Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Ruchira Basu"'
Autor:
Sijie Chen, Tong Lin, Ruchira Basu, Jeremy Ritchey, Shen Wang, Yichuan Luo, Xingcan Li, Dehua Pei, Levent Burak Kara, Xiaolin Cheng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract We introduce a computational approach for the design of target-specific peptides. Our method integrates a Gated Recurrent Unit-based Variational Autoencoder with Rosetta FlexPepDock for peptide sequence generation and binding affinity assess
Externí odkaz:
https://doaj.org/article/9abaf5b6631f4e708716d36d49b36a97
Autor:
Sijie Chen, Tong Lin, Ruchira Basu, Shen Wang, Yichuan Luo, Levent Kara, Dehua Pei, Xiaolin Cheng
Computational design of therapeutic peptides that enables fast exploration of a combinatorial number of amino acid possibilities has emerged as a popular strategy in antibiotics discovery but identifying peptide inhibitors targeting specific protein-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f37452ec277e9f6f61739422f6124dee
https://doi.org/10.21203/rs.3.rs-2019700/v1
https://doi.org/10.21203/rs.3.rs-2019700/v1
Autor:
Ashweta Sahni, George Appiah Kubi, Ziqing Qian, Jian-Guo Ren, Amritendu Koley, Patrick G Dougherty, Jin Wen, Ruchira Basu, Xiaoyan Pan, Dehua Pei, Heba Salim
Publikováno v:
J Med Chem
Stapled peptides recapitulate the binding affinity and specificity of α-helices in proteins, resist proteolytic degradation, and may provide a novel modality against challenging drug targets such as protein-protein interactions. However, most of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8209ea802cefe2b26a8c964426c9034b
https://doi.org/10.1021/acs.jmedchem.9b00456
https://doi.org/10.1021/acs.jmedchem.9b00456
Autor:
Edamana Prasad, Sanjib Senapati, Vignesh Muthuvijayan, Palani Prabakaran, Ruchira Basu, Chinmai Pindi, Ramya Kannan
Publikováno v:
ACS Applied Bio Materials. 2:3212-3224
The increased threat of bacterial resistance against conventional antibiotics has warranted the need for development of membrane targeting antibacterial agents. Several self-assembled cationic amphiphiles with different supramolecular structures have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f997a35507978b180555ab74069c8dad
https://doi.org/10.1021/acsabm.9b00140
https://doi.org/10.1021/acsabm.9b00140