Gebhardt, Michael Sachse, Fabian Ziller, Stephan Grabbe, Georg Lodde, Maximilian Haist, Friederike Rogall, Yuqi Tan, Imke von Wasielewski, Kai Christian Klespe, Michael Tronnier, Jan Christoph Simon
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 9 (2023)
Background Adjuvant therapy with immune-checkpoint inhibitors (CPI) or BRAF/MEK-directed targeted therapy (TT) improves recurrence-free survival (RFS) for patients with advanced, BRAFV600-mutant (BRAFmut) resected melanoma. However, 40% of these pati
Externí odkaz:
https://doaj.org/article/b02d789393944e89a582fe64cc6e6ada
Autor:
Lucie Heinzerling, Lisa Zimmer, Ralf Gutzmer, Andrea Forschner, Elisabeth Livingstone, Bastian Schilling, Selma Ugurel, Peter Mohr, Thilo Gambichler, Patrick Terheyden, Sebastian Haferkamp, Dirk Debus, Rudolf Herbst, Carmen Loquai, Frank Meiss, Carsten Weishaupt, Martin Kaatz, Jens Ulrich, Edgar Dippel, Michael Weichenthal, Maike Trommer, Jürgen Christian Becker, Ulrike Leiter, Cindy Franklin, Christoffer Gebhardt, Katharina Kahler, Leonie Bluhm, Imke Grimmelmann, Marlene Garzarolli, Dorothee Nashan, Michael Sachse, Julia Welzel, Gerhard Weyandt, Susanne Horn, Fabian Ziller, Harald Löffler, Stephan Grabbe, Gaston Schley, Georg Lodde, Jan-Malte Placke, Anca Sindrilaru
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 4 (2023)
Background Despite the availability of effective systemic therapies, a significant number of advanced melanoma patients develops brain metastases. This study investigated differences in incidence and time to diagnosis of brain metastasis and survival
Externí odkaz:
https://doaj.org/article/78c357556a7d4fdbba1d2ae0e5644ffc
Autor:
Dirk Schadendorf, Lucie Heinzerling, Lisa Zimmer, Ralf Gutzmer, Alexander Kreuter, Andrea Forschner, Elisabeth Livingstone, Selma Ugurel, Alexander Roesch, Peter Mohr, Thilo Gambichler, Patrick Terheyden, Sebastian Haferkamp, Friedegund Meier, Claudia Pfoehler, Dirk Debus, Rudolf Herbst, Frank Meiss, Carsten Weishaupt, Jochen Utikal, Martin Kaatz, Jens Ulrich, Edgar Dippel, Michael Weichenthal, Maike Trommer, Ulrike Leiter, Kerstin Schatton, Cindy Franklin, Leonie Bluhm, Imke Grimmelmann, Marlene Garzarolli, Dorothee Nashan, Michael Sachse, Julia Welzel, Gerhard Weyandt, Eren Celik, Iris Helfrich, Susanne Horn
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 6 (2022)
Externí odkaz:
https://doaj.org/article/31d907c2fd3a4ebe9ebbc4ec2bbec6d3
Autor:
Martin Kaatz, Peter Mohr, Elisabeth Livingstone, Michael Weichenthal, Alexander Kreuter, Claudia Pföhler, Ulrike Leiter, Jens Ulrich, Jochen Sven Utikal, Ralf Gutzmer, Rudolf Herbst, Dirk Schadendorf
Publikováno v:
Acta Dermato-Venereologica, Vol 102 (2022)
Most patients with advanced basal cell carcinomas (BCCs) may not benefit sufficiently from standard treatment comprising surgery and radiation. Vismodegib, an oral selective hedgehog pathway inhibitor, is approved for treatment of patients with local
Externí odkaz:
https://doaj.org/article/a3c3ac9b536a4c41ab20bf32d592e730
Autor:
Jan-Malte Placke, Camille Soun, Jenny Bottek, Rudolf Herbst, Patrick Terheyden, Jochen Utikal, Claudia Pföhler, Jens Ulrich, Alexander Kreuter, Christiane Pfeiffer, Peter Mohr, Ralf Gutzmer, Friedegund Meier, Edgar Dippel, Michael Weichenthal, Lisa Zimmer, Elisabeth Livingstone, Jürgen C. Becker, Georg Lodde, Antje Sucker, Klaus Griewank, Susanne Horn, Eva Hadaschik, Alexander Roesch, Dirk Schadendorf, Daniel Robert Engel, Selma Ugurel
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
BackgroundPD-1-based immune checkpoint blockade (ICB) is a highly effective therapy in metastatic melanoma. However, 40-60% of patients are primarily resistant, with valid predictive biomarkers currently missing. This study investigated the digitally
Externí odkaz:
https://doaj.org/article/967680da967d4d1da0a6265a5de347ab
Autor:
Carola Berking, Jessica C Hassel, Lisa Zimmer, Ralf Gutzmer, Teresa Amaral, Thomas Eigentler, Claus Garbe, Julia Tietze, Thilo Gambichler, Patrick Terheyden, Felix Kiecker, Sarah Schaefer, Henner Stege, Katharina Kaehler, Sebastian Haferkamp, Jochen Uttikal, David Rafei-Shamsabadi, Lydia Reinhardt, Friedegund Meier, Ante Karoglan, Christian Posch, Claudia Pfoehler, Kai Thoms, Dirk Debus, Rudolf Herbst, Steffen Emmert, Carmen Loquai, Frank Meiss, Thomas Tueting, Vanessa Heinrich
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Background Nivolumab combined with ipilimumab have shown activity in melanoma brain metastasis (MBM). However, in most of the clinical trials investigating immunotherapy in this subgroup, patients with symptomatic MBM and/or prior local brain radioth
Externí odkaz:
https://doaj.org/article/1da3310c8b1b40ca8b61e76efd7b29f5
Autor:
Dirk Schadendorf, Carola Berking, Lucie Heinzerling, Lisa Zimmer, Ralf Gutzmer, Alexander Kreuter, Andreas Stang, Elisabeth Livingstone, Benjamin Weide, Eleftheria Chorti, Selma Ugurel, Anja Gesierich, Jürgen C Becker, Peter Mohr, Max Schlaak, Patrick Terheyden, Janine Gronewold, Rudolf Herbst, Carmen Loquai, Sarah Knispel, Hildegard Lax, Carsten Weishaupt, Claudia Pföhler, Katharina C Kaehler, Jochen Utikal, Martin Kaatz, Jens Ulrich, Edgar Dippel, Michael Weichenthal
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Background Immune checkpoint inhibition (ICI) is an essential treatment option in melanoma. Its outcome may be improved by a preceding radiation of metastases. This study aimed to investigate the impact of a preceding radiotherapy on the clinical out
Externí odkaz:
https://doaj.org/article/88535c53b95b4637b1aed1641c90cbb3