RNA Editing by ADAR Adenosine Deaminases in the Cell Models of CAG Repeat Expansion Diseases: Significant Effect of Differentiation from Stem Cells into Brain Organoids in the Absence of Substantial Influence of CAG Repeats on the Level of Editing.

Autor: Kudriavskii VV; Pirogov Russian National Research Medical University, Moscow, 117997, Russia.; Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, 119435, Russia.; Center for Molecular and Cellular Biology, Skolkovo Institute of Science and Technology, Moscow, 121205, Russia. wkudriavskii@gmail.com., Goncharov AO; Pirogov Russian National Research Medical University, Moscow, 117997, Russia.; Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, 119435, Russia., Eremeev AV; Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, 119435, Russia., Ruchko ES; Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, 119435, Russia., Veselovsky VA; Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, 119435, Russia., Klimina KM; Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, 119435, Russia., Bogomazova AN; Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, 119435, Russia., Lagarkova MA; Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, 119435, Russia., Moshkovskii SA; Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, 119435, Russia.; Institute of Biomedical Chemistry, Moscow, 119121, Russia.; Max Planck Institute for Interdisciplinary Research, Göttingen, 37077, Germany. moshrffi@gmail.com., Kliuchnikova AA; Pirogov Russian National Research Medical University, Moscow, 117997, Russia.; Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, 119435, Russia.; Institute of Biomedical Chemistry, Moscow, 119121, Russia.

Publikováno v: Biochemistry. Biokhimiia [Biochemistry (Mosc)] 2024 Aug; Vol. 89 (8), pp. 1474-1489.