Zobrazeno 1 - 10
of 168
pro vyhledávání: '"Rudolf E Leube"'
Autor:
Florian Geisler, Sanne Remmelzwaal, Vera Jankowski, Ruben Schmidt, Mike Boxem, Rudolf E Leube
Publikováno v:
eLife, Vol 12 (2023)
Intermediate filaments (IFs) are major components of the metazoan cytoskeleton. A long-standing debate concerns the question whether IF network organization only reflects or also determines cell and tissue function. Using Caenorhabditis elegans, we h
Externí odkaz:
https://doaj.org/article/f1dc74546afd4969b89eb036bf0b9e2c
Autor:
Reinhard Windoffer, Nicole Schwarz, Sungjun Yoon, Teodora Piskova, Michael Scholkemper, Johannes Stegmaier, Andrea Bönsch, Jacopo Di Russo, Rudolf E Leube
Publikováno v:
eLife, Vol 11 (2022)
Mechanobiology requires precise quantitative information on processes taking place in specific 3D microenvironments. Connecting the abundance of microscopical, molecular, biochemical, and cell mechanical data with defined topologies has turned out to
Externí odkaz:
https://doaj.org/article/50fb01ad91fe48489f219c6b23955416
Autor:
Marcin Moch, Reinhard Windoffer, Nicole Schwarz, Raphaela Pohl, Andreas Omenzetter, Uwe Schnakenberg, Fabian Herb, Kraisorn Chaisaowong, Dorit Merhof, Lena Ramms, Gloria Fabris, Bernd Hoffmann, Rudolf Merkel, Rudolf E Leube
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0149106 (2016)
The keratin intermediate filament cytoskeleton protects epithelial cells against various types of stress and is involved in fundamental cellular processes such as signaling, differentiation and organelle trafficking. These functions rely on the cell
Externí odkaz:
https://doaj.org/article/1009d6287d6f4d4d903dd7f9de09277f
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121090 (2015)
Keratin are among the most abundant proteins in epithelial cells. Functions of the keratin network in cells are shaped by their dynamical organization. Using a collection of experimentally-driven mathematical models, different hypotheses for the turn
Externí odkaz:
https://doaj.org/article/8c498fb49fab471c95adce844d6945a1
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45280 (2012)
Altered cell motility is considered to be a key factor in determining tumor invasion and metastasis. Epidermal growth factor (EGF) signaling has been implicated in this process by affecting cytoskeletal organization and dynamics in multiple ways. To
Externí odkaz:
https://doaj.org/article/1f0a999644474193a7a64740eeaae1e7
Autor:
Annika Gross, Biaohuan Zhou, Lisa Bewersdorf, Nicole Schwarz, Gabriel M. Schacht, Peter Boor, Konrad Hoeft, Bernd Hoffmann, Elaine Fuchs, Rafael Kramann, Rudolf Merkel, Rudolf E. Leube, Pavel Strnad
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 4, Pp 1181-1200 (2022)
Background & Aims: Desmosomes are intercellular junctions connecting keratin intermediate filaments of neighboring cells. The cadherins desmoglein 2 (Dsg2) and desmocollin 2 mediate cell–cell adhesion, whereas desmoplakin (Dsp) provides the attachm
Externí odkaz:
https://doaj.org/article/81482cea13794afab6f7928cf210e021
Autor:
Evangéline Despin-Guitard, Ronan Quenec’Hdu, Wallis Nahaboo, Nicole Schwarz, Rudolf E. Leube, Claire Chazaud, Isabelle Migeotte
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The mechanical properties of the different germ layers of the early mammalian embryo are likely to be critical for morphogenesis. Cytoskeleton components (actin and myosin, microtubules, intermediate filaments) are major determinants of epithelial pl
Externí odkaz:
https://doaj.org/article/f746ed3927ff46ad8e4a9bfc52eda0f3
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Cardiac morphogenesis relies on intricate intercellular signaling. Altered signaling impacts cardiac function and is detrimental to embryonic survival. Here we report an unexpected regulatory role of the desmosomal cell adhesion molecule des
Externí odkaz:
https://doaj.org/article/dc4cad01069749ef8b5965c5b6a52231
Publikováno v:
Cells, Vol 11, Iss 19, p 3077 (2022)
Keratins exert important structural but also cytoprotective functions. They have to be adaptable to support cellular homeostasis. Epiplakin (EPPK1) has been shown to decorate keratin filaments in epithelial cells and to play a protective role under s
Externí odkaz:
https://doaj.org/article/6e96362ce5584545aa74d0c7c5a6d7b2
Publikováno v:
Cells, Vol 11, Iss 1, p 96 (2021)
Arrhythmogenic cardiomyopathy (AC) is a heritable, potentially lethal disease without a causal therapy. AC is characterized by focal cardiomyocyte death followed by inflammation and progressive formation of connective tissue. The pathomechanisms lead
Externí odkaz:
https://doaj.org/article/902dbe98b9fb48ba9460d2d2a2c2a3bb