Zobrazeno 1 - 10
of 257
pro vyhledávání: '"Rudolf E Leube"'
Autor:
Larissa Fabritz, Lisa Fortmueller, Katja Gehmlich, Sebastian Kant, Marcel Kemper, Dana Kucerova, Fahima Syeda, Cornelius Faber, Rudolf E. Leube, Paulus Kirchhof, Claudia A. Krusche
Publikováno v:
Biomedicines, Vol 12, Iss 5, p 985 (2024)
Desmoglein-2 mutations are detected in 5–10% of patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). Endurance training accelerates the development of the ARVC phenotype, leading to earlier arrhythmic events. Homozygous Dsg2 mutant
Externí odkaz:
https://doaj.org/article/5a5105ab2727484b917460f3f967de2c
Autor:
Florian Geisler, Sanne Remmelzwaal, Vera Jankowski, Ruben Schmidt, Mike Boxem, Rudolf E Leube
Publikováno v:
eLife, Vol 12 (2023)
Intermediate filaments (IFs) are major components of the metazoan cytoskeleton. A long-standing debate concerns the question whether IF network organization only reflects or also determines cell and tissue function. Using Caenorhabditis elegans, we h
Externí odkaz:
https://doaj.org/article/f1dc74546afd4969b89eb036bf0b9e2c
Autor:
Annika Gross, Biaohuan Zhou, Lisa Bewersdorf, Nicole Schwarz, Gabriel M. Schacht, Peter Boor, Konrad Hoeft, Bernd Hoffmann, Elaine Fuchs, Rafael Kramann, Rudolf Merkel, Rudolf E. Leube, Pavel Strnad
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 4, Pp 1181-1200 (2022)
Background & Aims: Desmosomes are intercellular junctions connecting keratin intermediate filaments of neighboring cells. The cadherins desmoglein 2 (Dsg2) and desmocollin 2 mediate cell–cell adhesion, whereas desmoplakin (Dsp) provides the attachm
Externí odkaz:
https://doaj.org/article/81482cea13794afab6f7928cf210e021
Autor:
Rudolf E. Leube, Roy A. Quinlan
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Externí odkaz:
https://doaj.org/article/e0c6fe79aded4a779613d9fda89a2f59
Autor:
Evangéline Despin-Guitard, Ronan Quenec’Hdu, Wallis Nahaboo, Nicole Schwarz, Rudolf E. Leube, Claire Chazaud, Isabelle Migeotte
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The mechanical properties of the different germ layers of the early mammalian embryo are likely to be critical for morphogenesis. Cytoskeleton components (actin and myosin, microtubules, intermediate filaments) are major determinants of epithelial pl
Externí odkaz:
https://doaj.org/article/f746ed3927ff46ad8e4a9bfc52eda0f3
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Cardiac morphogenesis relies on intricate intercellular signaling. Altered signaling impacts cardiac function and is detrimental to embryonic survival. Here we report an unexpected regulatory role of the desmosomal cell adhesion molecule des
Externí odkaz:
https://doaj.org/article/dc4cad01069749ef8b5965c5b6a52231
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Mechanical stability is a fundamental and essential property of epithelial cell sheets. It is in large part determined by cell-cell adhesion sites that are tightly integrated by the cortical cytoskeleton. An intimate crosstalk between the adherens ju
Externí odkaz:
https://doaj.org/article/5124db3c82ea4307bd06505b3c35b450
Publikováno v:
Cells, Vol 12, Iss 17, p 2122 (2023)
Desmosomes play a vital role in providing structural integrity to tissues that experience significant mechanical tension, including the heart. Deficiencies in desmosomal proteins lead to the development of arrhythmogenic cardiomyopathy (AC). The limi
Externí odkaz:
https://doaj.org/article/c61287d2c9e2452296107bff0b19542b
Autor:
Sungjun Yoon, Reinhard Windoffer, Aleksandra N. Kozyrina, Teodora Piskova, Jacopo Di Russo, Rudolf E. Leube
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Keratin intermediate filaments are dynamic cytoskeletal components that are responsible for tuning the mechanical properties of epithelial tissues. Although it is known that keratin filaments (KFs) are able to sense and respond to changes in the phys
Externí odkaz:
https://doaj.org/article/7e78b7c5f0e64b88bdcc20b951fa9db6
Autor:
Reinhard Windoffer, Nicole Schwarz, Sungjun Yoon, Teodora Piskova, Michael Scholkemper, Johannes Stegmaier, Andrea Bönsch, Jacopo Di Russo, Rudolf E Leube
Publikováno v:
eLife, Vol 11 (2022)
Mechanobiology requires precise quantitative information on processes taking place in specific 3D microenvironments. Connecting the abundance of microscopical, molecular, biochemical, and cell mechanical data with defined topologies has turned out to
Externí odkaz:
https://doaj.org/article/50fb01ad91fe48489f219c6b23955416