Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Ruby Lieshout"'
Autor:
Ruby Lieshout, Alessandra V. S. Faria, Maikel P. Peppelenbosch, Luc J. W. van der Laan, Monique M. A. Verstegen, Gwenny M. Fuhler
Publikováno v:
Molecular Medicine, Vol 28, Iss 1, Pp 1-15 (2022)
Abstract Background Cholangiocarcinoma is a rare but lethal cancer of the biliary tract. Its first-line treatment is currently restricted to chemotherapy, which provides limited clinical benefit. Kinase inhibitors targeting oncogenic intracellular si
Externí odkaz:
https://doaj.org/article/383639e6c871433fabdfa2e494969105
Autor:
Luan Nguyen, Myrthe Jager, Ruby Lieshout, Petra E. de Ruiter, Mauro D. Locati, Nicolle Besselink, Bastiaan van der Roest, Roel Janssen, Sander Boymans, Jeroen de Jonge, Jan N. M. IJzermans, Michail Doukas, Monique M. A. Verstegen, Ruben van Boxtel, Luc J. W. van der Laan, Edwin Cuppen, Ewart Kuijk
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Nguyen et al. used liver organoid cultures to identify all somatic mutations in individual stem cells from patients with common liver diseases that confer risk of cancer. The authors report that, compared to healthy liver, these precancerous liver di
Externí odkaz:
https://doaj.org/article/96839cce3bec43feb376e5547a803268
Autor:
Floris J. M. Roos, Haoyu Wu, Jorke Willemse, Ruby Lieshout, Laura A. Muñoz Albarinos, Yik‐Yang Kan, Jan‐Werner Poley, Marco J. Bruno, Jeroen deJonge, Richard Bártfai, Hendrik Marks, Jan N. M. IJzermans, Monique M. A. Verstegen, Luc J. W. van derLaan
Publikováno v:
Clinical and Translational Medicine, Vol 11, Iss 12, Pp n/a-n/a (2021)
Abstract The well‐established 3D organoid culture method enabled efficient expansion of cholangiocyte‐like cells from intrahepatic (IHBD) and extrahepatic bile duct (EHBD) tissue biopsies. The extensive expansion capacity of these organoids enabl
Externí odkaz:
https://doaj.org/article/5038a580033647ada1c8ec4149e058fa
Autor:
Michael Koch, Sandra Nickel, Ruby Lieshout, Susanna M. Lissek, Martina Leskova, Luc J. W. van der Laan, Monique M. A. Verstegen, Bruno Christ, Francesco Pampaloni
Publikováno v:
Cells, Vol 11, Iss 22, p 3613 (2022)
Monitoring tumor growth dynamics is crucial for understanding cancer. To establish an in vitro method for the continuous assessment of patient-specific tumor growth, tumor organoids were generated from patients with intrahepatic CCA (iCCA). Organoid
Externí odkaz:
https://doaj.org/article/a40efb027cfa4c9baddd774dedc0b23b
Autor:
Meng Li, Ling Wang, Yijin Wang, Shaoshi Zhang, Guoying Zhou, Ruby Lieshout, Buyun Ma, Jiaye Liu, Changbo Qu, Monique M. A. Verstegen, Dave Sprengers, Jaap Kwekkeboom, Luc J. W. van der Laan, Wanlu Cao, Maikel P. Peppelenbosch, Qiuwei Pan
Publikováno v:
Cells, Vol 9, Iss 1, p 121 (2020)
Metabolic reprogramming universally occurs in cancer. Mitochondria act as the hubs of bioenergetics and metabolism. The morphodynamics of mitochondria, comprised of fusion and fission processes, are closely associated with mitochondrial functions and
Externí odkaz:
https://doaj.org/article/04a7eeeb923643a49ec2eeb24e081bea
Autor:
Gilles S van Tienderen, Oskar Rosmark, Ruby Lieshout, Jorke Willemse, Floor de Weijer, Linda Elowsson Rendin, Gunilla Westergren-Thorsson, Michail Doukas, Bas Groot Koerkamp, Martin E van Royen, Luc JW van der Laan, Monique MA Verstegen
Publikováno v:
Acta Biomaterialia, 158, 115-131. Elsevier
Patient-derived tumor organoids have been established as promising tools for in vitro modelling of multiple tumors, including cholangiocarcinoma (CCA). However, organoids are commonly cultured in basement membrane extract (BME) which does not recapit
Autor:
Ruben van Boxtel, Nicolle Besselink, Mauro D. Locati, Sander Boymans, Ruby Lieshout, Roel Janssen, Luan Nguyen, Michail Doukas, Myrthe Jager, Ewart W. Kuijk, Edwin Cuppen, Luc J. W. van der Laan, Jeroen de Jonge, Bastiaan van der Roest, Jan N. M. IJzermans, Petra E. de Ruiter, Monique M A Verstegen
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Communications Biology, 4(1):1301. Springer Nature
Communications Biology
Communications Biology, 4(1):1301. Springer Nature
Communications Biology
Inflammatory liver disease increases the risk of developing primary liver cancer. The mechanism through which liver disease induces tumorigenesis remains unclear, but is thought to occur via increased mutagenesis. Here, we performed whole-genome sequ
Autor:
Guoying Zhou, Ruby Lieshout, Gilles S. van Tienderen, Valeska de Ruiter, Martin E. van Royen, Patrick P. C. Boor, Luc Magré, Jyaysi Desai, Kübra Köten, Yik Yang Kan, Zhouhong Ge, Lucia Campos Carrascosa, Cecile Geuijen, Dave Sprengers, Luc J. W. van der Laan, Monique M. A. Verstegen, Jaap Kwekkeboom
Publikováno v:
British Journal of Cancer, 127(4), 649-660. Nature Publishing Group
Background Immunotherapy with immune checkpoint inhibitors (ICIs) is being explored to improve cholangiocarcinoma (CCA) therapy. However, it remains difficult to predict which ICI will be effective for individual patients. Therefore, the aim of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5340ce172736b9d215c163420c585b2d
https://pure.eur.nl/en/publications/ff7205ea-851c-4c52-af5e-7b7ea9523b03
https://pure.eur.nl/en/publications/ff7205ea-851c-4c52-af5e-7b7ea9523b03
Autor:
Zhouhong Ge, Ron Smits, Lucia Campos Carrascosa, Dave Sprengers, Jaap Kwekkeboom, Jan N. M. IJzermans, Guoying Zhou, Maikel P. Peppelenbosch, Ruby Lieshout, Ling Wang, Wanlu Cao, Lisanne Noordam, Pengfei Li, Qin Yang, Junhong Su, Jiaye Liu, Luc J. W. van der Laan, Meng Li, Buyun Ma, Monique M A Verstegen, Qiuwei Pan, Ruyi Zhang
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, 11(2), 407-431. Elsevier Inc.
Cellular and Molecular Gastroenterology and Hepatology, 11(2), 407-431. Elsevier Inc.
Background & Aims Cancer-associated fibroblasts (CAFs) play a key role in the cancer process, but the research progress is hampered by the paucity of preclinical models that are essential for mechanistic dissection of cancer cell–CAF interactions.
Autor:
Ruby Lieshout, Chen Chen, Natalia Sánchez-Romero, Kerstin Schneeberger, Iris Pla Palacin, Louis C. Penning, Joery De Kock, Hans Clevers, Sabine A. Fuchs, Bart Spee, Monique E van Wolferen, Loes A Oosterhoff, Haaike Colemonts-Vroninks, Imre F. Schene, Ruurdtje Hoekstra, Pedro M. Baptista, Shicheng Ye, Luc J. W. van der Laan, Monique M A Verstegen, Gilles S van Tienderen, Frank G. van Steenbeek
Publikováno v:
Hepatology, 72(1), 257-270. John Wiley & Sons Ltd.
Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza
Hepatology (Baltimore, Md.)
Hepatology
Hepatology. American Association for the Study of Liver Diseases (AASLD)
Hepatology (Baltimore, Md.), 72(1), 257-270. John Wiley and Sons Ltd
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza
Hepatology (Baltimore, Md.)
Hepatology
Hepatology. American Association for the Study of Liver Diseases (AASLD)
Hepatology (Baltimore, Md.), 72(1), 257-270. John Wiley and Sons Ltd
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Background and Aims: The gap between patients on transplant waiting lists and available donor organs is steadily increasing. Human organoids derived from leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5)–positive adult stem cells r