Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Rubina Tuladhar"'
Autor:
Rubina Tuladhar, Yunku Yeu, John Tyler Piazza, Zhen Tan, Jean Rene Clemenceau, Xiaofeng Wu, Quinn Barrett, Jeremiah Herbert, David H. Mathews, James Kim, Tae Hyun Hwang, Lawrence Lum
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
CRISPR-Cas9 genome editing is presumed to knock out gene function by generating a frameshift during NHEJ repair. Here, the authors investigate mRNA and protein expression in edited lines and find genome editing can generate internal ribosome entry si
Externí odkaz:
https://doaj.org/article/370492b1e1f04ee38f9a459c9cce9e77
Autor:
Li-shu Zhang, Xunlei Kang, Jianming Lu, Yuannyu Zhang, Xiaofeng Wu, Guojin Wu, Junke Zheng, Rubina Tuladhar, Heping Shi, Qiaoling Wang, Lorraine Morlock, Huiyu Yao, Lily Jun-shen Huang, Pascal Maire, James Kim, Noelle Williams, Jian Xu, Chuo Chen, Cheng Cheng Zhang, Lawrence Lum
Publikováno v:
EBioMedicine, Vol 39, Iss , Pp 145-158 (2019)
Background: Chromosomal translocation-induced expression of the chromatin modifying oncofusion protein MLL-AF9 promotes acute myelocytic leukemia (AML). Whereas WNT/β-catenin signaling has previously been shown to support MLL-AF9-driven leukemogenes
Externí odkaz:
https://doaj.org/article/73d06b7f64ea44e7a85caf179ec3fdad
Autor:
Lawrence G. Lum, Jeremiah Herbert, Yuyong Ma, Chuo Chen, Chengwei Zhang, James Kim, Nageswari Yarravarapu, Rubina Tuladhar
Publikováno v:
Journal of Biological Chemistry. 294:6273-6282
The maintenance of adult animal tissues depends upon highly conserved intercellular signaling molecules that include the secreted WNT proteins. Although it is generally accepted that lipidation of WNTs by the acyltransferase Porcupine (PORCN) and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fb2afb4abe25cb5b5cc5ab2a20f1288
https://doi.org/10.1074/jbc.ra118.007268
https://doi.org/10.1074/jbc.ra118.007268
Autor:
Huiyu Yao, Junke Zheng, Li-shu Zhang, Lawrence G. Lum, Cheng Cheng Zhang, Lily Jun Shen Huang, Jianming Lu, Heping Shi, Noelle S. Williams, Pascal Maire, James Kim, Rubina Tuladhar, Lorraine Morlock, Chuo Chen, Xiaofeng Wu, Jian Xu, Xunlei Kang, Qiaoling Wang, Yuannyu Zhang, Guojin Wu
Publikováno v:
EBioMedicine
Background Chromosomal translocation-induced expression of the chromatin modifying oncofusion protein MLL-AF9 promotes acute myelocytic leukemia (AML). Whereas WNT/β-catenin signaling has previously been shown to support MLL-AF9-driven leukemogenesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f06527c59cdc183ec9e77f7aa29ac8ad
https://doi.org/10.1016/j.ebiom.2018.11.039
https://doi.org/10.1016/j.ebiom.2018.11.039
Autor:
Jason E. Toombs, Steven Y. Cheng, John Tyler Piazza, Joseph T. Opferman, Lawrence G. Lum, Quinn Barrett, Loren D. Walensky, Xuewu Zhang, Douglas R. Green, Yi Chun Kuo, Tudor Moldoveanu, Rubina Tuladhar, Rolf A. Brekken, Chih Wei Fan, Li Shu Zhang, Xiaofeng Wu, Marcel Kool
Publikováno v:
Nature Cell Biology. 19:1226-1236
Direct interactions between pro- and anti-apoptotic BCL-2 family members form the basis of cell death decision-making at the outer mitochondrial membrane (OMM). Here we report that three anti-apoptotic BCL-2 proteins (MCL-1, BCL-2 and BCL-XL) found u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd3936e3e1cccd7c58db549b65e784a
https://doi.org/10.1038/ncb3616
https://doi.org/10.1038/ncb3616
Autor:
Xiaofeng Wu, James Kim, Tae Hyun Hwang, Jean R. Clemenceau, Yunku Yeu, David H. Mathews, Jeremiah Herbert, Zhen Tan, Rubina Tuladhar, Lawrence G. Lum, John Tyler Piazza, Quinn Barrett
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
The introduction of insertion-deletions (INDELs) by non-homologous end-joining (NHEJ) pathway underlies the mechanistic basis of CRISPR-Cas9-directed genome editing. Selective gene ablation using CRISPR-Cas9 is achieved by installation of a premature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f73141b535bbfc08093f2924e7fcfa27
https://doi.org/10.1101/583138
https://doi.org/10.1101/583138
Autor:
Lawrence G. Lum, Xiaofeng Wu, Tae Hyun Hwang, David H. Mathews, James Kim, Jean R. Clemenceau, Yunku Yeu, Rubina Tuladhar, Zhen Tan, John Tyler Piazza
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03a50f74098a34ed263ed66b878162c0
https://doi.org/10.1096/fasebj.2018.32.1_supplement.649.8
https://doi.org/10.1096/fasebj.2018.32.1_supplement.649.8
Autor:
Huiyu Yao, Lily Jun Shen Huang, James Kim, Chuo Chen, Rubina Tuladhar, Junke Zheng, Cheng Cheng Zhang, Xiaofeng Wu, Lorraine Morlock, Heping Shi, Qiaoling Wang, Jian Xu, Xunlei Kang, Yuannyu Zhang, Lawrence G. Lum, Guojin Wu, Noelle S. Williams, Jianming Lu, Pascal Maire, Li-shu Zhang
Publikováno v:
SSRN Electronic Journal.
The oncofusion protein MLL-AF9 promotes acute myeloid leukemia (AML) by altering histone methylation and DNA accessibility to transcriptional machinery. Using antagonists of WNT signaling and genetic ablation of the WNT chaperone Wntless (WLS), we id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3c807fbd99d5ae189b3d0428667a617
https://doi.org/10.2139/ssrn.3266970
https://doi.org/10.2139/ssrn.3266970
Autor:
Lawrence G. Lum, Rubina Tuladhar
Publikováno v:
Biochemical Society Transactions. 43:235-239
The post-translational modification of proteins with lipid moieties confers spatial and temporal control of protein function by restricting their subcellular distribution or movement in the extracellular milieu. Yet, little is known about the signifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dcee7b92449302779d2ec833c74d7c4
https://doi.org/10.1042/bst20140282
https://doi.org/10.1042/bst20140282
Publikováno v:
Methods in Molecular Biology ISBN: 9781493963911
We describe here a technique for visualizing the lipidation status of Wnt proteins using azide-alkyne cycloaddition chemistry (click chemistry) and SDS-PAGE. This protocol incorporates in vivo labeling of a Wnt-IgG Fc fusion protein using an alkynyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57b676be436bb2790eda7ad31d3c386c
https://doi.org/10.1007/978-1-4939-6393-5_2
https://doi.org/10.1007/978-1-4939-6393-5_2