Zobrazeno 1 - 10
of 291
pro vyhledávání: '"Rudolf, Zechner"'
Autor:
Natalia Kulminskaya, Carlos Francisco Rodriguez Gamez, Peter Hofer, Ines Kathrin Cerk, Noopur Dubey, Roland Viertlmayr, Theo Sagmeister, Tea Pavkov-Keller, Rudolf Zechner, Monika Oberer
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 8, Pp 100613- (2024)
Externí odkaz:
https://doaj.org/article/fcc82e1adae34ab0ba680e5723a70c49
Autor:
Natalia Kulminskaya, Carlos Francisco Rodriguez Gamez, Peter Hofer, Ines Kathrin Cerk, Noopur Dubey, Roland Viertlmayr, Theo Sagmeister, Tea Pavkov-Keller, Rudolf Zechner, Monika Oberer
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 1, Pp 100491- (2024)
Lipolysis is an essential metabolic process that releases unesterified fatty acids from neutral lipid stores to maintain energy homeostasis in living organisms. Adipose triglyceride lipase (ATGL) plays a key role in intracellular lipolysis and can be
Externí odkaz:
https://doaj.org/article/aa096cc53e4e4f6a87eb1ee3710210b5
Autor:
Peter Hofer, Gernot F. Grabner, Mario König, Hao Xie, Dominik Bulfon, Anton E. Ludwig, Heimo Wolinski, Robert Zimmermann, Rudolf Zechner, Christoph Heier
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 11, Pp 100457- (2023)
Intracellular lipolysis—the enzymatic breakdown of lipid droplet-associated triacylglycerol (TAG)—depends on the cooperative action of several hydrolytic enzymes and regulatory proteins, together designated as lipolysome. Adipose triglyceride lip
Externí odkaz:
https://doaj.org/article/bfc34bab37db460bab35c37681986747
Autor:
Isabella Pototschnig, Ursula Feiler, Clemens Diwoky, Paul W. Vesely, Thomas Rauchenwald, Margret Paar, Latifa Bakiri, Laura Pajed, Peter Hofer, Karl Kashofer, Nyamdelger Sukhbaatar, Gabriele Schoiswohl, Thomas Weichhart, Gerald Hoefler, Christoph Bock, Martin Pichler, Erwin F. Wagner, Rudolf Zechner, Martina Schweiger
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 1, Pp 93-107 (2023)
Abstract Background Cancer‐associated cachexia (CAC) is a wasting syndrome drastically reducing efficacy of chemotherapy and life expectancy of patients. CAC affects up to 80% of cancer patients, yet the mechanisms underlying the disease are not we
Externí odkaz:
https://doaj.org/article/562eec85d9b4414fbcf6d13bb3bc9bf1
Autor:
Petra Kotzbeck, Ulrike Taschler, Christoph Haudum, Ines Foessl, Gabriele Schoiswohl, Beate Boulgaropoulos, Kaddour Bounab, Johanna Einsiedler, Laura Pajed, Anna Tilp, Anna Schwarz, Thomas O. Eichmann, Barbara Obermayer-Pietsch, Antonio Giordano, Saverio Cinti, Rudolf Zechner, Thomas R. Pieber
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 1, Pp 100305- (2023)
Hormone-sensitive lipase (HSL) plays a crucial role in intracellular lipolysis, and loss of HSL leads to diacylglycerol (DAG) accumulation, reduced FA mobilization, and impaired PPARγ signaling. Hsl knockout mice exhibit adipose tissue inflammation,
Externí odkaz:
https://doaj.org/article/80063204e648425484a550a793ab4a26
Autor:
Manu Manjunath Kanti, Isabelle Striessnig-Bina, Beatrix Irene Wieser, Silvia Schauer, Gerd Leitinger, Thomas O. Eichmann, Martina Schweiger, Margit Winkler, Elke Winter, Andrea Lana, Iris Kufferath, Leigh Matthew Marsh, Grazyna Kwapiszewska, Rudolf Zechner, Gerald Hoefler, Paul Willibald Vesely
Publikováno v:
JCI Insight, Vol 7, Iss 9 (2022)
The lung airways are constantly exposed to inhaled toxic substances, resulting in cellular damage that is repaired by local expansion of resident bronchiolar epithelial club cells. Disturbed bronchiolar epithelial damage repair lies at the core of ma
Externí odkaz:
https://doaj.org/article/6e55c1328618497586f1124ea9fb581b
Autor:
Gernot F. Grabner, Nermeen Fawzy, Maria A. Pribasnig, Markus Trieb, Ulrike Taschler, Michael Holzer, Martina Schweiger, Heimo Wolinski, Dagmar Kolb, Angela Horvath, Rolf Breinbauer, Thomas Rülicke, Roland Rabl, Achim Lass, Vanessa Stadlbauer, Birgit Hutter-Paier, Rudolf E. Stauber, Peter Fickert, Rudolf Zechner, Gunther Marsche, Thomas O. Eichmann, Robert Zimmermann
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 5, Pp 1020-1031 (2019)
Bis(monoacylglycerol)phosphate (BMP) is a phospholipid that is crucial for lipid degradation and sorting in acidic organelles. Genetic and drug-induced lysosomal storage disorders (LSDs) are associated with increased BMP concentrations in tissues and
Externí odkaz:
https://doaj.org/article/6811fbb03319497cbbdc699b457cff47
Autor:
Cecilie Hundahl, Petra Kotzbeck, Hayley B. Burm, Søren H. Christiansen, Lola Torz, Aske W. Helge, Martin P. Madsen, Cecilia Ratner, Annette K. Serup, Jonatan J. Thompson, Thomas O. Eichmann, Tune H. Pers, David P.D. Woldbye, Daniele Piomelli, Bente Kiens, Rudolf Zechner, Louise J. Skov, Birgitte Holst
Publikováno v:
Molecular Metabolism, Vol 47, Iss , Pp 101174- (2021)
Objective: The goal of this study was to investigate the importance of central hormone-sensitive lipase (HSL) expression in the regulation of food intake and body weight in mice to clarify whether intracellular lipolysis in the mammalian hypothalamus
Externí odkaz:
https://doaj.org/article/b4e606e56133422d9a7ea2b947c8d458
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 1, Pp 100001- (2020)
Heart failure is one of the leading causes of death worldwide. New therapeutic concepts are urgently required to lower the burden of heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF), the
Externí odkaz:
https://doaj.org/article/6c9f081f94b845588d332b343905b216
Autor:
Zhiyuan Tang, Hao Xie, Christoph Heier, Jianfei Huang, Qiuling Zheng, Thomas O. Eichmann, Gabriele Schoiswohl, Jun Ni, Rudolf Zechner, Songshi Ni, Haiping Hao
Publikováno v:
EBioMedicine, Vol 53, Iss , Pp - (2020)
Background: Tumor cells display metabolic changes that correlate with malignancy, including an elevated hydrolysis of monoacylglycerol (MAG) in various cancer types. However, evidence is absent for the relationship between MAG lipolysis and NSCLC. Me
Externí odkaz:
https://doaj.org/article/68a37357a4c54ac3baf1e9aad0beb0f1