Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Rudolf, Fuchshofer"'
Autor:
Sabrina Reinehr, Julien Wulf, Janine Theile, Kim K. Schulte, Marcus Peters, Rudolf Fuchshofer, H. Burkhard Dick, Stephanie C. Joachim
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundThe neurodegenerative processes leading to glaucoma are complex. In addition to elevated intraocular pressure (IOP), an involvement of immunological mechanisms is most likely. In the new multifactorial glaucoma model, a combination of high
Externí odkaz:
https://doaj.org/article/799de27d974245298b0db025ebd09068
Autor:
Andrea E. Dillinger, Sabrina Kuespert, Amin A. Seleem, Jakob Neuendorf, Magdalena Schneider, Rudolf Fuchshofer
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
TGF-β2 is the predominant TGF-β isoform within the eye. One function of TGF-β2 is to provide the eye with immune protection against intraocular inflammation. The beneficial function of TGF-β2 within the eye must be under tight control of a networ
Externí odkaz:
https://doaj.org/article/0194ad2ada9643be9734e61da67451ca
Autor:
Sabrina Reinehr, Renée M. Girbig, Kim K. Schulte, Janine Theile, M. Ali Asaad, Rudolf Fuchshofer, H. Burkhard Dick, Stephanie C. Joachim
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
IntroductionGlaucoma is a complex, multifactorial neurodegenerative disease, which can lead to blindness if left untreated. It seems that, among others, immune processes, elevated intraocular pressure (IOP), or a combination of these factors are resp
Externí odkaz:
https://doaj.org/article/3274535e81f146b081e9c71a21a62812
Autor:
Andrea E. Dillinger, Gregor R. Weber, Matthias Mayer, Magdalena Schneider, Corinna Göppner, Andreas Ohlmann, Mikhail Shamonin, Gareth J. Monkman, Rudolf Fuchshofer
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
In primary open-angle glaucoma (POAG), a neurodegenerative disease of the optic nerve (ON) and leading cause of blindness, the optic nerve head (ONH) undergoes marked structural extracellular matrix (ECM) changes, which contribute to its permanent de
Externí odkaz:
https://doaj.org/article/51eaaa84df79459b99db71fbc9e113e5
Autor:
Sabrina Reinehr, Johanna D. Doerner, Ana M. Mueller-Buehl, Dennis Koch, Rudolf Fuchshofer, H. Burkhard Dick, Stephanie C. Joachim
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Glaucoma is a complex neurodegenerative disease leading to a loss of retinal ganglion cells (RGCs) and optic nerve axons. An activation of the complement system seems to contribute to cell loss in this disease. Hence, we investigated a possible initi
Externí odkaz:
https://doaj.org/article/dcae5067634d4f8a89f80d14e5167502
Autor:
Raphael Mietzner, Ramona Pawlak, Ernst R. Tamm, Achim Goepferich, Rudolf Fuchshofer, Miriam Breunig
Publikováno v:
Pharmaceuticals, Vol 15, Iss 1, p 18 (2021)
A root cause for the development and progression of primary open-angle glaucoma might be the loss of the Schlemm’s canal (SC) cell function due to an impaired Angiopoietin-1 (Angpt-1)/Tie2 signaling. Current therapeutic options fail to restore the
Externí odkaz:
https://doaj.org/article/13ba8a624b6942ba8a42e5fce7a9f52b
Autor:
Tobias Sonntag, Franziska Froemel, W. Daniel Stamer, Andreas Ohlmann, Rudolf Fuchshofer, Miriam Breunig
Publikováno v:
Pharmaceutics, Vol 13, Iss 6, p 901 (2021)
In glaucoma therapy, nanoparticles (NPs) are a favorable tool for delivering drugs to the outflow tissues of the anterior chamber of the eye where disease development and progression take place. In this context, a prerequisite is an efficient enrichm
Externí odkaz:
https://doaj.org/article/e109bff045a348efbff487a22e56e1fd
Autor:
Raphael Mietzner, Christian Kade, Franziska Froemel, Diana Pauly, W. Daniel Stamer, Andreas Ohlmann, Joachim Wegener, Rudolf Fuchshofer, Miriam Breunig
Publikováno v:
Pharmaceutics, Vol 12, Iss 8, p 706 (2020)
Rho-associated protein kinase (ROCK) inhibitors allow for causative glaucoma therapy. Unfortunately, topically applied ROCK inhibitors suffer from high incidence of hyperemia and low intraocular bioavailability. Therefore, we propose the use of poly
Externí odkaz:
https://doaj.org/article/64db04ae5498400f92e112cc3cc8bf40
Autor:
Stefan Kassumeh, Stephanie Leopold, Rudolf Fuchshofer, Carina N. Thomas, Siegfried G. Priglinger, Ernst R. Tamm, Andreas Ohlmann
Publikováno v:
Cells, Vol 9, Iss 2, p 277 (2020)
Purpose: To investigate whether and how leukemia inhibitory factor (Lif) is involved in mediating the neuroprotective effects of Norrin on retinal ganglion cells (RGC) following excitotoxic damage. Norrin is a secreted protein that protects RGC from
Externí odkaz:
https://doaj.org/article/1aebfdf3323b41a8bdf1ad03b54b8738
Autor:
Magdalena Schneider, Rudolf Fuchshofer, Andreas Ohlmann, Renato V. Iozzo, Andrea E. Dillinger
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 14
International Journal of Molecular Sciences, Vol 22, Iss 7660, p 7660 (2021)
Volume 22
Issue 14
International Journal of Molecular Sciences, Vol 22, Iss 7660, p 7660 (2021)
During the pathogenesis of glaucoma, optic nerve (ON) axons become continuously damaged at the optic nerve head (ONH). This often is associated with reactive astrocytes and increased transforming growth factor (TGF-β) 2 levels. In this study we test
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acfb70885d9aa587117ed35a7b0a9983