Výsledky vyhledávání - "Rudolf Babic"

Minimal Residual Disease in Gastric Cancer: Evidence of an Independent Prognostic Relevance of Urokinase Receptor Expression by Disseminated Tumor Cells in the Bone Marrow

Autor: Markus M. Heiss, Klaus Uwe Gruetzner, Rudolf Babic, Heike Allgayer, Bianca C.M. Beyer, Friedrich W. Schildberg, Anwar Tarabichi, Erich H. Simon

Publikováno v: Journal of Clinical Oncology. 20:2005-2016

PURPOSE: To study the invasion-related molecule urokinase-type plasminogen activator receptor (u-PAR) expressed by disseminated tumor cells as a biologic predictor of poor survival in a large prospective series of patients with gastric cancer. PATIEN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdb8da298f1d42da3afe75f6a2e819c5
https://doi.org/10.1200/jco.2002.08.003

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Clinical Value of Extended Biologic Staging by Bone Marrow Micrometastases and Tumor-Associated Proteases in Gastric Cancer

Autor: Karl-Walter Jauch, Friedrich W. Schildberg, Heike Allgayer, Markus M. Heiss, Klaus Uwe Gruetzner, Rudolf Babic

Publikováno v: Annals of Surgery. 226:736-745

OBJECTIVE: To investigate whether extended staging, including biologic grading and aspects of an early systemic disease component, would give additional prognostic information on patients with curatively resected gastric cancer. BACKGROUND: Tumor-ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98f52c5cf522bbdc5e5ddd82a32ac01b
https://doi.org/10.1097/00000658-199712000-00010

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An immunohistochemical assessment of cathepsin D in gastric carcinoma

Autor: Bianca C. M. Beyer, Heike Allgayer, Klaus Uwe Grützner, Anwar Tarabichi, Friedrich Wilhelm Schildberg, Rudolf Babic, M. M. Heiss

Publikováno v: Cancer. 80:179-187

BACKGROUND In the context of tumor-associated proteolysis, the prognostic value of cathepsin D in breast carcinoma has been studied but its role is controversial in relation to gastrointestinal carcinoma. The aim of the current study was to determine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7be649d964d1f3d2aacbe439b989bc68
https://doi.org/10.1002/(sici)1097-0142(19970715)80:2<179::aid-cncr2>3.0.co

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Immunocytochemical Phenotyping of Disseminated Tumor Cells in Bone Marrow by uPA Receptor and CK18: Investigation of Sensitivity and Specificity of an Immunogold/Alkaline Phosphatase Double Staining Protocol

Autor: Friedrich W. Schildberg, Heike Allgayer, Karl-Walter Jauch, Markus M. Heiss, Rainer Riesenberg, Rudolf Babic

Publikováno v: Journal of Histochemistry & Cytochemistry. 45:203-212

Phenotyping of cytokeratin (CK) 18-positive cells in bone marrow is gaining increasing importance for future prognostic screening of carcinoma patients. Urokinase-type plasminogen activator receptor (uPA-R) is one example of a potential aggressive ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::406b85faa211d6bf68862fbb655f8f74
https://doi.org/10.1177/002215549704500206

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[Untitled]

Autor: Bianca C.M. Beyer, Heike Allgayer, Klaus Uwe Grützner, Anwar Tarabichi, Rudolf Babic, Markus M. Heiss, Friedrich W. Schildberg

Publikováno v: Clinical and Experimental Metastasis. 16:62-73

Expression of proteolytic parameters of the urokinase-type plasminogen activator (uPA) system [uPA receptor (uPA-R), plasminogen activator inhibitor (PAI)-1] has been proven to be an independent prognostic parameter in cancer. However, it has not bee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::69d93af542c44c57019153b6e56a2622
https://doi.org/10.1023/a:1006564002679

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Prognostic significance of bone marrow micrometastases in patients with gastric cancer

Autor: Friedrich W. Schildberg, G Riethmueller, Ilona Funke, Markus M. Heiss, H J Eissner, Klaus Pantel, U Gruetzner, K. W. Jauch, Rudolf Babic

Publikováno v: Journal of Clinical Oncology. 14:1810-1817

BACKGROUND Monoclonal antibodies (mabs) against components of the cytoskeleton such as cytokeratins allow single disseminated epithelial carcinoma cells to be detected in the bone marrow. The aim of this study was to examine the prognostic relevance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461d0b8f2363796519ed629b3531a545
https://doi.org/10.1200/jco.1996.14.6.1810

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Expression of leukocyte cell adhesion molecules on gastric carcinomas: Possible involvement of lfa-3 expression in the development of distant metastases

Autor: Judith P. Johnson, Friedrich W. Schildberg, Karl W. Jauch, Rudolf Babic, Barbara Mayer, Ilona Funke, Claudia Lorenz

Publikováno v: International Journal of Cancer. 64:415-423

Expression of the cell adhesion molecules ICAM-1 (CD54) and LFA-3 (CD58) was examined on primary gastric carcinomas, autologous benign mucosa and metastatic lesions. Although ICAM-1 was never observed on benign gastric epithelium, even in the presenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb26c88e94a75b7d3d5993923bc95cb
https://doi.org/10.1002/ijc.2910640611

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Individual development and uPA–receptor expression of disseminated tumour cells in bone marrow: A reference to early systemic disease in solid cancer

Autor: Markus M. Heiss, Ilona Funke, Karl-Walter Jauch, Friedrich W. Schildberg, Klaus Uwe Gruetzner, Rudolf Babic, Heike Allgayer

Publikováno v: Nature Medicine. 1:1035-1039

It is unclear whether disseminated tumour cells detected in bone marrow in early stages of solid cancers indicate a subclinical systemic disease component determining the patient's fate or simply represent mainly irrelevant shed cells. Moreover, char

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185e58d8ec35cf751d35b56d965e781f
https://doi.org/10.1038/nm1095-1035

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Immunohistological studies of complement activation after xenogeneic perfusion of a working heart model

Autor: Michael Müdsam, Rudolf Babic, Markus M. SuckfÜll, Claus Hammer, Georg Enders, Oliver Pieske

Publikováno v: Transplant International. 7:324-328

Transplantation of organs from one species to another leads to immediate hyperacute rejection. Activation of complement is one important factor involved in this process. Whether complement activation is induced by preformed natural antibodies (PNAbs)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f31902017557fa19c816ef7bc6612f
https://doi.org/10.1007/bf00336706

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THE CONTRIBUTION OF ENDOTHELIAL CELLS TO HYPERACUTE REJECTION IN XENOGENEIC PERFUSED WORKING HEARTS

Autor: Rudolf Babic, Claus Hammer, Markus M. SuckfÜll, Oliver Pieske, Michael Müdsam

Publikováno v: Transplantation. 57:262-266

The mechanisms leading to the hyperacute rejection of a vascularized xenograft are still incompletely understood. The first stage of the rejection process is when blood of the recipient comes into contact with the endothelium of the xenograft. A work

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96eae2f9d3a696aa1bd3ace436b7fddb
https://doi.org/10.1097/00007890-199401001-00019

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