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Akademický článek

Antibody specificity against highly conserved membrane protein Claudin 6 driven by single atomic contact point.

Autor: Screnci B; Integral Molecular, 3711 Market Street, Suite 900, Philadelphia, PA 19104, USA., Stafford LJ; Integral Molecular, 3711 Market Street, Suite 900, Philadelphia, PA 19104, USA., Barnes T; Integral Molecular, 3711 Market Street, Suite 900, Philadelphia, PA 19104, USA., Shema K; Integral Molecular, 3711 Market Street, Suite 900, Philadelphia, PA 19104, USA., Gilman S; Integral Molecular, 3711 Market Street, Suite 900, Philadelphia, PA 19104, USA., Wright R; Integral Molecular, 3711 Market Street, Suite 900, Philadelphia, PA 19104, USA., Al Absi S; Integral Molecular, 3711 Market Street, Suite 900, Philadelphia, PA 19104, USA., Phillips T; Integral Molecular, 3711 Market Street, Suite 900, Philadelphia, PA 19104, USA., Azuelos C; Integral Molecular, 3711 Market Street, Suite 900, Philadelphia, PA 19104, USA., Slovik K; Integral Molecular, 3711 Market Street, Suite 900, Philadelphia, PA 19104, USA., Murphy P; Integral Molecular, 3711 Market Street, Suite 900, Philadelphia, PA 19104, USA., Harmon DB; Integral Molecular, 3711 Market Street, Suite 900, Philadelphia, PA 19104, USA., Charpentier T; Integral Molecular, 3711 Market Street, Suite 900, Philadelphia, PA 19104, USA., Doranz BJ; Integral Molecular, 3711 Market Street, Suite 900, Philadelphia, PA 19104, USA., Rucker JB; Integral Molecular, 3711 Market Street, Suite 900, Philadelphia, PA 19104, USA., Chambers R; Integral Molecular, 3711 Market Street, Suite 900, Philadelphia, PA 19104, USA.

Publikováno v: IScience [iScience] 2022 Nov 24; Vol. 25 (12), pp. 105665. Date of Electronic Publication: 2022 Nov 24 (Print Publication: 2022).

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Akademický článek

CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry.

Autor: Van Hout A; Department of Microbiology and Immunology, Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven, Herestraat 49, 3000 Leuven, Belgium., Klarenbeek A; Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands; argenx BVBA, Industriepark Zwijnaarde 7, 9052 Zwijnaarde, Belgium., Bobkov V; Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands; argenx BVBA, Industriepark Zwijnaarde 7, 9052 Zwijnaarde, Belgium., Doijen J; Department of Microbiology and Immunology, Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Department of Biology, Laboratory of Functional Genomics & Proteomics, Zoological Institute, KU Leuven, Naamsestraat 59, 3000 Leuven, Belgium., Arimont M; Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands., Zhao C; Department of Pharmacology, University of California, 9500 Gilman Drive, MC 0684, La Jolla, San Diego, USA., Heukers R; Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands., Rimkunas R; Integral Molecular, Inc., 3711 Market St, Suite 900, Philadelphia, PA, USA., de Graaf C; Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands., Verrips T; QVQ Holding B.V., Yalelaan 1, 3584 CL Utrecht, The Netherlands., van der Woning B; argenx BVBA, Industriepark Zwijnaarde 7, 9052 Zwijnaarde, Belgium., de Haard H; argenx BVBA, Industriepark Zwijnaarde 7, 9052 Zwijnaarde, Belgium., Rucker JB; Department of Pharmacology, University of California, 9500 Gilman Drive, MC 0684, La Jolla, San Diego, USA., Vermeire K; Department of Microbiology and Immunology, Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven, Herestraat 49, 3000 Leuven, Belgium., Handel T; Department of Pharmacology, University of California, 9500 Gilman Drive, MC 0684, La Jolla, San Diego, USA., Van Loy T; Department of Microbiology and Immunology, Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven, Herestraat 49, 3000 Leuven, Belgium., Smit MJ; Division of Medicinal Chemistry, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands., Schols D; Department of Microbiology and Immunology, Laboratory of Virology and Chemotherapy, Rega Institute, KU Leuven, Herestraat 49, 3000 Leuven, Belgium. Electronic address: dominique.schols@kuleuven.be.

Publikováno v: Biochemical pharmacology [Biochem Pharmacol] 2018 Dec; Vol. 158, pp. 402-412. Date of Electronic Publication: 2018 Oct 17.

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Akademický článek

Isolation of state-dependent monoclonal antibodies against the 12-transmembrane domain glucose transporter 4 using virus-like particles.

Autor: Tucker DF; Integral Molecular, Philadelphia, PA 19104., Sullivan JT; Integral Molecular, Philadelphia, PA 19104., Mattia KA; Integral Molecular, Philadelphia, PA 19104., Fisher CR; Integral Molecular, Philadelphia, PA 19104., Barnes T; Integral Molecular, Philadelphia, PA 19104., Mabila MN; Integral Molecular, Philadelphia, PA 19104., Wilf R; Integral Molecular, Philadelphia, PA 19104., Sulli C; Integral Molecular, Philadelphia, PA 19104., Pitts M; Integral Molecular, Philadelphia, PA 19104., Payne RJ; Integral Molecular, Philadelphia, PA 19104., Hall M; Integral Molecular, Philadelphia, PA 19104., Huston-Paterson D; Integral Molecular, Philadelphia, PA 19104., Deng X; Integral Molecular, Philadelphia, PA 19104., Davidson E; Integral Molecular, Philadelphia, PA 19104., Willis SH; Integral Molecular, Philadelphia, PA 19104., Doranz BJ; Integral Molecular, Philadelphia, PA 19104., Chambers R; Integral Molecular, Philadelphia, PA 19104., Rucker JB; Integral Molecular, Philadelphia, PA 19104 jrucker@integralmolecular.com.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 May 29; Vol. 115 (22), pp. E4990-E4999. Date of Electronic Publication: 2018 May 16.

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Akademický článek

The Bitter Taste Receptor TAS2R16 Achieves High Specificity and Accommodates Diverse Glycoside Ligands by using a Two-faced Binding Pocket.

Autor: Thomas A; Integral Molecular, Inc., 3711 Market St, Suite 900, Philadelphia, PA, 19104, USA., Sulli C; Integral Molecular, Inc., 3711 Market St, Suite 900, Philadelphia, PA, 19104, USA., Davidson E; Integral Molecular, Inc., 3711 Market St, Suite 900, Philadelphia, PA, 19104, USA., Berdougo E; Integral Molecular, Inc., 3711 Market St, Suite 900, Philadelphia, PA, 19104, USA., Phillips M; Integral Molecular, Inc., 3711 Market St, Suite 900, Philadelphia, PA, 19104, USA., Puffer BA; Integral Molecular, Inc., 3711 Market St, Suite 900, Philadelphia, PA, 19104, USA., Paes C; Integral Molecular, Inc., 3711 Market St, Suite 900, Philadelphia, PA, 19104, USA., Doranz BJ; Integral Molecular, Inc., 3711 Market St, Suite 900, Philadelphia, PA, 19104, USA., Rucker JB; Integral Molecular, Inc., 3711 Market St, Suite 900, Philadelphia, PA, 19104, USA. jrucker@integralmolecular.com.

Publikováno v: Scientific reports [Sci Rep] 2017 Aug 10; Vol. 7 (1), pp. 7753. Date of Electronic Publication: 2017 Aug 10.

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Akademický článek

Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices.

Autor: Wescott MP; Integral Molecular, Philadelphia, PA 19104;, Kufareva I; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093., Paes C; Integral Molecular, Philadelphia, PA 19104;, Goodman JR; Integral Molecular, Philadelphia, PA 19104;, Thaker Y; Integral Molecular, Philadelphia, PA 19104;, Puffer BA; Integral Molecular, Philadelphia, PA 19104;, Berdougo E; Integral Molecular, Philadelphia, PA 19104;, Rucker JB; Integral Molecular, Philadelphia, PA 19104;, Handel TM; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093., Doranz BJ; Integral Molecular, Philadelphia, PA 19104; bdoranz@integralmolecular.com.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2016 Aug 30; Vol. 113 (35), pp. 9928-33. Date of Electronic Publication: 2016 Aug 19.

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Akademický článek

Mechanism of Binding to Ebola Virus Glycoprotein by the ZMapp, ZMAb, and MB-003 Cocktail Antibodies.

Autor: Davidson E; Integral Molecular, Philadelphia, Pennsylvania, USA., Bryan C; Integral Molecular, Philadelphia, Pennsylvania, USA., Fong RH; Integral Molecular, Philadelphia, Pennsylvania, USA., Barnes T; Integral Molecular, Philadelphia, Pennsylvania, USA., Pfaff JM; Integral Molecular, Philadelphia, Pennsylvania, USA., Mabila M; Integral Molecular, Philadelphia, Pennsylvania, USA., Rucker JB; Integral Molecular, Philadelphia, Pennsylvania, USA., Doranz BJ; Integral Molecular, Philadelphia, Pennsylvania, USA bdoranz@integralmolecular.com.

Publikováno v: Journal of virology [J Virol] 2015 Nov; Vol. 89 (21), pp. 10982-92. Date of Electronic Publication: 2015 Aug 26.

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Akademický článek

Thermal green protein, an extremely stable, nonaggregating fluorescent protein created by structure-guided surface engineering.

Autor: Close DW; Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico.; Center for Integrated Nanotechnologies, Los Alamos National Laboratory, Los Alamos, New Mexico., Paul CD; Department of Biochemistry and Molecular Biology, Monash University, Clayton Campus, Melbourne, Victoria, Australia., Langan PS; Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico., Wilce MC; Department of Biochemistry and Molecular Biology, Monash University, Clayton Campus, Melbourne, Victoria, Australia., Traore DA; Department of Biochemistry and Molecular Biology, Monash University, Clayton Campus, Melbourne, Victoria, Australia., Halfmann R; Department of Biochemistry, UT Southwestern Medical Center, Dallas, Texas., Rocha RC; Center for Integrated Nanotechnologies, Los Alamos National Laboratory, Los Alamos, New Mexico., Waldo GS; Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico., Payne RJ; Integral Molecular, Philadelphia, Pennsylvania., Rucker JB; Integral Molecular, Philadelphia, Pennsylvania., Prescott M; Department of Biochemistry and Molecular Biology, Monash University, Clayton Campus, Melbourne, Victoria, Australia., Bradbury AR; Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico.

Publikováno v: Proteins [Proteins] 2015 Jul; Vol. 83 (7), pp. 1225-37. Date of Electronic Publication: 2015 May 08.

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Akademický článek

A functional comparison of the domestic cat bitter receptors Tas2r38 and Tas2r43 with their human orthologs.

Autor: Sandau MM; AFB International, St. Charles, MO, USA. msandau@afbinternational.com., Goodman JR; Integral Molecular, Inc., Philadelphia, PA, USA. jrg5032@gmail.com., Thomas A; Integral Molecular, Inc., Philadelphia, PA, USA. athomas@integralmolecular.com., Rucker JB; Integral Molecular, Inc., Philadelphia, PA, USA. jrucker@integralmolecular.com., Rawson NE; AFB International, St. Charles, MO, USA. nrawson@afbinternational.com.

Publikováno v: BMC neuroscience [BMC Neurosci] 2015 Jun 03; Vol. 16, pp. 33. Date of Electronic Publication: 2015 Jun 03.

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