Zobrazeno 1 - 10 of 319 pro vyhledávání: '"Rudd CE"'
1
Small molecule inhibition of PD-1 transcription is an effective alternative to antibody blockade in cancer therapy
Autor: Taylor, A, Rothstein, D, Rudd, CE
The impact of PD-1 immune checkpoint therapy prompts exploration of other strategies to downregulate PD-1 for cancer therapy. We previously showed that the serine/threonine kinase, glycogen synthase kinase GSK-3α/β, is a central regulator of PD-1 t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::3e45f0b892de37fcf108c53f823e980b
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2
Glycogen synthase kinase 3 (GSK-3) inactivation compensates for the lack of CD28 in the priming of CD8+ cytotoxic T-cells: implications for anti-PD-1 immunotherapy
Autor: Taylor, A, Rudd, CE
The rescue of exhausted CD8+ cytolytic T-cells (CTLs) by anti-PD-1 blockade has been found to require CD28 expression. At the same time, we have shown that the inactivation of the serine/threonine kinase GSK‐3α/β with small interfering RNAs (siRN
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::f5f95b23bb37a8a0e42913b10ea6da59
https://eprints.whiterose.ac.uk/124059/7/fimmu-08-01653.pdf
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3
LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation
Autor: Raab, M, Lu, Y, Kohler, K, Smith, X, Strebhardt, K, Rudd, CE
Publikováno v: Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Lymphocyte function-associated antigen 1 (LFA-1) affinity and avidity changes have been assumed to mediate adhesion to intercellular adhesion molecule-1 for T-cell conjugation to dendritic cells (DC). Although the T-cell receptor (TCR) and LFA-1 can
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efeaf31a92483d43e73235cd0ad5d90d
http://europepmc.org/articles/PMC5510181
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4
Activated Cdc42-associated kinase 1 (ACK1) binds the sterile α motif (SAM) domain of the adaptor SLP-76 and phosphorylates proximal tyrosines
Autor: Thaker, YR, Recino, A, Raab, M, Jabeen, A, Wallberg, M, Fernandez, N, Rudd, CE
The adaptor protein Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76) plays a crucial role in T cell activation by linking antigen receptor (T cell receptor, TCR) signals to downstream pathways. At its N terminus, SLP-76 ha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2c0aff33bbc4d502a8a0d322cf418bf7
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/44266
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5
Costimulation of IL-2 production through CD28 is dependent on the size of its ligand
Autor: Lim, HS, Cordoba, SP, Dushek, O, Goyette, J, Taylor, A, Rudd, CE, van der Merwe, PA
Optimal T cell activation typically requires engagement of both the TCR and costimulatory receptors, such as CD28. Engagement of CD28 leads to tyrosine phosphorylation of its cytoplasmic region and recruitment of cytoplasmic signaling proteins. Altho
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ae2aab12a5706d0586d36ce9cba4f656
https://ora.ox.ac.uk/objects/uuid:ea26fbe4-3aa4-466b-ad45-4f89bcabd0df
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6
Glycogen synthase kinase 3 inactivation drives T-bet-mediated downregulation of co-receptor PD-1 to enhance CD8+ cytolytic T cell responses
Autor: Taylor, A, Harker, JA, Chanthong, K, Stevenson, PG, Zuniga, EI, Rudd, CE
Despite the importance of the co-receptor PD-1 in T cell immunity, the upstream signaling pathway that regulates PD-1 expression has not been defined. Glycogen synthase kinase 3 (GSK-3, isoforms α and β) is a serine-threonine kinase implicated in c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::5afae04e1ecd7f15727ee0464ccbc2f6
http://hdl.handle.net/10044/1/32989
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8
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9
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10
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