Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ruby Cai"'
Autor:
Gerlinde Vansant, Zeger Debyser, Mini Balakrishnan, Frauke Christ, Ruby Cai, Anne Bruggemans, Michael L Mitchell
Publikováno v:
Antimicrob Agents Chemother
The ability of HIV to integrate into the host genome and establish latent reservoirs is the main hurdle preventing an HIV cure. LEDGINs are small-molecule integrase inhibitors that target the binding pocket of LEDGF/p75, a cellular cofactor that subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e7dd3ecb07fea2bb698f0410802d12
https://doi.org/10.1128/aac.02328-20
https://doi.org/10.1128/aac.02328-20
Autor:
Jean-Yves Christophe Chiva, Peter Pyun, Andrew John Keats, Linos Lazarides, Karine G. Poullennec, Neil Andrew Dunbar, Brian E. Schultz, Mingzhe Ji, Gregory M. Watt, Karki Kapil Kumar, Ruby Cai, Carina E. Cannizzaro, Uli Schmitz, David Kenneth Dean, Yu-Jen Lee, Sangi Michael, Victoria Alexandra Steadman, Adam J. Schrier, Simon B. Pettit, Hans G. Fliri, Adrian John Highton, Todd C. Appleby, Carol Austin, Richard L. Mackman, Caroline A. Blakemore, Hui Hon Chung, Dustin Siegel, Gregory Chin, Bernard P. Murray, Hai Yang, Yang Tian, George Stepan, Jonathan Sanvoisin, Albert Liclican, Mish Michael R, David Sperandio, Rex Santos, Petr Jansa, Haolun Jin
Publikováno v:
Journal of Medicinal Chemistry. 61:9473-9499
Cyclophilins are a family of peptidyl-prolyl isomerases that are implicated in a wide range of diseases including hepatitis C. Our aim was to discover through total synthesis an orally bioavailable, non-immunosuppressive cyclophilin (Cyp) inhibitor w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f349698a38c7c9924d318620a6fcc5d2
https://doi.org/10.1021/acs.jmedchem.8b00802
https://doi.org/10.1021/acs.jmedchem.8b00802
Autor:
Michael O'neil Hanrahan Clarke, Jie Xu, Edward Doerffler, Todd Appleby, X. Christopher Sheng, Choung U. Kim, Thomas Butler, John O. Link, William E. Delaney, Mingzhe Ji, Xiaowu Chen, Ruby Cai, Cottell Jeromy J, Hyung-Jung Pyun, Wu Qiaoyin, Aesop Cho, Rowchanak Pakdaman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:2629-2634
The discovery of GS-9451 is reported. Modification of the P3 cap and P2 quinoline with a series of solubilizing groups led to the identification of potent HCV NS3 protease inhibitors with greatly improved pharmacokinetic properties in rats, dogs and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfbcd382ed18dee42da2aee6745d1328
https://doi.org/10.1016/j.bmcl.2012.01.017
https://doi.org/10.1016/j.bmcl.2012.01.017
Autor:
Choung U. Kim, Richard W. Pastor, Matthew R. Wright, Haolun Jin, Salman Y. Jabri, Peter Pyun, Sammy Metobo, Rachael A. Lansdown, Manuel Tsiang, Ruby Cai, Xiaowu Chen, Mish Michael R
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1388-1391
A series of C5-aza tricyclic HIV integrase inhibitors was prepared. A highly potent and orally bioavailable compound (compound 9) was identified and selected for development.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ece5ac258a10ac3035a295370face10
https://doi.org/10.1016/j.bmcl.2008.01.018
https://doi.org/10.1016/j.bmcl.2008.01.018
Autor:
Zhimin Du, Jianhong Wang, Hyung-Jung Pyun, Wu Qiaoyin, Catalin Sebastian Zonte, Mingzhe Ji, Mish Michael R, Haolun Jin, Phillips Barton W, Huiling Yang, Ruby Cai, Jiayao Li, Joe Saugier, Chris Sheng, Neeraj Tirunagari, William E. Delaney, Anita Niedziela-Majka, Johnny Lee
Publikováno v:
Journal of medicinal chemistry. 57(5)
The exploration of novel inhibitors of the HCV NS4B protein that are based on a 2-oxadiazoloquinoline scaffold is described. Optimization to incorporate activity across genotypes led to a potent new series with broad activity, of which inhibitor 1 di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c265cc3a25f7abea55907e9c22f68ca
https://pubmed.ncbi.nlm.nih.gov/24512292
https://pubmed.ncbi.nlm.nih.gov/24512292
Autor:
Anthony Casarez, Aesop Cho, William E. Delaney, Choung U. Kim, Mingzhe Ji, Xiaowu Chen, Jie Xu, Edward Doerffler, Rowchanak Pakdaman, Hyung-Jung Pyun, Wu Qiaoyin, Michael O'neil Hanrahan Clarke, Mertzman Michael E, Ruby Cai, Tanisha D. Rowe, X. Christopher Sheng
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(3)
A potent and novel class of phosphinic acid derived product-like inhibitors of the HCV NS3/4A protease was discovered previously. Modification of the phosphinic acid and quinoline heterocycle led to GS-9256 with potent cell-based activity and favorab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d412dedfc5e7a35b6b72c05a1002b1f
https://pubmed.ncbi.nlm.nih.gov/22244938
https://pubmed.ncbi.nlm.nih.gov/22244938
Autor:
Schacherer Laura N, Choung U. Kim, Maria Fardis, Ruby Cai, Haolun Jin, James M. Chen, Manuel Tsiang, Xiaowu Chen, Salman Y. Jabri
Publikováno v:
ChemInform. 37
A novel class of tri-cyclic HIV integrase inhibitors were designed based on conformational analysis of 1,6-naphthyridine carboxamide compound L-870810 and docking the designed inhibitor into the active site of our integrase enzyme model. The efficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ebf617ac156d7d07c3b967d9f3556be
https://doi.org/10.1002/chin.200646188
https://doi.org/10.1002/chin.200646188
Autor:
Choung U. Kim, Maria Fardis, Mish Michael R, Ruby Cai, Manuel Tsiang, Haolun Jin, Salman Y. Jabri
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(15)
A series of novel tricyclic inhibitors of HIV-1 integrase enzyme was prepared. The effect of substitution at C-6 of the 9-hydroxy-6,7-dihydropyrrolo[3,4-g]quinolin-8-one compounds was studied in vitro. Inhibitors with small side chains at C-6 were ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c192d7119a37c3e5fbab9c0c84446b2a
https://pubmed.ncbi.nlm.nih.gov/16716589
https://pubmed.ncbi.nlm.nih.gov/16716589
Autor:
Kuei Ying Lin, Xiaowu Chen, Steve H. Krawczyk, Deborah Grant, Edmund S. Ho, Ruby Cai, Marites L. Panis, S. Swaminathan, Tomas Cihlar, Janet L. Douglas
Publikováno v:
Antimicrobial agents and chemotherapy. 49(6)
Here we present data on the mechanism of action of VP-14637 and JNJ-2408068 (formerly R-170591), two small-molecule inhibitors of respiratory syncytial virus (RSV). Both inhibitors exhibited potent antiviral activity with 50% effective concentrations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfea23187b0e83a8d2695bd1b9b3e071
https://pubmed.ncbi.nlm.nih.gov/15917547
https://pubmed.ncbi.nlm.nih.gov/15917547
Autor:
Ruby Cai, Marites L. Panis, S. Swaminathan, Janet L. Douglas, Edmund S. Ho, Kuei Ying Lin, Steve H. Krawczyk, Deborah Grant, Tomas Cihlar
Human respiratory syncytial virus (RSV) is a major cause of respiratory tract infections worldwide. Several novel small-molecule inhibitors of RSV have been identified, but they are still in preclinical or early clinical evaluation. One such inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73b6e4c918e5e798a78813b30c5a7d8
https://europepmc.org/articles/PMC153948/
https://europepmc.org/articles/PMC153948/
