Zobrazeno 1 - 10
of 857
pro vyhledávání: '"Ruby H"'
Autor:
Allison R. Sherris, Christine T. Loftus, Adam A. Szpiro, Logan C. Dearborn, Marnie F. Hazlehurst, Kecia N. Carroll, Paul E. Moore, Margaret A. Adgent, Emily S. Barrett, Nicole R. Bush, Drew B. Day, Kurunthachalam Kannan, Kaja Z. LeWinn, Ruby H. N. Nguyen, Yu Ni, Anne M. Riederer, Morgan Robinson, Sheela Sathyanarayana, Qi Zhao, Catherine J. Karr
Publikováno v:
Environmental Health, Vol 23, Iss 1, Pp 1-15 (2024)
Abstract Background and aim Studies suggest prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) may influence wheezing or asthma in preschool-aged children. However, the impact of prenatal PAH exposure on asthma and wheeze in middle childhoo
Externí odkaz:
https://doaj.org/article/862c1b4f9ef74937b4d545ce9eaaf6f1
Autor:
Kinsey Mannebach, Ruby H. N. Nguyen, Deborah Radi, Isabel J. Ricke, Mickey Scullard, Elizabeth V. Wattenberg
Publikováno v:
Public Health Reviews, Vol 45 (2024)
Externí odkaz:
https://doaj.org/article/31e3f17634cb4bf19dda8479d047d7a1
Autor:
Melissa A. Herrin, Allison R. Sherris, Logan C. Dearborn, Christine T. Loftus, Adam A. Szpiro, Paul E. Moore, Margaret A. Adgent, Emily S. Barrett, Ruby H. N. Nguyen, Kecia N. Carroll, Catherine J. Karr
Publikováno v:
Frontiers in Epidemiology, Vol 3 (2023)
BackgroundAsthma is a leading cause of childhood morbidity in the U.S. and a significant public health concern. The prenatal period is a critical window during which environmental influences, including maternal occupational exposures, can shape child
Externí odkaz:
https://doaj.org/article/8b8875355ff54df8bb79275f0b9bbf39
Autor:
Siew Siew Pang, Charles Bayly-Jones, Mazdak Radjainia, Bradley A. Spicer, Ruby H. P. Law, Adrian W. Hodel, Edward S. Parsons, Susan M. Ekkel, Paul J. Conroy, Georg Ramm, Hariprasad Venugopal, Phillip I. Bird, Bart W. Hoogenboom, Ilia Voskoboinik, Yann Gambin, Emma Sierecki, Michelle A. Dunstone, James C. Whisstock
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Macrophage-expressed gene 1 (MPEG1) functions within the phagolysosome to damage engulfed microbes, presumably via forming pores in target membranes. In order to provide insights into the mechanism of MPEG1 function and membrane binding, the authors
Externí odkaz:
https://doaj.org/article/2cd82268e003405ba51038290da8f4fe
Autor:
Erin G Sley, Emma M Rosen, Thomas J van 't Erve, Sheela Sathyanarayana, Emily S Barrett, Ruby H N Nguyen, Nicole R Bush, Ginger L Milne, Shanna H Swan, Kelly K Ferguson
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0240244 (2020)
Oxidative stress is a biological imbalance in reactive oxygen species and antioxidants. Increased oxidative stress during pregnancy has been associated with adverse birth outcomes. Omega-3 fatty acid (n-3 FA) supplementation may decrease oxidative st
Externí odkaz:
https://doaj.org/article/41b1de69348f402a86cb57cdfcd6face
Autor:
Bradley A. Spicer, Ruby H. P. Law, Tom T. Caradoc-Davies, Sue M. Ekkel, Charles Bayly-Jones, Siew-Siew Pang, Paul J. Conroy, Georg Ramm, Mazdak Radjainia, Hariprasad Venugopal, James C. Whisstock, Michelle A. Dunstone
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
The Complement component 9 (C9) is the pore-forming component of the Membrane Attack Complex which targets pathogens. Here authors use structural biology to compare monomeric C9 to C9 within the polymeric assembly and identify the element which inhib
Externí odkaz:
https://doaj.org/article/786ad92e96b04d58a33f04be085b9901
Autor:
Natalya V. Dudkina, Bradley A. Spicer, Cyril F. Reboul, Paul J. Conroy, Natalya Lukoyanova, Hans Elmlund, Ruby H. P. Law, Susan M. Ekkel, Stephanie C. Kondos, Robert J. A. Goode, Georg Ramm, James C. Whisstock, Helen R. Saibil, Michelle A. Dunstone
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-6 (2016)
The membrane attack complex is a heteromeric assembly of complement proteins where multiple copies of C9 are recruited by the C5b678 complex to form lytic pores in pathogen membranes. Here the authors present the structure of a soluble pore-like form
Externí odkaz:
https://doaj.org/article/a2649e95879f4957bec6ff1711385015
Autor:
Natalya Lukoyanova, Stephanie C Kondos, Irene Farabella, Ruby H P Law, Cyril F Reboul, Tom T Caradoc-Davies, Bradley A Spicer, Oded Kleifeld, Daouda A K Traore, Susan M Ekkel, Ilia Voskoboinik, Joseph A Trapani, Tamas Hatfaludi, Katherine Oliver, Eileen M Hotze, Rodney K Tweten, James C Whisstock, Maya Topf, Helen R Saibil, Michelle A Dunstone
Publikováno v:
PLoS Biology, Vol 13, Iss 2, p e1002049 (2015)
Membrane attack complex/perforin-like (MACPF) proteins comprise the largest superfamily of pore-forming proteins, playing crucial roles in immunity and pathogenesis. Soluble monomers assemble into large transmembrane pores via conformational transiti
Externí odkaz:
https://doaj.org/article/61da81d52f214c008c291f4ba889cd9a
Autor:
Amanda J Cork, Daniel J Ericsson, Ruby H P Law, Lachlan W Casey, Eugene Valkov, Carlo Bertozzi, Anna Stamp, Blagojce Jovcevski, J Andrew Aquilina, James C Whisstock, Mark J Walker, Bostjan Kobe
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121764 (2015)
Group A Streptococcus (GAS) is a human pathogen that has the potential to cause invasive disease by binding and activating human plasmin(ogen). Streptococcal surface enolase (SEN) is an octameric α-enolase that is localized at the GAS cell surface.
Externí odkaz:
https://doaj.org/article/03fc1f9b0db34e69a31d06cf62fa17fd
Publikováno v:
Frontiers in Aging Neuroscience, Vol 6 (2014)
This study aims to explore the potential benefits of a Chinese Chan-based lifestyle intervention on enhancing memory in older people with lower memory function. Forty-four aged 60 to 83 adults with various level of memory ability participated in the
Externí odkaz:
https://doaj.org/article/a22658b92bc543d29d2b3be58ea18fdc