Zobrazeno 1 - 10
of 539
pro vyhledávání: '"Rudi BEYAERT"'
Autor:
Femke Van Gaever, Fleur Mingneau, Sam Vanherle, Yasmine Driege, Mira Haegman, Elien Van Wonterghem, Junhua Xie, Roosmarijn E. Vandenbroucke, Jerome J. A. Hendriks, Rudi Beyaert, Jens Staal
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionOver the past few decades, there has been a sudden rise in the incidence of Multiple Sclerosis (MS) in Western countries. However, current treatments often show limited efficacy in certain patients and are associated with adverse effects,
Externí odkaz:
https://doaj.org/article/c1abff27166741e5a0987d513d85e488
Autor:
Tineke Vanderhaeghen, Steven Timmermans, Melanie Eggermont, Deepika Watts, Jolien Vandewalle, Charlotte Wallaeys, Louise Nuyttens, Joyca De Temmerman, Tino Hochepied, Sylviane Dewaele, Joke Vanden Berghe, Niek Sanders, Ben Wielockx, Rudi Beyaert, Claude Libert
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionPolymicrobial sepsis causes acute anorexia (loss of appetite), leading to lipolysis in white adipose tissue and proteolysis in muscle, and thus release of free fatty acids (FFAs), glycerol and gluconeogenic amino acids. Since hepatic pero
Externí odkaz:
https://doaj.org/article/d4cf3b606e8c4e34ae118f7e43e47016
Exploring Species-Specificity in TLR4/MD-2 Inhibition with Amphiphilic Lipid A Mimicking Glycolipids
Autor:
Alessio Borio, Aurora Holgado, Christina Passegger, Herbert Strobl, Rudi Beyaert, Holger Heine, Alla Zamyatina
Publikováno v:
Molecules, Vol 28, Iss 16, p 5948 (2023)
The Toll-like receptor 4 (TLR4)/myeloid differentiation factor 2 (MD-2) complex is a key receptor of the innate immune system and a major driver of inflammation that is responsible for the multifaceted defense response to Gram-negative infections. Ho
Externí odkaz:
https://doaj.org/article/ffa7754d76574592928f1f2685b16bcb
Autor:
Jolien Souffriau, Steven Timmermans, Tineke Vanderhaeghen, Charlotte Wallaeys, Kelly Van Looveren, Lindsy Aelbrecht, Sylviane Dewaele, Jolien Vandewalle, Evy Goossens, Serge Verbanck, Filip Boyen, Melanie Eggermont, Lindsey De Commer, Riet De Rycke, Michiel De Bruyne, Raul Tito, Marlies Ballegeer, Sofie Vandevyver, Tiago Velho, Luis Ferreira Moita, Tino Hochepied, Karolien De Bosscher, Jeroen Raes, Filip Van Immerseel, Rudi Beyaert, Claude Libert
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 10, Pp 1-21 (2020)
Abstract The cytokine TNF drives inflammatory diseases, e.g., Crohn's disease. In a mouse model of TNF‐induced systemic inflammatory response syndrome (SIRS), severe impact on intestinal epithelial cells (IECs) is observed. Zinc confers complete pr
Externí odkaz:
https://doaj.org/article/3e993b5bbeaf4e78b2bc46c529806814
Publikováno v:
BioTechniques, Vol 66, Iss 6, Pp 254-259 (2019)
Minimal plasmids play an essential role in many intermediate steps in molecular biology. For example, they can be used to assemble building blocks in synthetic biology or be used as intermediate cloning plasmids that are ideal for PCR-based mutagenes
Externí odkaz:
https://doaj.org/article/f0b035d0a87c4661b60a17fc87d6f317
Autor:
Domien Vanneste, Jens Staal, Mira Haegman, Yasmine Driege, Marieke Carels, Elien Van Nuffel, Pieter De Bleser, Yvan Saeys, Rudi Beyaert, Inna S. Afonina
Publikováno v:
Biomedicines, Vol 10, Iss 8, p 2008 (2022)
Prostate cancer (PCa) is one of the most common cancer types in men and represents an increasing global problem due to the modern Western lifestyle. The signalling adapter protein CARD14 is specifically expressed in epithelial cells, where it has bee
Externí odkaz:
https://doaj.org/article/f78b7b27b5104564903b8efdc49a5593
Autor:
Lise Van Wyngene, Tineke Vanderhaeghen, Ioanna Petta, Steven Timmermans, Katrien Corbeels, Bart Van der Schueren, Jolien Vandewalle, Kelly Van Looveren, Charlotte Wallaeys, Melanie Eggermont, Sylviane Dewaele, Leen Catrysse, Geert van Loo, Rudi Beyaert, Roman Vangoitsenhoven, Toshinori Nakayama, Jan Tavernier, Karolien De Bosscher, Claude Libert
Publikováno v:
iScience, Vol 24, Iss 7, Pp 102790- (2021)
Summary: The hypothalamic-pituitary-adrenal (HPA) axis forms a complex neuroendocrine system that regulates the body’s response to stress such as starvation. In contrast with the glucocorticoid receptor (GR), Zinc finger and BTB domain containing 3
Externí odkaz:
https://doaj.org/article/3a3b104cdfd748ce878d5705d4550412
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Glucocorticoid-induced (GC) and hypoxia-induced transcriptional responses play an important role in tissue homeostasis and in the regulation of cellular responses to stress and inflammation. Evidence exists that there is an important crosstalk betwee
Externí odkaz:
https://doaj.org/article/f752843e698d49ab9ff095819aaeafd6
Autor:
Holger Heine, Florian Adanitsch, Tina Tinkara Peternelj, Mira Haegman, Christoph Kasper, Simon Ittig, Rudi Beyaert, Roman Jerala, Alla Zamyatina
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Pro-inflammatory signaling mediated by Toll-like receptor 4 (TLR4)/myeloid differentiation-2 (MD-2) complex plays a crucial role in the instantaneous protection against infectious challenge and largely contributes to recovery from Gram-negative infec
Externí odkaz:
https://doaj.org/article/e0c13eab19ea4893bc449d8224545bc4
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100351- (2021)
Summary: T cells play a key role in adaptive immunity. Defects in specific T cell receptors or signaling proteins can alter their frequency and activation status, which may be associated with immune disease or cancer. Monitoring of T cell frequency a
Externí odkaz:
https://doaj.org/article/e5c4ef09bdbc48fda305dc5c1f6bccc8