Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Rudiyanto, Gunawan"'
Autor:
Georgios Tseropoulos, Pihu Mehrotra, Ashis Kumer Podder, Emma Wilson, Yali Zhang, Jianmin Wang, Alison Koontz, Nan Papili Gao, Rudiyanto Gunawan, Song Liu, Laura M. Feltri, Marianne E. Bronner, Stelios T. Andreadis
Publikováno v:
Advanced Science, Vol 11, Iss 33, Pp n/a-n/a (2024)
Abstract Neural Crest cells (NC) are a multipotent cell population that give rise to a multitude of cell types including Schwann cells (SC) in the peripheral nervous system (PNS). Immature SC interact with neuronal axons via the neuregulin 1 (NRG1) l
Externí odkaz:
https://doaj.org/article/42ef817889b942149013f1f69c71619c
Publikováno v:
F1000Research, Vol 12 (2023)
Background: Single-cell studies have demonstrated the presence of significant cell-to-cell heterogeneity in gene expression. Whether such heterogeneity is only a bystander or has a functional role in the cell differentiation process is still hotly de
Externí odkaz:
https://doaj.org/article/502a6245c2fb4bffb5ab35093c4a27c8
Autor:
Romuald Parmentier, Laëtitia Racine, Alice Moussy, Sophie Chantalat, Ravi Sudharshan, Nan Papili Gao, Daniel Stockholm, Guillaume Corre, Geneviève Fourel, Jean-François Deleuze, Rudiyanto Gunawan, Andras Paldi
Publikováno v:
PLoS Biology, Vol 20, Iss 10, p e3001849 (2022)
When human cord blood-derived CD34+ cells are induced to differentiate, they undergo rapid and dynamic morphological and molecular transformations that are critical for fate commitment. In particular, the cells pass through a transitory phase known a
Externí odkaz:
https://doaj.org/article/1bf12cb102034345ac6078e5b899788a
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 1712-1724 (2021)
Glycosylation is a common posttranslational modification, and glycan biosynthesis is regulated by a set of glycogenes. The role of transcription factors (TFs) in regulating the glycogenes and related glycosylation pathways is largely unknown. In this
Externí odkaz:
https://doaj.org/article/1c56f9f0067d441eb6e5e04a676fb922
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-19 (2021)
Abstract Background Knowledge on the molecular targets of diseases and drugs is crucial for elucidating disease pathogenesis and mechanism of action of drugs, and for driving drug discovery and treatment formulation. In this regard, high-throughput g
Externí odkaz:
https://doaj.org/article/70caedfd5705442ca248669ca449ce82
Autor:
Sudharshan Ravi, Rudiyanto Gunawan
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 11, p e1009589 (2021)
Genome-scale metabolic models (GEMs) provide a powerful framework for simulating the entire set of biochemical reactions in a cell using a constraint-based modeling strategy called flux balance analysis (FBA). FBA relies on an assumed metabolic objec
Externí odkaz:
https://doaj.org/article/ae273aeebba34f3db087b274601b0e01
Publikováno v:
iScience, Vol 24, Iss 3, Pp 102138- (2021)
Summary: Broad evidence in the literature supports double-strand breaks (DSBs) as initiators of mitochondrial DNA (mtDNA) deletion mutations. While DNA misalignment during DSB repair is commonly proposed as the mechanism by which DSBs cause deletion
Externí odkaz:
https://doaj.org/article/bd7b4659737640a7abdaa97799015f18
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
We present Clustering and Lineage Inference in Single-Cell Transcriptional Analysis (CALISTA), a numerically efficient and highly scalable toolbox for an end-to-end analysis of single-cell transcriptomic profiles. CALISTA includes four essential sing
Externí odkaz:
https://doaj.org/article/9e6a73c0dc074040808113b4e51414d2
Autor:
Saber Meamardoost, Mahasweta Bhattacharya, Eun Jung Hwang, Takaki Komiyama, Claudia Mewes, Linbing Wang, Ying Zhang, Rudiyanto Gunawan
Publikováno v:
Brain Sciences, Vol 11, Iss 12, p 1556 (2021)
The inference of neuronal connectome from large-scale neuronal activity recordings, such as two-photon Calcium imaging, represents an active area of research in computational neuroscience. In this work, we developed FARCI (Fast and Robust Connectome
Externí odkaz:
https://doaj.org/article/f83d4ad759744f91ae75f2162452286f
Autor:
Emelyne Teo, Sudharshan Ravi, Diogo Barardo, Hyung-Seok Kim, Sheng Fong, Amaury Cazenave-Gassiot, Tsze Yin Tan, Jianhong Ching, Jean-Paul Kovalik, Markus R Wenk, Rudiyanto Gunawan, Philip K Moore, Barry Halliwell, Nicholas Tolwinski, Jan Gruber
Publikováno v:
eLife, Vol 8 (2019)
Alzheimer’s disease (AD) is the most common neurodegenerative disease affecting the elderly worldwide. Mitochondrial dysfunction has been proposed as a key event in the etiology of AD. We have previously modeled amyloid-beta (Aβ)-induced mitochond
Externí odkaz:
https://doaj.org/article/eb3eb4a1028f48789394b89e79678ebd