Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Rudolf, Laufer"'
Autor:
Nariman Essmat, Anna Rita Galambos, Péter P. Lakatos, Dávid Árpád Karádi, Amir Mohammadzadeh, Sarah Kadhim Abbood, Orsolya Geda, Rudolf Laufer, Kornél Király, Pál Riba, Zoltán S. Zádori, Éva Szökő, Tamás Tábi, Mahmoud Al-Khrasani
Publikováno v:
Pharmaceuticals, Vol 16, Iss 8, p 1115 (2023)
The current treatment of neuropathic pain (NP) is unsatisfactory; therefore, effective novel agents or combination-based analgesic therapies are needed. Herein, oral tolperisone, pregabalin, and duloxetine were tested for their antinociceptive effect
Externí odkaz:
https://doaj.org/article/154a5b30e75747f291e2a5926563b570
Autor:
Péter P. Lakatos, Dávid Árpád Karádi, Anna Rita Galambos, Nariman Essmat, Kornél Király, Rudolf Laufer, Orsolya Geda, Zoltán S. Zádori, Tamás Tábi, Mahmoud Al-Khrasani, Éva Szökő
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9564 (2022)
Current treatment approaches to manage neuropathic pain have a slow onset and their use is largely hampered by side-effects, thus there is a significant need for finding new medications. Tolperisone, a centrally acting muscle relaxant with a favorabl
Externí odkaz:
https://doaj.org/article/0b1611307c9a4634a73251f0b86306b8
Autor:
V. Csomor, Zita Pöstényi, Kornélia Tekes, Rudolf Laufer, Abdu Adem, Huba Kalász, Ernest Adeghate, Syed M. Nurulain
Publikováno v:
Acta Chromatographica. 26:649-656
l-Deprenyl and its major metabolites were subjected to reversed-phase high-performance liquid chromatography (HPLC). The separation was monitored using both ultraviolet (UV) and electrochemical detectors. Ultraviolet absorbance detected l-deprenyl, l
Publikováno v:
Acta Physiologica Hungarica. 101:40-46
Effect of a new acetylcholine-esterase reactivator, K203 as a new potential antidote in organophosphate intoxications was studied on dopamine (DA), homovanillic acid (HVA), serotonin (5-HT) and 5-hydroxyindolacetic acid (5-HIAA) levels in seven brain
Autor:
Rudolf Laufer, Afshan Siddiq, F. Hashemi, Kornélia Tekes, Saeed Tariq, Huba Kalász, Ernest Adeghate
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 13:1389-1397
Nociceptinergic system has become an important target for drug development since the identification of the "orphan", opioid-like-1 receptor and the isolation of its endogenous agonist nociceptin. Involvement of nociceptinergic system has been verifie
Publikováno v:
Analytical and Bioanalytical Chemistry. 397:579-586
Reversed-phase separation of various pyridinium aldoximes requires a certain concentration of ion-pairing agent, as their chemical structures contain two quaternary amines in the pyridinium ring. Adequate mobile phase is scouted on the basis of reten
Autor:
Kamil Kuca, Kornélia Tekes, Ferenc Darvas, Huba Kalász, P. Szegi, Kamil Musilek, Rudolf Laufer
Publikováno v:
Current Organic Chemistry. 14:447-456
Publikováno v:
Acta Chromatographica. 21:399-410
Summary Reversed-phase HPLC has been used to monitor the concentration of the two major Chamomile components rutin and quercetin during rat liver microsomal treatment. The possibility of microsomal oxidative metabolism or stability of these two compo
Autor:
Eva Szoke, Bernadett Benko, Ferenc Darvas, Huba Kalász, Georg Petroianu, P. Szegi, Kornélia Tekes, Rudolf Laufer
Publikováno v:
The Open Medicinal Chemistry Journal
Three major flavonoid chamomile components (quercetin, apigenin-7-O-glucoside and rutin) were subjected to oxidative metabolism by cytochrome P-450 of rat liver microsomal preparations. Changes over time in their respective concentrations were follow
Publikováno v:
Acta Chromatographica. 20:575-584
Summary The pharmacokinetics of K-203, a recently synthesized bis-pyridinium aldoxime, have been investigated by reversed-phase HPLC. The K-203 content of serum samples was monitored by HPLC with ultraviolet absorbance detection at 286 nm. The low co