Structures of heat shock factor trimers bound to DNA

Autor: Na Feng, Han Feng, Sheng Wang, Avinash S. Punekar, Rudolf Ladenstein, Da-Cheng Wang, Qinghua Zhang, Jingjin Ding, Wei Liu

Publikováno v: iScience, Vol 24, Iss 9, Pp 102951- (2021)

Summary: Heat shock factor 1 (HSF1) and 2 (HSF2) play distinct but overlapping regulatory roles in maintaining cellular proteostasis or mediating cell differentiation and development. Upon activation, both HSFs trimerize and bind to heat shock elemen

Externí odkaz: https://doaj.org/article/8a612f7468c442f7a3987769bbc4a9ca

MD simulation of high-resolution X-ray structures reveals post-translational modification dependent conformational changes in HSF-DNA interaction

Autor: Han Feng, Sheng Wang, Ling Guo, Avinash S. Punekar, Rudolf Ladenstein, Da-Cheng Wang, Wei Liu

Publikováno v: Protein & Cell, Vol 7, Iss 12, Pp 916-920 (2016)

Externí odkaz: https://doaj.org/article/c0e3ced3b9794d79abc174ce08a4b894

Second career of a biosynthetic enzyme: Lumazine synthase as a virus-like nanoparticle in vaccine development

Autor: Ekaterina Morgunova, Rudolf Ladenstein

Publikováno v: Biotechnology Reports
Biotechnology Reports, Vol 27, Iss, Pp e00494-(2020)

Highlights • Virus-like nano-particles can be successfully applied in vaccine development. • Scaffolds can be cage-forming highly symmetric biological macromolecules, like lumazine synthase, ferritin or self-assembling nanoparticles created compu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda930dc34796c5299c3681c42515c7f
http://europepmc.org/articles/PMC7369331

123I-mIBG scintigraphy in neuroblastoma: development of a SIOPEN semi-quantitative reporting ,method by an international panel

Autor: Francesco Giammarile, Bo Lambert, Val Lewington, Rita Castellani, Ulrike Poetschger, Rudolf Ladenstein, Anton Staudenherz, Barry L. Shulkin, Z. Bar Sever, T. Lynch, Mario Drobics, Alexander J.B. McEwan

Publikováno v: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
Lewington, V, Lambert, B, Poetschger, U, Sever, Z B, Giammarile, F, McEwan, A J B, Castellani, R, Lynch, T, Shulkin, B, Drobics, M, Staudenherz, A & Ladenstein, R 2017, ' 123 I-mIBG scintigraphy in neuroblastoma : development of a SIOPEN semi-quantitative reporting,method by an international panel ', European Journal of Nuclear Medicine and Molecular Imaging, vol. 44, no. 2, pp. 234-241 . https://doi.org/10.1007/s00259-016-3516-0
European Journal of Nuclear Medicine and Molecular Imaging

Purpose: A robust method is required to standardise objective reporting of diagnostic 123I-mIBG images in neuroblastoma. Prerequisites for an appropriate system are low inter- and intra-observer error and reproducibility across a broad disease spectr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::112babd9ce51ad6830dae8ae45cdabf2
https://doi.org/10.1007/s00259-016-3516-0

Rigidity versus flexibility: the dilemma of understanding protein thermal stability

Autor: Lennart Nilsson, Andrey Karshikoff, Rudolf Ladenstein

Publikováno v: FEBS Journal. 282:3899-3917

The role of fluctuations in protein thermostability has recently received considerable attention. In the current literature a dualistic picture can be found: thermostability seems to be associated with enhanced rigidity of the protein scaffold in par

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021270a2c2ed0a3353581b0678b3cd89
https://doi.org/10.1111/febs.13343