Specific inhibition of the JNK pathway promotes locomotor recovery and neuroprotection after mouse spinal cord injury

Autor: Mariaelena Repici, Xiaoru Chen, Marie-Pierre Morel, Mohamed Doulazmi, Alessandra Sclip, Vidjeacoumary Cannaya, Pietro Veglianese, Rudolf Kraftsik, Jean Mariani, Tiziana Borsello, Isabelle Dusart

Publikováno v: Neurobiology of Disease, Vol 46, Iss 3, Pp 710-721 (2012)

Limiting the development of secondary damage represents one of the major goals of neuroprotective therapies after spinal cord injury. Here, we demonstrate that specific JNK inhibition via a single intraperitoneal injection of the cell permeable pepti

Externí odkaz: https://doaj.org/article/96ff9424bcf04b198c9855badc70d2ae

Pre-existing astrocytes form functional perisynaptic processes on neurons generated in the adult hippocampus

Autor: Valentin Schmutz, Nicolas Toni, Mari A. Virtanen, Lucas A. Mongiat, Jan Armida, Matteo Bergami, Laszlo Vutskits, Marine Krzisch, Fred H. Gage, Alejandro F. Schinder, Jacqueline Kocher-Braissant, Silvio Gabriel Temprana, Karl-Klaus Conzelmann, Rudolf Kraftsik

Publikováno v: Brain Structure & Function
Brain structure & function
Brain Structure and Function, vol. 220, no. 4, pp. 2027-2042
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Brain Structure and Function, Vol. 220, No 4 (2015) pp. 2027-2042

The adult dentate gyrus produces new neurons that morphologically and functionally integrate into the hippocampal network. In the adult brain, most excitatory synapses are ensheathed by astrocytic perisynaptic processes that regulate synaptic structu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f4ce4747eb262a82ec34c49ed41eaac
http://doc.rero.ch/record/331327/files/429_2014_Article_768.pdf

Neurosphere-derived cells exert a neuroprotective action by changing the ischemic microenvironment.

Autor: Carmen Capone, Simona Frigerio, Stefano Fumagalli, Maurizio Gelati, Maria-Cristina Principato, Claudio Storini, Mery Montinaro, Rudolf Kraftsik, Marco De Curtis, Eugenio Parati, Maria-Grazia De Simoni

Publikováno v: PLoS ONE, Vol 2, Iss 4, p e373 (2007)

BACKGROUND: Neurosphere-derived cells (NC), containing neural stem cells, various progenitors and more differentiated cells, were obtained from newborn C57/BL6 mice and infused in a murine model of focal ischemia with reperfusion to investigate if: 1

Externí odkaz: https://doaj.org/article/caf4c4fddbb446068f6c10892d0d36f2

Perineuronal nets protect fast-spiking interneurons against oxidative stress

Autor: Takao K. Hensch, Hirofumi Morishita, Michel Cuenod, Pascal Steullet, Rudolf Kraftsik, Jan-Harry Cabungcal, Kim Q. Do

Publikováno v: Proceedings of the National Academy of Sciences USA

A hallmark of schizophrenia pathophysiology is the dysfunction of cortical inhibitory GABA neurons expressing parvalbumin, which are essential for coordinating neuronal synchrony during various sensory and cognitive tasks. The high metabolic requirem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::987ac0923ea2f84640ef87725e3fbd83
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670388/pdf/pnas.201300454.pdf

Intracortical connectivity of layer VI pyramidal neurons in the somatosensory cortex of normal and barrelless mice

Autor: Rudolf Kraftsik, Egbert Welker, Fabien Pichon, Irina Nikonenko

Publikováno v: European Journal of Neuroscience. 35:855-869

In mice, barrels in layer IV of the somatosensory cortex correspond to the columnar representations of whisker follicles. In barrelless (BRL) mice, barrels are absent, but functionally, a columnar organization persists. Previously we characterized th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b22d445e5c29608f911d2c29451ec616
https://doi.org/10.1111/j.1460-9568.2012.08011.x