Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Rudolf, Nenutil"'
Autor:
Petr Lapcik, Klara Synkova, Lucia Janacova, Pavla Bouchalova, David Potesil, Rudolf Nenutil, Pavel Bouchal
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-7 (2024)
Abstract Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, and deeper proteome coverage is needed for its molecular characterization. We present comprehensive library of targeted mass spectrometry assays specific f
Externí odkaz:
https://doaj.org/article/2d12a41b2f2b49e78e7f63f0d2362dd3
Autor:
Iva Benesova, Rudolf Nenutil, Adam Urminsky, Erika Lattova, Lukas Uhrik, Peter Grell, Filip Zavadil Kokas, Jana Halamkova, Zbynek Zdrahal, Borivoj Vojtesek, Milos V. Novotny, Lenka Hernychova
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Breast cancer is a highly heterogeneous disease. Its intrinsic subtype classification for diagnosis and choice of therapy traditionally relies on the presence of characteristic receptors. Unfortunately, this classification is often not suffi
Externí odkaz:
https://doaj.org/article/94832c75874a4386884dac9683301066
Autor:
Petr Holub, Heimo Müller, Tomáš Bíl, Luca Pireddu, Markus Plass, Fabian Prasser, Irene Schlünder, Kurt Zatloukal, Rudolf Nenutil, Tomáš Brázdil
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Access to large volumes of so-called whole-slide images—high-resolution scans of complete pathological slides—has become a cornerstone of the development of novel artificial intelligence methods in pathology for diagnostic use, education
Externí odkaz:
https://doaj.org/article/9c9ee166c04045f5a114176b5087ddd5
Autor:
Eva Budinská, Martina Hrivňáková, Tina Catela Ivkovic, Marie Madrzyk, Rudolf Nenutil, Beatrix Bencsiková, Dagmar Al Tukmachi, Michaela Ručková, Lenka Zdražilová Dubská, Ondřej Slabý, Josef Feit, Mihnea-Paul Dragomir, Petra Borilova Linhartova, Sabine Tejpar, Vlad Popovici
Publikováno v:
eLife, Vol 12 (2023)
Heterogeneity of colorectal carcinoma (CRC) represents a major hurdle towards personalized medicine. Efforts based on whole tumor profiling demonstrated that the CRC molecular subtypes were associated with specific tumor morphological patterns repres
Externí odkaz:
https://doaj.org/article/df5a7f3756954a51b6a7bf57f1db34a7
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 8, Iss 2, Pp 129-142 (2022)
Abstract The diagnosis of solid tumors of epithelial origin (carcinomas) represents a major part of the workload in clinical histopathology. Carcinomas consist of malignant epithelial cells arranged in more or less cohesive clusters of variable size
Externí odkaz:
https://doaj.org/article/07a528fcc3c7472b949b5ab932a5a900
Publikováno v:
Pathology and Oncology Research, Vol 28 (2022)
Signal transducer and activator of transcription 3 (Stat3) is responsible for many aspects of normal development and contributes to the development and progression of cancer through regulating epithelial cell identity and cancer stem cells. In breast
Externí odkaz:
https://doaj.org/article/8d7cd23200ef4d5293bbb154d32f90cb
Autor:
Yajing Liu, Marta Nekulova, Rudolf Nenutil, Iva Horakova, M Virginia Appleyard, Karen Murray, Jitka Holcakova, Michaela Galoczova, Philip Quinlan, Lee B Jordan, Colin A Purdie, Borivoj Vojtesek, Alastair M Thompson, Philip J Coates
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 6, Iss 1, Pp 83-93 (2020)
Abstract ΔNp63, also known as p40, regulates stemness of normal mammary gland epithelium and provides stem cell characteristics in basal and HER2‐driven murine breast cancer models. Whilst ΔNp63/p40 is a characteristic feature of normal basal cel
Externí odkaz:
https://doaj.org/article/3cd8cd98aa5044f882f47e3842a4e081
Autor:
Beatrix Bencsikova, Eva Budinska, Iveta Selingerova, Katerina Pilatova, Lenka Fedorova, Kristina Greplova, Rudolf Nenutil, Dalibor Valik, Radka Obermannova, Michael A. Sheard, Lenka Zdrazilova-Dubska
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-9 (2019)
Abstract Background In a prospective study with long-term follow-up, we analyzed circulating T cell subsets in patients with metastatic colorectal cancer (mCRC) in the context of primary tumor sidedness, KRAS status, and clinical outcome. Our primary
Externí odkaz:
https://doaj.org/article/26d0eadb3fd44925b10740e9459f65ab
Autor:
Petr Muller, Philip J. Coates, Rudolf Nenutil, Filip Trcka, Roman Hrstka, Josef Chovanec, Veronika Brychtova, Borivoj Vojtesek
Publikováno v:
Journal of Ovarian Research, Vol 12, Iss 1, Pp 1-7 (2019)
Abstract Background Increased activity of the chaperones Hsp70 and Hsp90 is a common feature of solid tumours. Translocase of the outer mitochondrial membrane 34 (Tomm34) is a cochaperone of both Hsp70 and Hsp90 that was found to be overexpressed in
Externí odkaz:
https://doaj.org/article/d42bc5eeaed94b09aa3eb8911acdc4b8
Autor:
Oldřich Coufal, Tomáš Ostřížek, Petr Krsička, Eva Lžičařová, Rudolf Nenutil, Monika Procházková, Beatrix Bencsiková, Peter Grell, Roman Šefr
Publikováno v:
World Journal of Surgical Oncology, Vol 15, Iss 1, Pp 1-4 (2017)
Abstract Background Breast cancer can be diagnosed easily in most cases. However, occasionally, we are faced with some conditions that can mimic it. These may include inflammations, benign tumors, cysts, hematomas, or, more rarely, focal necrosis. Ca
Externí odkaz:
https://doaj.org/article/3d08397bd8b74d069b5e6b748570d612