Zobrazeno 1 - 10
of 424
pro vyhledávání: '"Rubin M Tuder"'
Autor:
Biruk Kassa, Michael H Lee, Rahul Kumar, Claudia Mickael, Linda Sanders, Rubin M Tuder, Margaret Mentink-Kane, Brian B Graham
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 4, p e0010343 (2022)
BackgroundSchistosomiasis, a major cause of pulmonary arterial hypertension (PAH) worldwide, is most clearly described complicating infection by one species, Schistosoma mansoni. Controlled exposure of mice can be used to induce Type 2 inflammation-d
Externí odkaz:
https://doaj.org/article/598c70bd548d40a9ac150d51cce361c6
Autor:
Alleluiah Rutebemberwa, Mark J Stevens, Mario J Perez, Lynelle P Smith, Linda Sanders, Gregory Cosgrove, Charles E Robertson, Rubin M Tuder, J Kirk Harris
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111150 (2014)
Bacterial infection of lung airways underlies some of the main complications of COPD, significantly impacting disease progression and outcome. Colonization by bacteria may further synergize, amplify, or trigger pathways of tissue damage started by ci
Externí odkaz:
https://doaj.org/article/1f332245420f4d7dac375c688d31b0c6
Autor:
Rahul Kumar, Sushil Kumar, Claudia Mickael, Dara Fonseca Balladares, Kevin Nolan, Michael H. Lee, Linda Sanders, Julia Nilsson, Ari B. Molofsky, Rubin M. Tuder, Kurt R. Stenmark, Brian B. Graham
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundSchistosomiasis is a common cause of pulmonary hypertension (PH) worldwide. Type 2 inflammation contributes to the development of Schistosoma-induced PH. Specifically, interstitial macrophages (IMs) derived from monocytes play a pivotal rol
Externí odkaz:
https://doaj.org/article/c4fa6ee4bd3349f19baf5bada146c57a
Autor:
Almut Grenz, Julee H Dalton, Jessica D Bauerle, Alexander Badulak, Douglas Ridyard, Aneta Gandjeva, Carol M Aherne, Kelley S Brodsky, Jae-Hwan Kim, Rubin M Tuder, Holger K Eltzschig
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e14812 (2011)
The netrin family of secreted proteins provides migrational cues in the developing central nervous system. Recently, netrins have also been shown to regulate diverse processes beyond their functions in the brain, incluing the ochrestration of inflamm
Externí odkaz:
https://doaj.org/article/bd2389b7195b4a53ae4a0c92fda01e3b
Autor:
Christine U. Vohwinkel, Nana Burns, Ethan Coit, Xiaoyi Yuan, Eszter K. Vladar, Christina Sul, Eric P. Schmidt, Peter Carmeliet, Kurt Stenmark, Eva S. Nozik, Rubin M. Tuder, Holger K. Eltzschig
Publikováno v:
JCI Insight, Vol 7, Iss 24 (2022)
Acute lung injury (ALI) is a severe form of lung inflammation causing acute respiratory distress syndrome in patients. ALI pathogenesis is closely linked to uncontrolled alveolar inflammation. We hypothesize that specific enzymes of the glycolytic pa
Externí odkaz:
https://doaj.org/article/e7487e67c5aa432793b2364d3d6e26f1
Autor:
Sue Gu, Claudia Mickael, Rahul Kumar, Michael H. Lee, Linda Sanders, Biruk Kassa, Julie Harral, Jason Williams, Kirk C. Hansen, Kurt R. Stenmark, Rubin M. Tuder, Brian B. Graham
Publikováno v:
Pulmonary Circulation, Vol 12, Iss 3, Pp n/a-n/a (2022)
Abstract Right ventricular (RV) failure is the primary cause of death in pulmonary hypertension (PH), but the mechanisms of RV failure are not well understood. We hypothesized macrophages in the RV contribute to the RV response in PH. We induced PH i
Externí odkaz:
https://doaj.org/article/783929df348a4cba9dd4c63c25ba23b0
Publikováno v:
Pulmonary Circulation, Vol 11 (2021)
Pulmonary arterial hypertension (PAH) is a rare disorder associated with high morbidity and mortality despite currently available treatments. We compared the phosphoproteome of lung tissue from subjects with idiopathic PAH (iPAH) obtained at the time
Externí odkaz:
https://doaj.org/article/b10c7c1b697a47e4b1626811a4f66ea0
Autor:
Rahul Kumar, Michael H. Lee, Biruk Kassa, Dara C. Fonseca Balladares, Claudia Mickael, Linda Sanders, Adam Andruska, Maya Kumar, Edda Spiekerkoetter, Angela Bandeira, Kurt R. Stenmark, Rubin M. Tuder, Brian B Graham
Publikováno v:
Clinical Science. 137:617-631
Background: Pulmonary hypertension (PH) can occur as a complication of schistosomiasis. In humans, schistosomiasis-PH persists despite antihelminthic therapy and parasite eradication. We hypothesized that persistent disease arises as a consequence of
Autor:
Sue Gu, Khushboo Goel, Lindsay M. Forbes, Vitaly O. Kheyfets, Yen‐rei A. Yu, Rubin M. Tuder, Kurt R. Stenmark
Publikováno v:
Comprehensive Physiology. :4295-4319
Autor:
Michael H. Lee, Linda Sanders, Rahul Kumar, Daniel Hernandez-Saavedra, Xin Yun, Joshay A. Ford, Mario J. Perez, Claudia Mickael, Aneta Gandjeva, Daniel E. Koyanagi, Julie W. Harral, David C. Irwin, Biruk Kassa, Robert H. Eckel, Larissa A. Shimoda, Brian B. Graham, Rubin M. Tuder
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 323:L355-L371
Dysregulated metabolism characterizes both animal and human forms of pulmonary hypertension (PH). Enzymes involved in fatty acid metabolism have previously not been assessed in human pulmonary arteries affected by pulmonary arterial hypertension (PAH