Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Ruchi M. Newman"'
Autor:
Vinita R Joshi, Ruchi M Newman, Melissa L Pack, Karen A Power, James B Munro, Ken Okawa, Navid Madani, Joseph G Sodroski, Aaron G Schmidt, Todd M Allen
Publikováno v:
PLoS Pathogens, Vol 16, Iss 5, p e1008577 (2020)
The HIV-1 envelope glycoprotein (Env) mediates viral entry via conformational changes associated with binding the cell surface receptor (CD4) and coreceptor (CCR5/CXCR4), resulting in subsequent fusion of the viral and cellular membranes. While the g
Externí odkaz:
https://doaj.org/article/e3859f10b003443bab3cc267b1c5c2ec
Autor:
David R. Collins, Michael T. Waring, Gaurav D. Gaiha, Olivia Mae Waring, Todd M. Allen, Bruce D. Walker, Karen A. Power, Jonathan M. Urbach, Musie Ghebremichael, Daniel P Worrall, Elizabeth J. Rossin, James Chodosh, Itai Muzhingi, Chioma Nwonu, Melis N. Anahtar, Christian Landeros, Alicja Piechocka-Trocha, Ruchi M. Newman
Publikováno v:
Science. 364:480-484
Structure-based immunogen design Vaccine design for highly mutable pathogens is hindered by a paucity of conserved immunogenic epitopes. Gaiha et al. employed a structure-based technique using network theory to assign scores to protein structure in o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::656f08b8340c64078dc359cac0fda4b0
https://doi.org/10.1126/science.aav5095
https://doi.org/10.1126/science.aav5095
Autor:
Vivien G Dugan, Scott J Emrich, Gloria I Giraldo-Calderón, Omar S Harb, Ruchi M Newman, Brett E Pickett, Lynn M Schriml, Timothy B Stockwell, Christian J Stoeckert, Dan E Sullivan, Indresh Singh, Doyle V Ward, Alison Yao, Jie Zheng, Tanya Barrett, Bruce Birren, Lauren Brinkac, Vincent M Bruno, Elizabet Caler, Sinéad Chapman, Frank H Collins, Christina A Cuomo, Valentina Di Francesco, Scott Durkin, Mark Eppinger, Michael Feldgarden, Claire Fraser, W Florian Fricke, Maria Giovanni, Matthew R Henn, Erin Hine, Julie Dunning Hotopp, Ilene Karsch-Mizrachi, Jessica C Kissinger, Eun Mi Lee, Punam Mathur, Emmanuel F Mongodin, Cheryl I Murphy, Garry Myers, Daniel E Neafsey, Karen E Nelson, William C Nierman, Julia Puzak, David Rasko, David S Roos, Lisa Sadzewicz, Joana C Silva, Bruno Sobral, R Burke Squires, Rick L Stevens, Luke Tallon, Herve Tettelin, David Wentworth, Owen White, Rebecca Will, Jennifer Wortman, Yun Zhang, Richard H Scheuermann
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99979 (2014)
High throughput sequencing has accelerated the determination of genome sequences for thousands of human infectious disease pathogens and dozens of their vectors. The scale and scope of these data are enabling genotype-phenotype association studies to
Externí odkaz:
https://doaj.org/article/7ea0c224c6f4484e9585bedb61a17966
Autor:
Kevin R McCarthy, Aaron G Schmidt, Andrea Kirmaier, Allison L Wyand, Ruchi M Newman, Welkin E Johnson
Publikováno v:
PLoS Pathogens, Vol 9, Iss 5, p e1003352 (2013)
Retroviral capsid recognition by Trim5 blocks productive infection. Rhesus macaques harbor three functionally distinct Trim5 alleles: Trim5α(Q) , Trim5α(TFP) and Trim5(CypA) . Despite the high degree of amino acid identity between Trim5α(Q) and Tr
Externí odkaz:
https://doaj.org/article/cc4aea0d010d48b0a88a0974b0bde07e
Autor:
Alexander R Macalalad, Michael C Zody, Patrick Charlebois, Niall J Lennon, Ruchi M Newman, Christine M Malboeuf, Elizabeth M Ryan, Christian L Boutwell, Karen A Power, Doug E Brackney, Kendra N Pesko, Joshua Z Levin, Gregory D Ebel, Todd M Allen, Bruce W Birren, Matthew R Henn
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 3, p e1002417 (2012)
Viruses diversify over time within hosts, often undercutting the effectiveness of host defenses and therapeutic interventions. To design successful vaccines and therapeutics, it is critical to better understand viral diversification, including compre
Externí odkaz:
https://doaj.org/article/d0f6528648654fda9f716991047631fb
Autor:
Andrea Kirmaier, Fan Wu, Ruchi M Newman, Laura R Hall, Jennifer S Morgan, Shelby O'Connor, Preston A Marx, Mareike Meythaler, Simoy Goldstein, Alicia Buckler-White, Amitinder Kaur, Vanessa M Hirsch, Welkin E Johnson
Publikováno v:
PLoS Biology, Vol 8, Iss 8, p e1000462 (2010)
Simian immunodeficiency viruses of sooty mangabeys (SIVsm) are the source of multiple, successful cross-species transmissions, having given rise to HIV-2 in humans, SIVmac in rhesus macaques, and SIVstm in stump-tailed macaques. Cellular assays and p
Externí odkaz:
https://doaj.org/article/2b323af8d509493d92d86801abf66822
Autor:
Ruchi M Newman, Laura Hall, Andrea Kirmaier, Lu-Ann Pozzi, Erez Pery, Michael Farzan, Shawn P O'Neil, Welkin Johnson
Publikováno v:
PLoS Pathogens, Vol 4, Iss 2, p e1000003 (2008)
The TRIM family proteins share a conserved arrangement of three adjacent domains, an N-terminal RING domain, followed by one or two B-boxes and a coiled-coil, which constitutes the tripartite-motif for which the family is named. However, the C-termin
Externí odkaz:
https://doaj.org/article/29f33c7bf34a45209fc781c47baee4e1
Autor:
Xiao-Dong Lian, Umar Arshad, Bruce D. Walker, Jonathan M. Urbach, Adrienne G. Yanez, Todd M. Allen, David R. Collins, Michael J. Peluso, Ngoc L. Ly, Ruchi M. Newman, Anna Rull, Yelizaveta Rassadkina, Xu G. Yu, Zachary J. Racenet, Gaurav D. Gaiha, Karen A. Power, Francesc Vidal, Geetha H. Mylvaganam, Steven G. Deeks, Mathias Lichterfeld
Publikováno v:
Immunity
Summary Spontaneous control of HIV infection has been repeatedly linked to antiviral CD8+ T cells but is not always permanent. To address mechanisms of durable and aborted control of viremia, we evaluated immunologic and virologic parameters longitud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1304130bfbb769838275fe1eb022da3
https://doi.org/10.1016/j.immuni.2021.08.007
https://doi.org/10.1016/j.immuni.2021.08.007
Autor:
Robert C. Colgrove, Anthony Griffiths, Ruchi M. Newman, Xueqiao Liu, Priya Raja, Neal A. DeLuca, David M. Knipe, Donald M. Coen
Publikováno v:
Virology. 487:215-221
A collection of genomic DNA sequences of herpes simplex virus (HSV) strains has been defined and analyzed, and some information is available about genomic stability upon limited passage of viruses in culture. The nature of genomic change upon extensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6be11fb62e0d1a9774e139ff7135f74
https://doi.org/10.1016/j.virol.2015.09.026
https://doi.org/10.1016/j.virol.2015.09.026
Autor:
Gaurav D, Gaiha, Elizabeth J, Rossin, Jonathan, Urbach, Christian, Landeros, David R, Collins, Chioma, Nwonu, Itai, Muzhingi, Melis N, Anahtar, Olivia M, Waring, Alicja, Piechocka-Trocha, Michael, Waring, Daniel P, Worrall, Musie S, Ghebremichael, Ruchi M, Newman, Karen A, Power, Todd M, Allen, James, Chodosh, Bruce D, Walker
Publikováno v:
Science (New York, N.Y.). 364(6439)
Mutationally constrained epitopes of variable pathogens represent promising targets for vaccine design but are not reliably identified by sequence conservation. In this study, we employed structure-based network analysis, which applies network theory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f70a088038a31a24bb6bf6fcf5355a4d
https://pubmed.ncbi.nlm.nih.gov/31048479
https://pubmed.ncbi.nlm.nih.gov/31048479