Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Rudo Kieft"'
Autor:
Rudo Kieft, Yang Zhang, Alexandre P Marand, Jose Dagoberto Moran, Robert Bridger, Lance Wells, Robert J Schmitz, Robert Sabatini
Publikováno v:
PLoS Genetics, Vol 16, Iss 2, p e1008390 (2020)
Base J, β-D-glucosyl-hydroxymethyluracil, is a modification of thymine DNA base involved in RNA Polymerase (Pol) II transcription termination in kinetoplastid protozoa. Little is understood regarding how specific thymine residues are targeted for J-
Externí odkaz:
https://doaj.org/article/38f4685d7d8849febf24f65cfe34bdb6
Autor:
Paul Capewell, Caroline Clucas, Eric DeJesus, Rudo Kieft, Stephen Hajduk, Nicola Veitch, Pieter C Steketee, Anneli Cooper, William Weir, Annette MacLeod
Publikováno v:
PLoS Pathogens, Vol 9, Iss 10, p e1003686 (2013)
Trypanosoma brucei gambiense causes 97% of all cases of African sleeping sickness, a fatal disease of sub-Saharan Africa. Most species of trypanosome, such as T. b. brucei, are unable to infect humans due to the trypanolytic serum protein apolipoprot
Externí odkaz:
https://doaj.org/article/ddf283bedbe2423f9c8f2ebbe2e5b9aa
Publikováno v:
Nucleic Acids Research.
The genomes of kinetoplastids are organized into polycistronic transcription units that are flanked by a modified DNA base (base J, beta-D-glucosyl-hydroxymethyluracil). Previous work established a role of base J in promoting RNA polymerase II (Pol I
Autor:
Robert Bridger, Robert J. Schmitz, Yang Zhang, Alexandre P. Marand, Lance Wells, Jose Dagoberto Moran, Robert Sabatini, Rudo Kieft
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 16, Iss 2, p e1008390 (2020)
PLoS Genetics, 16(2):e1008390
PLoS Genetics, Vol 16, Iss 2, p e1008390 (2020)
PLoS Genetics, 16(2):e1008390
Base J, β-D-glucosyl-hydroxymethyluracil, is a modification of thymine DNA base involved in RNA Polymerase (Pol) II transcription termination in kinetoplastid protozoa. Little is understood regarding how specific thymine residues are targeted for J-
Autor:
Igor C. Almeida, Anthony J. Szempruch, John M. Harrington, Ernesto S. Nakayasu, Allison C. Becker, William J. Martin, Anzio Gartrell, Lauren Dennison, Rudo Kieft, Stephen L. Hajduk, Steven E. Sykes
Publikováno v:
Cell. 164:246-257
Intercellular communication between parasites and with host cells provides mechanisms for parasite development, immune evasion, and disease pathology. Bloodstream African trypanosomes produce membranous nanotubes that originate from the flagellar mem
Publikováno v:
Biology methods and protocols
Recently, 5-hydroxymethyluracil (5hmU) was identified in mammalian genomic DNA as an oxidative product of thymine by the ten-eleven translocation (TET) proteins. While the biological role of this modification remains unclear, identifying its genomic
Publikováno v:
Nature reviews. Microbiology. 14(11)
Parasitic unicellular eukaryotes use extracellular vesicles (EVs) as vehicles for intercellular communication and host manipulation. By using various mechanisms to generate EVs and by transferring a wide range of molecules through EVs, pathogenic pro
Autor:
D. B. Mark Welch, Wilfred Fon Mbacham, Vpk Titanji, Stephen L. Hajduk, Andrew G. McArthur, Tedom, V Penlap, Rudo Kieft
Publikováno v:
Asian Pacific Journal of Tropical Disease, Vol 2, Iss 5, Pp 342-347 (2012)
Objective To understand the spread of drug resistance and identifying diagnostic probes among the local tuberculosis (TB) strains in order to design rational control tools for tuberculosis controls. Methods TA cloning and sequencing were used to char
Autor:
Stephen L. Hajduk, Whitney Bullard, Paul Capewell, Rudo Kieft, Annette MacLeod, Nicola Veitch
Publikováno v:
Virulence
The haptoglobin-hemoglobin receptor (HpHbR) of African trypanosomes plays a critical role in human innate immunity against these parasites. Localized to the flagellar pocket of the veterinary pathogen Trypanosoma brucei brucei this receptor binds Try
Autor:
Rudo Kieft, Laura Cliffe, Robert Sabatini, Marion Marshall, Timothy Southern, Shanda R. Birkeland, Kate Sweeney
Publikováno v:
Nucleic Acids Research
Genomic DNA of African trypanosomes contains a hypermodified thymidine residue termed base J (beta-d-glucosyl-HOMedU). This modified base is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic