Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ruchika, Bhat"'
Autor:
S. Kiruthika, Ruchika Bhat, Rozaleen Dash, Anurag S. Rathore, Perumal Vivekanandan, B. Jayaram
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Chronic hepatitis B virus (HBV) infection is a global problem. The loss of hepatitis B surface antigen (HBsAg) in serum is a therapeutic end point. Prolonged therapy with nucleoside/nucleotide analogues targeting the HBV-polymerase may lead
Externí odkaz:
https://doaj.org/article/828e02fbb00e495fa7ffa456010521c4
Publikováno v:
Journal of Antimicrobial Chemotherapy. 77:2120-2124
Background Currently approved oral antivirals for chronic HBV infection target the reverse transcriptase (RT) domain of the HBV polymerase. Emergence of drug resistance has been reported in a small proportion of chronic HBV patients on prolonged trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc72f6e164ff6373dc39e267de3c9e1
https://doi.org/10.1093/jac/dkac148
https://doi.org/10.1093/jac/dkac148
Autor:
Mladen Jergović, Makiko Watanabe, Ruchika Bhat, Christopher P. Coplen, Sandip A. Sonar, Rachel Wong, Yvonne Castaneda, Lisa Davidson, Mrinalini Kala, Rachel C. Wilson, Homer L. Twigg, Kenneth Knox, Heidi E. Erickson, Craig C. Weinkauf, Christian Bime, Billie A. Bixby, Sairam Parthasarathy, Jarrod M. Mosier, Bonnie J. LaFleur, Deepta Bhattacharya, Janko Z. Nikolich
In children and younger adults up to 39 years of age, SARS-CoV-2 usually elicits mild symptoms that resemble the common cold. Disease severity increases with age starting at 30 and reaches astounding mortality rates that are ~330 fold higher in perso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e3d8c8cdee334479fc6e1f177a41e50
https://doi.org/10.1101/2022.12.21.521463
https://doi.org/10.1101/2022.12.21.521463
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 40:11625-11637
The pharmacologically characterized receptor subtype of the serotonin family, the 5HT1A receptor is implicated in the pathophysiology and treatment of depression and anxiety-related disorders. Being the most extensively targeted receptor for developi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b65e66c79baa6082fd29caa3129195b
https://doi.org/10.1080/07391102.2021.1961865
https://doi.org/10.1080/07391102.2021.1961865
Autor:
Ashok Kumar Patel, Siva Raghavendhar B, Naushad Khan, Kaja Murali-Krishna, Kaustuv Nayak, Anmol Chandele, Pratima Ray, Ruchika Bhat, Vineet Jain
Publikováno v:
Microbiology and Immunology. 65:290-301
Chikungunya virus (CHIKV), an arthropod-borne Alphavirus is responsible for chikungunya disease. Arthralgia and arthritis are the major symptom. Some patients recover early while others for a very long time. This study provides, epidemiology and mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94ca531126734c1574ad866d7779dc4b
https://doi.org/10.1111/1348-0421.12869
https://doi.org/10.1111/1348-0421.12869
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 39:1373-1385
Chikungunya virus (CHIKV) has emerged as a major viral threat, affecting over a million people worldwide per year. It is a vector borne disease transmitted to the human by Ades mosquitoes and primarily affect people by causing viral fever, severe joi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a846ade162218f759914a748c059709b
https://doi.org/10.1080/07391102.2020.1731602
https://doi.org/10.1080/07391102.2020.1731602
Publikováno v:
Journal of biomolecular structuredynamics. 40(22)
The pharmacologically characterized receptor subtype of the serotonin family, the 5HT1A receptor is implicated in the pathophysiology and treatment of depression and anxiety-related disorders. Being the most extensively targeted receptor for developi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::45a1df6c0fa0d6af2a906272b850bab7
https://pubmed.ncbi.nlm.nih.gov/34387135
https://pubmed.ncbi.nlm.nih.gov/34387135
Autor:
Bhyravabhotla Jayaram, Ruchika Bhat, Perumal Vivekanandan, Anurag S. Rathore, S Kiruthika, Rozaleen Dash
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Chronic hepatitis B virus (HBV) infection is a global problem. The loss of hepatitis B surface antigen (HBsAg) in serum is a therapeutic end point. Prolonged therapy with nucleoside/nucleotide analogues targeting the HBV-polymerase may lead to resist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::570cc62353d3dffa1450f4db0d7b3f1a
https://pubmed.ncbi.nlm.nih.gov/34083665
https://pubmed.ncbi.nlm.nih.gov/34083665
Publikováno v:
Protein Interactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f93efb92094fb2b6330445bbd1ea07fa
https://doi.org/10.1142/9789811211874_0015
https://doi.org/10.1142/9789811211874_0015
Publikováno v:
Journal of computer-aided molecular design. 34(8)
Scoring functions are routinely deployed in structure-based drug design to quantify the potential for protein–ligand (PL) complex formation. Here, we present a new scoring function Bappl+ that is designed to predict the binding affinities of non-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abb561d40a0e511ef9ead5656e9130e1
https://pubmed.ncbi.nlm.nih.gov/32185583
https://pubmed.ncbi.nlm.nih.gov/32185583