Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Rudolf Andrýs"'
Autor:
Oleksandr Kozlov, Eliška Horáková, Sára Rademacherová, Dávid Maliňák, Rudolf Andrýs, Eliška Prchalová, Miroslav Lísa
Publikováno v:
Analytical Chemistry. 95:5109-5116
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71d3ad548ed06d081ab43cd2a4f233ad
https://doi.org/10.1021/acs.analchem.3c00053
https://doi.org/10.1021/acs.analchem.3c00053
Autor:
Irene Pachón-Angona, Bernard Refouvelet, Rudolf Andrýs, Helène Martin, Vincent Luzet, Isabel Iriepa, Ignacio Moraleda, Daniel Diez-Iriepa, María-Jesús Oset-Gasque, José Marco-Contelles, Kamil Musilek, Lhassane Ismaili
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 479-489 (2019)
We describe herein the design, multicomponent synthesis and biological studies of new donepezil + chromone + melatonin hybrids as potential agents for Alzheimer’s disease (AD) therapy. We have identified compound 14n as promising multitarget small
Externí odkaz:
https://doaj.org/article/0bac54c2f9864ac794fb57250198766b
Autor:
Jan Loskot, Daniel Jezbera, Zuzana Olmrová Zmrhalová, Martina Nalezinková, Dino Alferi, Krisztina Lelkes, Petr Voda, Rudolf Andrýs, Alena Myslivcová Fučíková, Tomáš Hosszú, Aleš Bezrouk
Publikováno v:
Polymers; Volume 14; Issue 5; Pages: 938
Biodegradable biliary stents are promising treatments for biliary benign stenoses. One of the materials considered for their production is polydioxanone (PPDX), which could exhibit a suitable degradation time for use in biodegradable stents. Proper m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23dd4407a3342e3a243d0efc363ddce4
https://pubmed.ncbi.nlm.nih.gov/35267761
https://pubmed.ncbi.nlm.nih.gov/35267761
Autor:
Jaroslav Pejchal, Petr Jošt, Lubica Múčková, Rudolf Andrýs, Miroslav Lísa, Jana Zdarova Karasova
Publikováno v:
Archives of toxicology. 96(5)
Cucurbit[n]urils are macrocyclic compounds capable of forming host-guest complexes with different molecules. In this study, we focused on cucurbit[7]uril (CB[7]) safety and pharmacokinetics. We investigated CB[7] cytotocixity in human renal cells ACH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::199ef8c44b57b21674ed53be35b2e3bb
https://pubmed.ncbi.nlm.nih.gov/35220471
https://pubmed.ncbi.nlm.nih.gov/35220471
Autor:
Jan Loskot, Daniel Jezbera, Aleš Bezrouk, Rafael Doležal, Rudolf Andrýs, Vendula Francová, Dominik Miškář, Alena Myslivcová Fučíková
Publikováno v:
Materials
Volume 14
Issue 18
Materials, Vol 14, Iss 5462, p 5462 (2021)
Volume 14
Issue 18
Materials, Vol 14, Iss 5462, p 5462 (2021)
Polydioxanone (PPDX), as an FDA approved polymer in tissue engineering, is an important component of some promising medical devices, e.g., biodegradable stents. The hydrolytic degradation of polydioxanone stents plays a key role in the safety and eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4eac0c009c8be1b853965dc2a2aaa360
Publikováno v:
New Journal of Chemistry. 44:14367-14372
Oxime-based acetylcholinesterase reactivators are a specific group of drugs used for the treatment of organophosphate intoxication. However, high hydrophilicity and poor blood–brain barrier penetration limit their physiological potential. Cucurbit[
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca4caa4fdff8a5f7927252ba6549abc0
https://doi.org/10.1039/d0nj03102j
https://doi.org/10.1039/d0nj03102j
Autor:
Rafael Doležal, Jana Žďárová Karasová, Martin Novák, Natálie Karásková, Kamil Kuca, Karel Kolář, Iva Houdková, Nadezhda V. Maltsevskaya, Rudolf Andrýs, Eva Novotná, Huba Kalász
Publikováno v:
Analytical Letters. 52:1788-1812
Hypericin is one of the most important bioactive substances present in Hypericum perforatum (Saint John’s Wort), which exhibits various biological activities such as inhibition of neuronal ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adc1bfd68319a9651c0ef1de9f3237c8
https://doi.org/10.1080/00032719.2019.1571076
https://doi.org/10.1080/00032719.2019.1571076
Autor:
Ondřej Soukup, Filip Pidaný, Rozálie Peřinová, Lubica Muckova, Jiří Kuneš, Tomas Kucera, Abdullah Al Mamun, Negar Maafi, Jan Korábečný, Rudolf Andrýs, Monika Schmidt, Jiří Janoušek, Martina Hrabinova, Jana Maříková, Lucie Cahlíková, Daniela Hulcová, Daniel Jun, Lucie Nováková, Maria Carmen Catapano
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 8308, p 8308 (2021)
Volume 22
Issue 15
International Journal of Molecular Sciences, Vol 22, Iss 8308, p 8308 (2021)
Volume 22
Issue 15
Alzheimer’s disease (AD) is a multifactorial neurodegenerative condition of the central nervous system (CNS) that is currently treated by cholinesterase inhibitors and the N-methyl-d-aspartate receptor antagonist, memantine. Emerging evidence stron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b3cebbc8a61c4dc47135856a4bd8db0
https://pubmed.ncbi.nlm.nih.gov/34361074
https://pubmed.ncbi.nlm.nih.gov/34361074
Publikováno v:
Molecular pharmaceutics. 18(6)
Oxime-based molecules are used for the treatment of patients to reactivate acetylcholinesterase (AChE) function after organophosphate intoxication. However, their efficacy is limited by low penetration through the blood-brain barrier and fast elimina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd5a764511faea8745ae587135afc96b
https://pubmed.ncbi.nlm.nih.gov/34019427
https://pubmed.ncbi.nlm.nih.gov/34019427
Autor:
Lucie Zemanová, Vladimír Wsól, Jerzy Adamski, Marc Meier, Miroslav Šafr, Kristýna Šperková, Eva Novotná, Jiří Andrejs, Rudolf Andrýs, Gabriele Möller, Klára Kozáková, Hana Navrátilová
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 185:80-89
Many enzymes from the short-chain dehydrogenase/reductase superfamily (SDR) have already been well characterized, particularly those that participate in crucial biochemical reactions in the human body (e.g. 11β-hydroxysteroid dehydrogenase 1, 17β-h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e5ac2b97ffbf78446c52b8869f281b
https://doi.org/10.1016/j.jsbmb.2018.07.013
https://doi.org/10.1016/j.jsbmb.2018.07.013