Zobrazeno 1 - 10 of 32 pro vyhledávání: '"Rudolf Andrýs"'
1
Akademický článek
Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer’s disease therapy
Autor: Irene Pachón-Angona, Bernard Refouvelet, Rudolf Andrýs, Helène Martin, Vincent Luzet, Isabel Iriepa, Ignacio Moraleda, Daniel Diez-Iriepa, María-Jesús Oset-Gasque, José Marco-Contelles, Kamil Musilek, Lhassane Ismaili
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 479-489 (2019)
We describe herein the design, multicomponent synthesis and biological studies of new donepezil + chromone + melatonin hybrids as potential agents for Alzheimer’s disease (AD) therapy. We have identified compound 14n as promising multitarget small
Externí odkaz: https://doaj.org/article/0bac54c2f9864ac794fb57250198766b
Zobrazit plný text záznamu
2
Akademický článek
A Complex In Vitro Degradation Study on Polydioxanone Biliary Stents during a Clinically Relevant Period with the Focus on Raman Spectroscopy Validation
Autor: Jan Loskot, Daniel Jezbera, Zuzana Olmrová Zmrhalová, Martina Nalezinková, Dino Alferi, Krisztina Lelkes, Petr Voda, Rudolf Andrýs, Alena Myslivcová Fučíková, Tomáš Hosszú, Aleš Bezrouk
Publikováno v: Polymers, Vol 14, Iss 5, p 938 (2022)
Biodegradable biliary stents are promising treatments for biliary benign stenoses. One of the materials considered for their production is polydioxanone (PPDX), which could exhibit a suitable degradation time for use in biodegradable stents. Proper m
Externí odkaz: https://doaj.org/article/061099967a1144a6b4261124030698ea
Zobrazit plný text záznamu
3
Akademický článek
Raman Spectroscopy as a Novel Method for the Characterization of Polydioxanone Medical Stents Biodegradation
Autor: Jan Loskot, Daniel Jezbera, Aleš Bezrouk, Rafael Doležal, Rudolf Andrýs, Vendula Francová, Dominik Miškář, Alena Myslivcová Fučíková
Publikováno v: Materials, Vol 14, Iss 18, p 5462 (2021)
Polydioxanone (PPDX), as an FDA approved polymer in tissue engineering, is an important component of some promising medical devices, e.g., biodegradable stents. The hydrolytic degradation of polydioxanone stents plays a key role in the safety and eff
Externí odkaz: https://doaj.org/article/34d68541136540a294480aa821ba74f4
Zobrazit plný text záznamu
4
Akademický článek
Amaryllidaceae Alkaloids of Norbelladine-Type as Inspiration for Development of Highly Selective Butyrylcholinesterase Inhibitors: Synthesis, Biological Activity Evaluation, and Docking Studies
Autor: Abdullah Al Mamun, Filip Pidaný, Daniela Hulcová, Jana Maříková, Tomáš Kučera, Monika Schmidt, Maria Carmen Catapano, Martina Hrabinová, Daniel Jun, Lubica Múčková, Jiří Kuneš, Jiří Janoušek, Rudolf Andrýs, Lucie Nováková, Rozálie Peřinová, Negar Maafi, Ondřej Soukup, Jan Korábečný, Lucie Cahlíková
Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 15, p 8308 (2021)
Alzheimer’s disease (AD) is a multifactorial neurodegenerative condition of the central nervous system (CNS) that is currently treated by cholinesterase inhibitors and the N-methyl-d-aspartate receptor antagonist, memantine. Emerging evidence stron
Externí odkaz: https://doaj.org/article/86aedb8c775643fd867b3536101e7ecd
Zobrazit plný text záznamu
6
Encapsulation of oxime acetylcholinesterase reactivators: influence of physiological conditions on the stability of oxime-cucurbit[7]uril complexes
Autor: Rudolf Andrýs, Aneta Klusoňová, Miroslav Lísa, Jana Žd'árová Karasová
Publikováno v: New Journal of Chemistry. 44:14367-14372
Oxime-based acetylcholinesterase reactivators are a specific group of drugs used for the treatment of organophosphate intoxication. However, high hydrophilicity and poor blood–brain barrier penetration limit their physiological potential. Cucurbit[
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ca4caa4fdff8a5f7927252ba6549abc0
https://doi.org/10.1039/d0nj03102j
Zobrazit plný text záznamu
7
A systematic evaluation of the cucurbit[7]uril pharmacokinetics and toxicity after a single dose and short-term repeated administration in mice
Autor: Jaroslav Pejchal, Petr Jošt, Lubica Múčková, Rudolf Andrýs, Miroslav Lísa, Jana Zdarova Karasova
Publikováno v: Archives of toxicology. 96(5)
Cucurbit[n]urils are macrocyclic compounds capable of forming host-guest complexes with different molecules. In this study, we focused on cucurbit[7]uril (CB[7]) safety and pharmacokinetics. We investigated CB[7] cytotocixity in human renal cells ACH
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::199ef8c44b57b21674ed53be35b2e3bb
https://pubmed.ncbi.nlm.nih.gov/35220471
Zobrazit plný text záznamu
8
Amaryllidaceae Alkaloids of Norbelladine-Type as Inspiration for Development of Highly Selective Butyrylcholinesterase Inhibitors: Synthesis, Biological Activity Evaluation, and Docking Studies
Autor: Ondřej Soukup, Filip Pidaný, Rozálie Peřinová, Lubica Muckova, Jiří Kuneš, Tomas Kucera, Abdullah Al Mamun, Negar Maafi, Jan Korábečný, Rudolf Andrýs, Monika Schmidt, Jiří Janoušek, Martina Hrabinova, Jana Maříková, Lucie Cahlíková, Daniela Hulcová, Daniel Jun, Lucie Nováková, Maria Carmen Catapano
Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 8308, p 8308 (2021)
Volume 22
Issue 15
Alzheimer’s disease (AD) is a multifactorial neurodegenerative condition of the central nervous system (CNS) that is currently treated by cholinesterase inhibitors and the N-methyl-d-aspartate receptor antagonist, memantine. Emerging evidence stron
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b3cebbc8a61c4dc47135856a4bd8db0
https://pubmed.ncbi.nlm.nih.gov/34361074
Zobrazit plný text záznamu
10
Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer’s disease therapy
Autor: Vincent Luzet, José Marco-Contelles, Kamil Musilek, Irene Pachón-Angona, Isabel Iriepa, Hélène Martin, María-Jesús Oset-Gasque, Daniel Diez-Iriepa, Rudolf Andrýs, Ignacio Moraleda, Bernard Refouvelet, Lhassane Ismaili
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 479-489 (2019)
Digital.CSIC. Repositorio Institucional del CSIC
instname
We describe herein the design, multicomponent synthesis and biological studies of new donepezil + chromone + melatonin hybrids as potential agents for Alzheimer’s disease (AD) therapy. We have identified compound 14n as promising multitarget small
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72641e085d496edc5d8aa40a9f816192
https://doi.org/10.1080/14756366.2018.1545766
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje