Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Ruchita R. Thakore"'
Publikováno v:
Organics, Vol 3, Iss 1, Pp 1-21 (2022)
Cross-coupling reactions have changed the way complex molecules are synthesized. In particular, Suzuki–Miyaura and Buchwald–Hartwig amination reactions have given opportunities to elegantly make pharmaceutical ingredients. Indeed, these reactions
Externí odkaz:
https://doaj.org/article/7f3bc49e0272443c86f1f68fde1192f6
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 691-737 (2020)
Numerous reactions generating C–Si and C–B bonds are in focus owing to the importance of incorporating silicon or boron into new or existing drugs, in addition to their use as building blocks in cross-coupling reactions en route to various target
Externí odkaz:
https://doaj.org/article/dbd295871c714aa788edf2bb0163339b
Autor:
Joseph R. A. Kincaid, Rahul D. Kavthe, Juan C. Caravez, Balaram S. Takale, Ruchita R. Thakore, Bruce H. Lipshutz
Publikováno v:
Organic Letters. 24:3342-3346
Two routes to the antimalarial drug Pyronaridine are described. The first is a linear sequence that includes a two-step, one-pot transformation in an aqueous surfactant medium, leading to an overall yield of 87%. Alternatively, a convergent route uti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfab764c649beb242443a9d3246727a5
https://doi.org/10.1021/acs.orglett.2c00944
https://doi.org/10.1021/acs.orglett.2c00944
Publikováno v:
Organic Letters. 23:8114-8118
Commercially available Pd/C can be used as a catalyst for nitro group reductions with only 0.4 mol % Pd loading. The reaction can be performed using either silane as a transfer hydrogenating agent or simply a hydrogen balloon (∼1 atm pressure). Wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57202f3b8487a58748ba509f46935ee0
https://doi.org/10.1021/acs.orglett.1c03258
https://doi.org/10.1021/acs.orglett.1c03258
Autor:
Bruce H. Lipshutz, Xiaohan Li, David K. Leahy, Ruchita R. Thakore, Karthik S. Iyer, J. Daniel Bailey
Publikováno v:
Organic Letters. 23:7205-7208
Highly valued products resulting from reductive aminations utilizing shelf-stable bisulfite addition compounds of aldehydes can be made under aqueous micellar catalysis conditions. Readily available α-picolineborane serves as the stoichiometric hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::269040d8b0599fb3490c90e37b081674
https://doi.org/10.1021/acs.orglett.1c02604
https://doi.org/10.1021/acs.orglett.1c02604
Autor:
Gianluca Casotti, Fabrice Gallou, Balaram S. Takale, Ruchita R. Thakore, Bruce H. Lipshutz, Xiaohan Li
Publikováno v:
Angewandte Chemie. 133:4204-4209
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f67cf8b23ae27a9ec9f58a728dec77d
https://doi.org/10.1002/ange.202014141
https://doi.org/10.1002/ange.202014141
Autor:
Xaiohan Li, Ruchita R. Thakore, Gianluca Casotti, Fabrice Gallou, Balaram S. Takale, Bruce H. Lipshutz
Publikováno v:
Angewandte Chemie International Edition. 60:4158-4163
An inexpensive and new triphenylphosphine-based palladacycle has been developed as a pre-catalyst, leading to highly effective Stille cross-coupling reactions in water under mild reaction conditions. Only 500-1000 ppm of Pd suffices for couplings inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fb6f623c7ade4956ba86c92b129b98f
https://doi.org/10.1002/anie.202014141
https://doi.org/10.1002/anie.202014141
Publikováno v:
ChemCatChem. 13:212-216
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e953f4d7dce312e128789f7d3d870e6
https://doi.org/10.1002/cctc.202001742
https://doi.org/10.1002/cctc.202001742
Autor:
Ruchita R. Thakore, Eugene S. Gao, Henry S. Jin, Gianluca Casotti, Balaram S. Takale, Bruce H. Lipshutz
Publikováno v:
Organic Letters. 22:6324-6329
Condensation in recyclable water between aldehydes or ketones and amines occurs smoothly within the hydrophobic cores of nanomicelles, resulting in imine formation that is subject to subsequent reduction leading, overall, to reductive amination. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d4d1dbb5282b6a29fce7c705df1492b
https://doi.org/10.1021/acs.orglett.0c02156
https://doi.org/10.1021/acs.orglett.0c02156
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 691-737 (2020)
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry
Numerous reactions generating C–Si and C–B bonds are in focus owing to the importance of incorporating silicon or boron into new or existing drugs, in addition to their use as building blocks in cross-coupling reactions en route to various target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cebaf1dc1bae59445cb6b7c35ed93e4b
https://doaj.org/article/dbd295871c714aa788edf2bb0163339b
https://doaj.org/article/dbd295871c714aa788edf2bb0163339b