Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ruda de Luna Almeida Santos"'
Autor:
Xiang Feng, Michelle M. Spiering, Ruda de Luna Almeida Santos, Stephen J. Benkovic, Huilin Li
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract The T4 bacteriophage gp41 helicase and gp61 primase assemble into a primosome to couple DNA unwinding with RNA primer synthesis for DNA replication. How the primosome is assembled and how the primer length is defined are unclear. Here we rep
Externí odkaz:
https://doaj.org/article/65c6a9d0bd20462fb5a359252ed1232a
Autor:
Ruda de Luna Almeida Santos, Lin Bai, Pradeep K. Singh, Naoka Murakami, Hao Fan, Wenhu Zhan, Yingrong Zhu, Xiuju Jiang, Kaiming Zhang, Jean Pierre Assker, Carl F. Nathan, Huilin Li, Jamil Azzi, Gang Lin
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Immunoproteasome selective inhibitors might lead to less toxic drugs for treatment of multiple myeloma and graft rejection. Here, the authors develop immunoproteasome specific asparagine-ethylenediamine (AsnEDA)-based inhibitory compounds, demonstrat
Externí odkaz:
https://doaj.org/article/aaef590b4c434dd3a24ff936b3177a69
Autor:
Zuanning Yuan, Roxana Georgescu, Ruda de Luna Almeida Santos, Daniel Zhang, Lin Bai, Nina Y Yao, Gongpu Zhao, Michael E O'Donnell, Huilin Li
Publikováno v:
eLife, Vol 8 (2019)
The current view is that eukaryotic replisomes are independent. Here we show that Ctf4 tightly dimerizes CMG helicase, with an extensive interface involving Psf2, Cdc45, and Sld5. Interestingly, Ctf4 binds only one Pol α-primase. Thus, Ctf4 may have
Externí odkaz:
https://doaj.org/article/5a463b53e2944cfd8176059ff5dcaff9
Autor:
Ruda de Luna Almeida Santos, Nina Y. Yao, Lin Bai, Mike O'Donnell, Zuanning Yuan, Gongpu Zhao, Daniel Zhang, Roxana E. Georgescu, Huilin Li
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
The current view is that eukaryotic replisomes are independent. Here we show that Ctf4 tightly dimerizes CMG helicase, with an extensive interface involving Psf2, Cdc45, and Sld5. Interestingly, Ctf4 binds only one Pol α-primase. Thus, Ctf4 may have
Autor:
Lin Bai, Gongpu Zhao, Mike O'Donnell, Daniel Zhang, Huilin Li, Roxana E. Georgescu, Zuanning Yuan, Ruda de Luna Almeida Santos, Nina Y. Yao
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07687f13ee6d917a9495cc976197c66b
https://doi.org/10.7554/elife.47405.046
https://doi.org/10.7554/elife.47405.046
Autor:
Roxana E. Georgescu, Zuanning Yuan, Ruda de Luna Almeida Santos, Bai Lin, Mike O'Donnell, Huilin Li, Dan Zhang, Olga Yurieva
Publikováno v:
The FASEB Journal. 33
Autor:
Huilin Li, Jean Pierre Assker, Jamil Azzi, Wenhu Zhan, Naoka Murakami, Lin Bai, Hao Fan, Gang Lin, Xiuju Jiang, Ruda de Luna Almeida Santos, Kaiming Zhang, Carl Nathan, Yingrong Zhu, Pradeep K. Singh
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Proteasome inhibitors benefit patients with multiple myeloma and B cell-dependent autoimmune disorders but exert toxicity from inhibition of proteasomes in other cells. Toxicity should be minimized by reversible inhibition of the immunoproteasome β5
Autor:
Huilin Li, Jingchuan Sun, Olga Yurieva, Lin Bai, Ruda de Luna Almeida Santos, Mike O'Donnell, Dan Zhang, Zuanning Yuan, Roxana E. Georgescu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(5)
The eukaryotic CMG (Cdc45, Mcm2–7, GINS) helicase consists of the Mcm2–7 hexameric ring along with five accessory factors. The Mcm2–7 heterohexamer, like other hexameric helicases, is shaped like a ring with two tiers, an N-tier ring composed o
We performed molecular modeling analysis onto a novel mutation in the gene MVK, described by Santos et al., found to be causative of a severe form of Hyper-IgD/Mevalonate Kinase Deficiency. The mutation p.R277G, in our analysis, lowers the binding af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb99ad6a1940fa3f3d4d1cd2f081781f
https://hdl.handle.net/11368/2830778
https://hdl.handle.net/11368/2830778