Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Rubesh Raja"'
Autor:
Gaurav D. Sankhe, Rubesh Raja, Devendra Pratap Singh, Sneha Bheemireddy, Subinoy Rana, P. J. Athira, Narendra M. Dixit, Deepak Kumar Saini
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Bacterial two-component systems (TCSs) consist of a sensor histidine kinase (HK) that perceives a specific signal, and a cognate response regulator (RR) that modulates the expression of target genes. Positive autoregulation improves TCS sens
Externí odkaz:
https://doaj.org/article/f062305b2f704090bd0e7053941ff8d8
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 6, Pp 748-757 (2023)
Abstract Nonadherence is common in individuals with sickle cell disease (SCD) on hydroxyurea therapy and can be observed with waning improvements in hematologic parameters or biomarkers like mean cell volume and fetal hemoglobin level over time. We m
Externí odkaz:
https://doaj.org/article/8bb3d8e5d53948adb9939375aef6d166
Autor:
Rubesh Raja, V., Ponnusamy, Palanisamy
Publikováno v:
In Ocean Engineering 1 January 2023 267
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 1065 (2022)
Sickle cell disease (SCD) is a chronic hemolytic anemia affecting millions worldwide with acute and chronic clinical manifestations and early mortality. While hydroxyurea (HU) and other treatment strategies managed to ameliorate disease severity, hig
Externí odkaz:
https://doaj.org/article/39b5df82759249789cc8e72b009c9624
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 8, p e1008064 (2020)
Antiretroviral therapy (ART) for HIV-1 infection is life-long. Stopping therapy typically leads to the reignition of infection and progressive disease. In a major breakthrough, recent studies have shown that early initiation of ART can lead to sustai
Externí odkaz:
https://doaj.org/article/7fd34ff8fc544c6c96f0422f739e6b2d
Autor:
V., Rubesh Raja1 (AUTHOR), Palanisamy, Ponnusamy1 (AUTHOR) sreepons@gmail.com
Publikováno v:
Mechanics of Advanced Materials & Structures. Jan2024, p1-18. 18p. 12 Illustrations, 2 Charts.
Publikováno v:
PLoS Pathogens, Vol 15, Iss 4, p e1007701 (2019)
Knowledge of the within-host frequencies of resistance-associated amino acid variants (RAVs) is important to the identification of optimal drug combinations for the treatment of hepatitis C virus (HCV) infection. Multiple RAVs may exist in infected i
Externí odkaz:
https://doaj.org/article/9c61c03d1d1245588d38785bebbc7328
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 7, p e1006335 (2018)
Direct-acting antiviral agents (DAAs) for hepatitis C treatment tend to fare better in individuals who are also likely to respond well to interferon-alpha (IFN), a surprising correlation given that DAAs target specific viral proteins whereas IFN trig
Externí odkaz:
https://doaj.org/article/779f40c2c40b44dca06f51eb6b4e0be6
Autor:
Vinay Barnabas, Akanksha Kashyap, Rubesh Raja, Kapil Newar, Deepika Rai, Narendra M. Dixit, Sarika Mehra
Publikováno v:
ACS infectious diseases. 8(11)
A key mechanism driving antimicrobial resistance (AMR) stems from the ability of bacteria to up-regulate efflux pumps upon exposure to drugs. The resistance gained by this up-regulation is pliable because of the tight regulation of efflux pump levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18cc616533144276c00119e39ec9163c
https://pubmed.ncbi.nlm.nih.gov/36264222
https://pubmed.ncbi.nlm.nih.gov/36264222
Autor:
Shankar Subramaniam, Rubesh Raja, Sana Khanum, Lina Aboulmouna, Mano Ram Maurya, Ananth Grama, Doraiswami Ramkrishna, Shakti Gupta
Publikováno v:
Current Opinion in Chemical Engineering. 30:120-127
Regulation of metabolism in mammalian cells is achieved through a complex interplay between cellular signaling, metabolic reactions, and transcriptional changes. The modeling of metabolic fluxes in a cell requires the knowledge of all these mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f77fd667f765d8e24fcb462edcb05daf
https://doi.org/10.1016/j.coche.2020.100660
https://doi.org/10.1016/j.coche.2020.100660