Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Ruchir R Shah"'
Publikováno v:
Bioinformatics and Biology Insights, Vol 16 (2022)
High-throughput transcriptomics has advanced through the introduction of TempO-seq, a targeted alternative to traditional RNA-seq. TempO-seq platforms use 50 nucleotide probes, each specifically designed to target a known transcript, thus allowing fo
Externí odkaz:
https://doaj.org/article/8b28616d97a847abbaf8053d0e0e327a
Autor:
Deepak Mav, Dhiral P Phadke, Michele R Balik-Meisner, B Alex Merrick, Scott Auerbach, Marije Niemeijer, Suzanna Huppelschoten, Audrey Baze, Celine Parmentier, Lysiane Richert, Bob van de Water, Ruchir R Shah, Richard S Paules
Publikováno v:
Bioinformatics and Biology Insights, Vol 14 (2020)
The TempO-Seq S1500+ platform(s), now available for human, mouse, rat, and zebrafish, measures a discrete number of genes that are representative of biological and pathway co-regulation across the entire genome in a given species. While measurement o
Externí odkaz:
https://doaj.org/article/d6f389cb95e54e188488ba1e4c1a51c4
Autor:
Lucie C. Ford, Hsing-Chieh Lin, Yi-Hui Zhou, Fred A. Wright, Vijay K. Gombar, Alexander Sedykh, Ruchir R. Shah, Weihsueh A. Chiu, Ivan Rusyn
Publikováno v:
Human Genomics, Vol 18, Iss 1, Pp 1-23 (2024)
Abstract Per- and poly-fluoroalkyl substances (PFAS) are emerging contaminants of concern because of their wide use, persistence, and potential to be hazardous to both humans and the environment. Several PFAS have been designated as substances of con
Externí odkaz:
https://doaj.org/article/f47bcede66d34ab4b2df16aa5b31cf55
Autor:
Deepak Mav, Ruchir R Shah, Brian E Howard, Scott S Auerbach, Pierre R Bushel, Jennifer B Collins, David L Gerhold, Richard S Judson, Agnes L Karmaus, Elizabeth A Maull, Donna L Mendrick, B Alex Merrick, Nisha S Sipes, Daniel Svoboda, Richard S Paules
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0191105 (2018)
Changes in gene expression can help reveal the mechanisms of disease processes and the mode of action for toxicities and adverse effects on cellular responses induced by exposures to chemicals, drugs and environment agents. The U.S. Tox21 Federal col
Externí odkaz:
https://doaj.org/article/ac4c3100313c431db2f048cc682fb4c1
Autor:
B Alex Merrick, Justin S Chang, Dhiral P Phadke, Meredith A Bostrom, Ruchir R Shah, Xinguo Wang, Oksana Gordon, Garron M Wright
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190992 (2018)
The transcriptome can reveal insights into precancer biology. We recently conducted RNA-Seq analysis on liver RNA from male rats exposed to the carcinogen, aflatoxin B1 (AFB1), for 90 days prior to liver tumor onset. Among >1,000 differentially expre
Externí odkaz:
https://doaj.org/article/25bd8608d23d4629a3f9705634361845
Autor:
Archana Hari, Mohamed Diwan M. AbdulHameed, Michele R. Balik-Meisner, Deepak Mav, Dhiral P. Phadke, Elizabeth H. Scholl, Ruchir R. Shah, Warren Casey, Scott S. Auerbach, Anders Wallqvist, Venkat R. Pannala
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
Toxicants with the potential to bioaccumulate in humans and animals have long been a cause for concern, particularly due to their association with multiple diseases and organ injuries. Per- and polyfluoro alkyl substances (PFAS) and polycyclic aromat
Externí odkaz:
https://doaj.org/article/8fa9b6200c834987838ec3cbd001cc10
Autor:
B Alex Merrick, Dhiral P Phadke, Scott S Auerbach, Deepak Mav, Suzy M Stiegelmeyer, Ruchir R Shah, Raymond R Tice
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61768 (2013)
Deep sequencing was used to investigate the subchronic effects of 1 ppm aflatoxin B1 (AFB1), a potent hepatocarcinogen, on the male rat liver transcriptome prior to onset of histopathological lesions or tumors. We hypothesized RNA-Seq would reveal mo
Externí odkaz:
https://doaj.org/article/a3b59a1659ee46fb996fa3a880f22e55
Autor:
Takashi Shimbo, Ying Du, Sara A Grimm, Archana Dhasarathy, Deepak Mav, Ruchir R Shah, Huidong Shi, Paul A Wade
Publikováno v:
PLoS Genetics, Vol 9, Iss 12, p e1004028 (2013)
The Mi-2/nucleosome remodeling and histone deacetylase (NuRD) complex is a multiprotein machine proposed to regulate chromatin structure by nucleosome remodeling and histone deacetylation activities. Recent reports describing localization of NuRD pro
Externí odkaz:
https://doaj.org/article/6ef3b607ead84eed8edde246fcc1b9d1
Autor:
Lindsay K Smith, Arpit Tandon, Ruchir R Shah, Deepak Mav, Alyson B Scoltock, John A Cidlowski
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78316 (2013)
Apoptosis of lymphocytes governs the response of the immune system to environmental stress and toxic insult. Signaling through the ubiquitously expressed glucocorticoid receptor, stress-induced glucocorticoid hormones induce apoptosis via mechanisms
Externí odkaz:
https://doaj.org/article/fa9a7755c02b4a2abce104936014526b
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26514 (2011)
The transcriptional repressors Snail and Slug are situated at the core of several signaling pathways proposed to mediate epithelial to mesenchymal transition or EMT, which has been implicated in tumor metastasis. EMT involves an alteration from an or
Externí odkaz:
https://doaj.org/article/d2d91fe0a7134e46b0f1440415050e43