Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Ruby L C Hoo"'
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65543 (2013)
OBJECTIVE: This study was designed to (1) investigate the expression profiles of resistin in db/db mice and its dynamic association with metabolic parameters; and (2) evaluate the effects of Rosiglitazone on production of resistin. METHODS: Db/db mic
Externí odkaz:
https://doaj.org/article/f9c5c290c2cb4d85ac19c8ac83d0be8a
Autor:
Lai Yee Cheong, Baile Wang, Qin Wang, Leigang Jin, Kelvin H. M. Kwok, Xiaoping Wu, Lingling Shu, Huige Lin, Sookja Kim Chung, Kenneth K. Y. Cheng, Ruby L. C. Hoo, Aimin Xu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Beiging and thermogenesis in white adipose tissue (WAT) is an important adaptive response to cold exposure, but how the brain senses cold and subsequently induces beiging remains unclear. Here, the authors show that sympathetic nerves stimulate lymph
Externí odkaz:
https://doaj.org/article/855172dea7104e12b8e6ff973eaba45e
Autor:
Xiaoping Wu, Lingling Shu, Zixuan Zhang, Jingjing Li, Jiuyu Zong, Lai Yee Cheong, Dewei Ye, Karen S. L. Lam, Erfei Song, Cunchuan Wang, Aimin Xu, Ruby L. C. Hoo
Publikováno v:
Advanced Science, Vol 8, Iss 11, Pp n/a-n/a (2021)
Abstract Development of liver fibrosis results in drastic changes in the liver microenvironment, which in turn accelerates disease progression. Although the pathological function of various hepatic cells in fibrogenesis is identified, the crosstalk b
Externí odkaz:
https://doaj.org/article/904c7664e6f44a7a9a751237616b77b9
Autor:
Lingling Shu, Ruby L. C. Hoo, Xiaoping Wu, Yong Pan, Ida P. C. Lee, Lai Yee Cheong, Stefan R Bornstein, Xianglu Rong, Jiao Guo, Aimin Xu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
The protein A-FABP is secreted from adipocytes and known to regulate glucose and lipid metabolism. Here the authors show A-FABP enhances thermogenesis by promoting the conversion of thyroxine T4 to the bioactive form, T3, in brown adipocytes, and by
Externí odkaz:
https://doaj.org/article/b7476498d71d4c13b9c088b8d15a882a
Autor:
Xiaomu Li, Kenneth K. Y. Cheng, Zhuohao Liu, Jin-Kui Yang, Baile Wang, Xue Jiang, Yawen Zhou, Philip Hallenborg, Ruby L. C. Hoo, Karen S. L. Lam, Yasuhiro Ikeda, Xin Gao, Aimin Xu
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Mice lacking the tumour suppressor p53 are partially protected from developing diabetes. Here the authors show that p53 is upregulated in the pancreas of diabetic mice where it impairs β cell function by repressing expression of mitochondrial pyruva
Externí odkaz:
https://doaj.org/article/433046fc179446af96ac4977f8bb7b86
Autor:
Han, Qiu, Erfei, Song, Yue, Hu, Tengfei, Li, Kam Ching, Ku, Cunchuan, Wang, Bernard M Y, Cheung, Lai Yee, Cheong, Qin, Wang, Xiaoping, Wu, Ruby L C, Hoo, Yong, Wang, Aimin, Xu
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology. 14:1003-1023
The prevalence of nonalcoholic fatty liver disease (NAFLD) has reached epidemic proportions globally as a result of the rapid increase in obesity. However, there is no Food and Drug Administration-approved pharmacotherapy available for NAFLD. This st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6036460af3c31987b00a3b0dca4ec367
https://doi.org/10.1016/j.jcmgh.2022.07.012
https://doi.org/10.1016/j.jcmgh.2022.07.012
Autor:
Ruby L. C. Hoo, Kenneth K.Y. Cheng, Dewei Ye, Aimin Xu, Parco M. Siu, Kelvin K.L. Wu, Huige Lin, KeKao Long
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Although mitophagy is known to restrict NLRP3 inflammasome activation, the underlying regulatory mechanism remains poorly characterized. Here we describe a type of early endosome-dependent mitophagy that limits NLRP3 inflammasome activation. Deletion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61fb84038af0d75f051063c3606b50e1
https://doaj.org/article/acd1f474dbe44e05886bd6aede2b54b2
https://doaj.org/article/acd1f474dbe44e05886bd6aede2b54b2
Autor:
Lingling Shu, Xiaoping Wu, Leigang Jin, Laiyee Cheong, Boya Liao, Zixuan Zhang, Ruby L C Hoo, Aimin Xu
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f9cea4e5b0a09bcdf5bc8d6bd1fa853
https://doi.org/10.1530/endoabs.81.ep1
https://doi.org/10.1530/endoabs.81.ep1
Autor:
Tianshi Feng, Yong Pan, Ruby L. C. Hoo, Xiaoyan Hui, Aimin Xu, Yu Wang, Karen Siu Ling Lam, Dewei Ye, Cyrus Yuk Cheung Chan
Publikováno v:
Journal of Clinical Investigation. 129:834-849
Persistent, unresolved inflammation in adipose tissue is a major contributor to obesity-associated metabolic complications. However, the molecular links between lipid-overloaded adipocytes and inflammatory immune cells in obese adipose tissues remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a563e8f6a005eb1075f991fcf7730fe
https://doi.org/10.1172/jci123069
https://doi.org/10.1172/jci123069
Autor:
Ruby L. C. Hoo, Jingjing Li, Erfei Song, Zixuan Zhang, Cunchuan Wang, Jiuyu Zong, Lai Yee Cheong, Aimin Xu, Karen S.L. Lam, Dewei Ye, Xiaoping Wu, Lingling Shu
Publikováno v:
Advanced Science, Vol 8, Iss 11, Pp n/a-n/a (2021)
Advanced Science
Advanced Science
Development of liver fibrosis results in drastic changes in the liver microenvironment, which in turn accelerates disease progression. Although the pathological function of various hepatic cells in fibrogenesis is identified, the crosstalk between th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae6d85ed44a0935212e82f7e5cdf3f60
https://doaj.org/article/904c7664e6f44a7a9a751237616b77b9
https://doaj.org/article/904c7664e6f44a7a9a751237616b77b9