Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Rudiger D. Haugwitz"'
Autor:
Robert L. Geahlen, Jurjus Jurayj, Mark Cushman, Asit K. Chakraborti, Pennamuthiriar Chinnasamy, Rudiger D. Haugwitz
Publikováno v:
International Journal of Peptide and Protein Research. 36:538-543
An asymmetric synthesis of [beta-(4-pyridyl-1-oxide)-L-alanine4]-angiotensin I (1a), which is a potential suicide substrate (mechanism-based inhibitor) for protein-tyrosine kinases, has been performed. Deprotonation of 6 with n-butyllithium in THF ga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b5fb42bb9f53532dc54a91dfe76ea2d
https://doi.org/10.1111/j.1399-3011.1990.tb00993.x
https://doi.org/10.1111/j.1399-3011.1990.tb00993.x
Autor:
Jeffrey A. Vroman, Rudiger D. Haugwitz, Mark Cushman, Melinda Hollingshead, Ankush B. Argade, Rajesh Devraj
Publikováno v:
Journal of Medicinal Chemistry. 41:3337-3346
The addition of a variety of thiols to the alpha,beta-unsaturated lactone functionality present in brefeldin A has been carried out, and the resulting sulfides have been oxidized to the corresponding sulfoxides. These sulfoxides have the potential to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::994ae00b8fe016d0c60725f682ed299c
https://doi.org/10.1021/jm970746g
https://doi.org/10.1021/jm970746g
Autor:
Ankush B. Argade, Mark Cushman, John F. Kozlowski, and Phillip E. Fanwick, Rajesh Devraj, Rudiger D. Haugwitz
Publikováno v:
The Journal of Organic Chemistry. 63:273-278
The Michael addition of thiols to brefeldin A occurs with high diastereoselectivity, affording ratios of major to minor diastereomers of at least 30:1. On the basis of the X-ray structure of a crystalline dibenzoyl derivative, the major diastereomers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0f95add5c88728b3fe014a170b55559
https://doi.org/10.1021/jo971292y
https://doi.org/10.1021/jo971292y
Autor:
Mark Cushman, John F. Barrett, Rudiger D. Haugwitz, Kenneth D. Paull, Ravi K. Varma, Jurjus Jurayj
Publikováno v:
Journal of Medicinal Chemistry. 37:2190-2197
9-Methoxy-2-methylellipticinium acetate (6), along with the 9-methyl and 9-chloro derivatives (7, and 8, respectively) have shown remarkable selectivities in vitro against the NCI human CNS cancer subpanel. In order to target these types of compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cabea709a5cc1893e206d476140b70c
https://doi.org/10.1021/jm00040a011
https://doi.org/10.1021/jm00040a011
Autor:
Kenneth D. Paull, John F. Barrett, Jurjus Jurayj, Ravi K. Varma, Mark Cushman, Rudiger D. Haugwitz
Publikováno v:
ChemInform. 25
9-Methoxy-2-methylellipticinium acetate (6), along with the 9-methyl and 9-chloro derivatives (7, and 8, respectively) have shown remarkable selectivities in vitro against the NCI human CNS cancer subpanel. In order to target these types of compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af4e4f2a21502cd8fe426d42f61fe8c7
https://doi.org/10.1002/chin.199448143
https://doi.org/10.1002/chin.199448143
Autor:
John F. Kozlowski, Phillip E. Fanwick, Rajesh Devraj, Ankush B. Argade, Rudiger D. Haugwitz, Mark Cushman
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b633e6ae2f2121ffb938137d6c5bccc5
https://doi.org/10.1002/chin.199823230
https://doi.org/10.1002/chin.199823230
Publikováno v:
Biochemical and Biophysical Research Communications. 187:1409-1417
A simple synthesis of the sulfonated azo dye Quinobene ( 3 ) and its derivatives, as well as the results of their evaluation in anti-HIV screening have been described. Thus, reacting the diazonium salt of 4,4′-diaminostilbene-2,2′-disulfonic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::578ccf3711101cf4be7151a90abd699c
https://doi.org/10.1016/0006-291x(92)90459-x
https://doi.org/10.1016/0006-291x(92)90459-x
Publikováno v:
Journal of medicinal chemistry. 38(17)
The potential therapeutic application of the naturally occurring, cytotoxic pseudoguaianolide sesquiterpene lactone ambrosin is limited by its aqueous insolubility. A number of water-soluble ambrosin derivatives have therefore been prepared for poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb30d285b8b7483d7e6741989ace6838
https://pubmed.ncbi.nlm.nih.gov/7650694
https://pubmed.ncbi.nlm.nih.gov/7650694
Autor:
B. V. Maurer, Rudiger D. Haugwitz, Larry R. Cruthers, J. Szanto, G. A. Jacobs, R. G. Angel, V. L. Narayanan
Publikováno v:
Journal of Medicinal Chemistry. 25:969-974
The synthesis and antiparasitic properties of 22 isothiocyanato-2-pyridinylbenzoxazoles and benzothiazoles are described; the preparation and anthelmintic activities of 14 isothiocyanato-2-thienyl-, -furyl-, and -pyrrolylbenzoxazoles are outlined. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b94e6e786da23d2c9fac3ac4523ce3
https://doi.org/10.1021/jm00350a017
https://doi.org/10.1021/jm00350a017
Autor:
Ronald S. Michalak, David R. Myers, Rudiger D. Haugwitz, Prabhakar A. Risbood, Venkatachala L. Narayanan, Jack L. Parsons
Publikováno v:
Tetrahedron Letters. 30:4783-4786
Irisquinone 1 has been synthesized for the first time to investigate its use as a potential radiosensitizer. The key step in its synthesis involves the regioselective lithiation of a phenol ether. The cis-double bond has been confirmed via 1H NMR spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04efdcc29aa8d005967716e325205482
https://doi.org/10.1016/s0040-4039(01)80507-4
https://doi.org/10.1016/s0040-4039(01)80507-4