Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Rucha Sawlekar"'
Autor:
Stefano Magni, Rucha Sawlekar, Christophe M. Capelle, Vera Tslaf, Alexandre Baron, Ni Zeng, Laurent Mombaerts, Zuogong Yue, Ye Yuan, Feng Q. Hefeng, Jorge Gonçalves
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract The discovery of upstream regulatory genes of a gene of interest still remains challenging. Here we applied a scalable computational method to unbiasedly predict candidate regulatory genes of critical transcription factors by searching the w
Externí odkaz:
https://doaj.org/article/ed7e7d476a09458eb90fc0009e2c3a12
Autor:
Alexandre Baron, Christophe Chapelle, Rucha Sawlekar, Zuogong Yue, Laurent Mombaerts, Yuan Ye, Zeng Ni, Feng He, Stefano Magni, Jorge Goncalves
Regulatory T cells (Tregs), characterized as a CD4+CD25+FOXP3+ subset of T cells, are vital to the induction of immune tolerance and the maintenance of immune homeostasis. While target genes of Treg master regulator FOXP3 have been identified, the up
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c244a4ac6ccc8326fa1c07a6faff613
Publikováno v:
Computers & Chemical Engineering
Highlights • A new approach for the design of embedded biomolecular controllers is presented. • The approach circumvents fundamental problems in chemical reaction network theory. • The control architecture combines inverse-feedforward and feedb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5768328563464ac403c10eebe8690ef
https://eprints.whiterose.ac.uk/110628/15/1-s2.0-S0098135417300273-main.pdf
https://eprints.whiterose.ac.uk/110628/15/1-s2.0-S0098135417300273-main.pdf
Publikováno v:
Journal of Biological Engineering
Background: Cycles of covalent modification are ubiquitous motifs in cellular signalling. Although such signalling cycles are implemented via a highly concise set of chemical reactions, they have been shown to be capable of producing multiple distinc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::715853c071bd6434ec53f2a48cb4e08e
http://wrap.warwick.ac.uk/83325/7/WRAP_art%3A10.1186%2Fs13036-016-0036-1.pdf
http://wrap.warwick.ac.uk/83325/7/WRAP_art%3A10.1186%2Fs13036-016-0036-1.pdf
Publikováno v:
BioCAS
Recent advances in DNA computing have greatly facilitated the design of bimolecular circuitry based on DNA strand displacement reactions. An important issue to consider in the design process for such circuits is the effect of biological and experimen
Publikováno v:
EMBC
The use of abstract chemical reaction networks (CRNs) as a modelling and design framework for the implementation of computing and control circuits using enzyme-free, entropy driven DNA strand displacement (DSD) reactions is starting to garner widespr
Autor:
Vishwesh V. Kulkarni, Declan G. Bates, Guy-Bart Stan, Jongmin Kim, Mathias Foo, Rucha Sawlekar
Publikováno v:
ECC
European Control Conference (ECC)
European Control Conference (ECC)
Synthesis of biomolecular circuits for controlling molecular-scale processes is an important goal of synthetic biology with a wide range of in vitro and in vivo applications, including biomass maximization, nanoscale drug delivery, and many others. I
Publikováno v:
EMBC
A fundamental aim of synthetic biology is to achieve the capability to design and implement robust embedded biomolecular feedback control circuits. An approach to realize this objective is to use abstract chemical reaction networks (CRNs) as a progra
Publikováno v:
ICACCI
Bioinformatics has opened up interesting and challenging area for interdisciplinary research. One of the main component of research in bioinformatics and structural Biology is to model the protein folding phenomenon. Proteins are highly flexible obje