Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Rudolf, Schicho"'
Autor:
Sandra Kendzia, Susanne Franke, Tarek Kröhler, Nicole Golob-Schwarzl, Caroline Schweiger, Anna M. Toeglhofer, Christina Skofler, Stefan Uranitsch, Amin El-Heliebi, Julia Fuchs, Andreas Punschart, Philipp Stiegler, Marlen Keil, Jens Hoffmann, David Henderson, Hans Lehrach, Marie-Laure Yaspo, Christoph Reinhard, Reinhold Schäfer, Ulrich Keilholz, Christian Regenbrecht, Rudolf Schicho, Peter Fickert, Sigurd F. Lax, Frank Erdmann, Marcel H. Schulz, Alexandra K. Kiemer, Johannes Haybaeck, Sonja M. Kessler
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-14 (2023)
Abstract Aim Chemoresistance is a major cause of treatment failure in colorectal cancer (CRC) therapy. In this study, the impact of the IGF2BP family of RNA-binding proteins on CRC chemoresistance was investigated using in silico, in vitro, and in vi
Externí odkaz:
https://doaj.org/article/8de696616f90444eab4aecca58af009f
Autor:
Eva Gruden, Melanie Kienzl, Dusica Ristic, Oliver Kindler, David Markus Kaspret, Sophie Theresa Schmid, Julia Kargl, Eva Sturm, Alfred D. Doyle, Benjamin L. Wright, Franziska Baumann-Durchschein, Julia Konrad, Andreas Blesl, Hansjörg Schlager, Rudolf Schicho
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionEosinophilic esophagitis (EoE) is a chronic, inflammatory, antigen-driven disease of the esophagus. Tissue EoE pathology has previously been extensively characterized by novel transcriptomics and proteomic platforms, however the majority
Externí odkaz:
https://doaj.org/article/81178be6e1fd4cbeacbd002673c765da
Autor:
Arailym Sarsembayeva, Rudolf Schicho
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Numerous studies in various cancer models have demonstrated that ingredients of cannabis can influence tumor growth through the endocannabinoid system (ECS), a network of molecules (mediators, receptors, transporters, enzymes) that maintains homeosta
Externí odkaz:
https://doaj.org/article/2f0b45e7e18c440a9f4938ca1c6521b3
Autor:
Nejra Cosic-Mujkanovic, Paulina Valadez-Cosmes, Kathrin Maitz, Anna Lueger, Zala N. Mihalic, Marah C. Runtsch, Melanie Kienzl, Michael J. Davies, Christine Y. Chuang, Akos Heinemann, Rudolf Schicho, Gunther Marsche, Julia Kargl
Publikováno v:
Antioxidants, Vol 12, Iss 8, p 1587 (2023)
Myeloperoxidase (MPO) is a neutrophil-derived enzyme that has been recently associated with tumour development. However, the mechanisms by which this enzyme exerts its functions remain unclear. In this study, we investigated whether myeloperoxidase c
Externí odkaz:
https://doaj.org/article/682bfad2e156490f964323c66d5ae8f4
Autor:
Arailym Sarsembayeva, Melanie Kienzl, Eva Gruden, Dusica Ristic, Kathrin Maitz, Paulina Valadez-Cosmes, Ana Santiso, Carina Hasenoehrl, Luka Brcic, Jörg Lindenmann, Julia Kargl, Rudolf Schicho
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
Cannabinoid (CB) receptors (CB1 and CB2) are expressed on cancer cells and their expression influences carcinogenesis in various tumor entities. Cells of the tumor microenvironment (TME) also express CB receptors, however, their role in tumor develop
Externí odkaz:
https://doaj.org/article/8fc695dd4a07458a91b2e4e48bd4b41a
Autor:
Paulina Valadez-Cosmes, Kathrin Maitz, Oliver Kindler, Sofia Raftopoulou, Melanie Kienzl, Ana Santiso, Zala Nikita Mihalic, Luka Brcic, Jörg Lindenmann, Melanie Fediuk, Martin Pichler, Rudolf Schicho, A. McGarry Houghton, Akos Heinemann, Julia Kargl
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Neutrophils have been described as a phenotypically heterogeneous cell type that possess both pro- and anti-tumor properties. Recently, a subset of neutrophils isolated from the peripheral blood mononuclear cell (PBMC) fraction has been described in
Externí odkaz:
https://doaj.org/article/34db15e98bdf4ffb9ebb9e98f6bef13e
Autor:
Gabriel Chalhoub, Stephanie Kolleritsch, Lisa K. Maresch, Ulrike Taschler, Laura Pajed, Anna Tilp, Helgit Eisner, Philipp Rosina, Benedikt Kien, Franz P.W. Radner, Rudolf Schicho, Monika Oberer, Gabriele Schoiswohl, Guenter Haemmerle
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100075- (2021)
Carboxylesterase 2 (CES2/Ces2) proteins exert established roles in (pro)drug metabolism. Recently, human and murine CES2/Ces2c have been discovered as triglyceride (TG) hydrolases implicated in the development of obesity and fatty liver disease. The
Externí odkaz:
https://doaj.org/article/f72aae932f6c49aebeb9e5d4cbae4592
Autor:
Melanie Kienzl, Carina Hasenoehrl, Kathrin Maitz, Arailym Sarsembayeva, Ulrike Taschler, Paulina Valadez-Cosmes, Oliver Kindler, Dusica Ristic, Sofia Raftopoulou, Ana Santiso, Thomas Bärnthaler, Luka Brcic, Lisa Hahnefeld, Robert Gurke, Dominique Thomas, Gerd Geisslinger, Julia Kargl, Rudolf Schicho
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Monoacylglycerol lipase (MGL) expressed in cancer cells influences cancer pathogenesis but the role of MGL in the tumor microenvironment (TME) is less known. Using a syngeneic tumor model with KP cells (KrasLSL-G12D/p53fl/fl; from mouse lung adenocar
Externí odkaz:
https://doaj.org/article/232b65eeccc3450991a17b0f0c509451
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 6, p 3218 (2022)
Neutrophils are immune cells with reported phenotypic and functional plasticity. Tumor-associated neutrophils display many roles during cancer progression. Several tumor microenvironment (TME)-derived factors orchestrate neutrophil release from the b
Externí odkaz:
https://doaj.org/article/2a5d46e587df4121974b5c8553cdc822
Autor:
Melanie Kienzl, Carina Hasenoehrl, Paulina Valadez-Cosmes, Kathrin Maitz, Arailym Sarsembayeva, Eva Sturm, Akos Heinemann, Julia Kargl, Rudolf Schicho
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
In many types of cancer, presence of eosinophils in tumors correlate with an improved disease outcome. In line with this, activated eosinophils have been shown to reduce tumor growth in colorectal cancer (CRC). Interleukin (IL)-33 has recently emerge
Externí odkaz:
https://doaj.org/article/2388d2cea628414ca45b7c278ddf7908