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Akademický článek
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Autor:
Le Pichon, CE, Meilandt, WJ, Dominguez, S, Solanoy, H, Lin, H, Ngu, H, Gogineni, A, Ghosh, AS, Jiang, Z, Lee, S-H, Maloney, J, Gandham, VD, Pozniak, CD, Wang, B, Lee, S, Siu, M, Patel, S, Modrusan, Z, Liu, X, Rudhard, Y, Baca, M, Gustafson, A, Kaminker, J, Carano, RAD, Huang, EJ, Foreman, O, Weimer, R, Scearce-Levie, K, Lewcock, JW, Sease, Neurodegenerative
Publikováno v:
Le Pichon, CE; Meilandt, WJ; Dominguez, S; Solanoy, H; Lin, H; Ngu, H; et al.(2017). Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease. SCIENCE TRANSLATIONAL MEDICINE, 9(403). doi: 10.1126/scitranslmed.aag0394. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/1481v5tb
Hallmarks of chronic neurodegenerative disease include progressive synaptic loss and neuronal cell death, yet the cellular pathways that underlie these processes remain largely undefined. We provide evidence that dual leucine zipper kinase (DLK) is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::ee82a5ec36d230fae12b7afd234dd385
http://www.escholarship.org/uc/item/1481v5tb
http://www.escholarship.org/uc/item/1481v5tb
Autor:
Pfeffer, C.K., Stein, V., Keating, D.J., Maier, H., Rinke, I., Rudhard, Y., Hentschke, M., Rune, G.M., Jentsch, T.J., Huebner, C.A.
A high intracellular chloride concentration in immature neurons leads to a depolarizing action of GABA that is thought to shape the developing neuronal network. We show that GABA-triggered depolarization and Ca2+ transients were attenuated in mice de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=mdc______med::67e6df597766c2bda15fb313649c94ef
http://edoc.mdc-berlin.de/9976/1/9976oa.pdf
http://edoc.mdc-berlin.de/9976/1/9976oa.pdf
Autor:
Rust, M.B., Alper, S.L., Rudhard, Y., Shmukler, B.E., Vicente, R., Brugnara, C., Trudel, M., Jentsch, T.J., Huebner, C.A.
K-Cl cotransport activity in rbc is a major determinant of rbc volume and density. Pathologic activation of erythroid K-Cl cotransport activity in sickle cell disease contributes to rbc dehydration and cell sickling. To address the roles of individua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=mdc______med::7df61e7732e8551057c7d9eaedb82d3e
http://edoc.mdc-berlin.de/8836/1/8836oa.pdf
http://edoc.mdc-berlin.de/8836/1/8836oa.pdf