Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Ruben Zamora"'
Autor:
Jeremy W. Cannon, Danielle S. Gruen, Ruben Zamora, Noah Brostoff, Kelly Hurst, John H. Harn, Fayten El-Dehaibi, Zhi Geng, Rami Namas, Jason L. Sperry, John B. Holcomb, Bryan A. Cotton, Jason J. Nam, Samantha Underwood, Martin A. Schreiber, Kevin K. Chung, Andriy I. Batchinsky, Leopoldo C. Cancio, Andrew J. Benjamin, Erin E. Fox, Steven C. Chang, Andrew P. Cap, Yoram Vodovotz
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-12 (2024)
Abstract Background Optimizing resuscitation to reduce inflammation and organ dysfunction following human trauma-associated hemorrhagic shock is a major clinical hurdle. This is limited by the short duration of pre-clinical studies and the sparsity o
Externí odkaz:
https://doaj.org/article/4ec280b49b694ff292ab1c9cd28a37b5
Autor:
Seth A. Schobel, Eric R. Gann, Desiree Unselt, Scott F. Grey, Felipe A. Lisboa, Meenu M. Upadhyay, Michael Rouse, Simon Tallowin, Nicholas A. Be, Xijun Zhang, Clifton L. Dalgard, Matthew D. Wilkerson, Milos Hauskrecht, Stephen F. Badylak, Ruben Zamora, Yoram Vodovotz, Benjamin K. Potter, Thomas A. Davis, Eric A. Elster
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract A combination of improved body armor, medical transportation, and treatment has led to the increased survival of warfighters from combat extremity injuries predominantly caused by blasts in modern conflicts. Despite advances, a high rate of
Externí odkaz:
https://doaj.org/article/244e583b66a54dd984daaf62225b4196
Autor:
Ashti M. Shah, Ruben Zamora, Derek Barclay, Jinling Yin, Fayten El-Dehaibi, Meghan Addorisio, Tea Tsaava, Aisling Tynan, Kevin Tracey, Sangeeta S. Chavan, Yoram Vodovotz
Publikováno v:
Frontiers in Systems Biology, Vol 4 (2024)
Introduction: The vagus nerve innervates multiple organs, but its role in regulating cross-tissue spread of inflammation is as yet unclear. We hypothesized that the vagus nerve may regulate cross-tissue inflammation via modulation of the putatively n
Externí odkaz:
https://doaj.org/article/496c8d0e4a73410d9d08b91bf0ee8b3b
Autor:
Fayten El-Dehaibi, Ruben Zamora, Josiah Radder, Jinling Yin, Ashti M. Shah, Rami A. Namas, Michelle Situ, Yanwu Zhao, William Bain, Alison Morris, Bryan J. McVerry, Derek A. Barclay, Timothy R. Billiar, Yingze Zhang, Georgios D. Kitsios, Yoram Vodovotz
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108333- (2023)
Summary: Acute inflammation is heterogeneous in critical illness and predictive of outcome. We hypothesized that genetic variability in novel, yet common, gene variants contributes to this heterogeneity and could stratify patient outcomes. We searche
Externí odkaz:
https://doaj.org/article/e6ad255c4d9d4059bc04de1506bd127e
Autor:
Ruben Zamora, Jonathan A. Forsberg, Ashti M. Shah, Desiree Unselt, Scott Grey, Felipe A. Lisboa, Timothy R. Billiar, Seth A. Schobel, Benjamin K. Potter, Eric A. Elster, Yoram Vodovotz
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Dynamic Network Analysis (DyNA) and Dynamic Hypergraphs (DyHyp) were used to define protein-level inflammatory networks at the local (wound effluent) and systemic circulation (serum) levels from 140 active-duty, injured service members (59 w
Externí odkaz:
https://doaj.org/article/23ce7451b34c491b95f17254a7e174d9
Autor:
Katherine M. Reitz, Andrew D. Althouse, Daniel E. Forman, Brian S. Zuckerbraun, Yoram Vodovotz, Ruben Zamora, Robert L. Raffai, Daniel E. Hall, Edith Tzeng
Publikováno v:
BMC Cardiovascular Disorders, Vol 23, Iss 1, Pp 1-9 (2023)
Abstract Background Peripheral artery disease (PAD) affects over 230 million people worldwide and is due to systemic atherosclerosis with etiology linked to chronic inflammation, hypertension, and smoking status. PAD is associated with walking impair
Externí odkaz:
https://doaj.org/article/af673cf65fa54a30a0ca414d9166fd84
Autor:
Ashti M. Shah, Ali Mubin Aral, Ruben Zamora, Nitin Gharpure, Fayten El-Dehaibi, Fatih Zor, Yalcin Kulahci, Huseyin Karagoz, Derek A. Barclay, Jinling Yin, Warren Breidenbach, Dmitry Tuder, Vijay S. Gorantla, Yoram Vodovotz
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionVascularized composite allotransplantation (VCA), with nerve repair/coaptation (NR) and tacrolimus (TAC) immunosuppressive therapy, is used to repair devastating traumatic injuries but is often complicated by inflammation spanning multipl
Externí odkaz:
https://doaj.org/article/c1d1411875884cb2b63df6b80b7200c0
Autor:
Rami A. Namas, Maxim Mikheev, Jinling Yin, Derek Barclay, Bahiyyah Jefferson, Qi Mi, Timothy R. Billiar, Ruben Zamora, Jorg Gerlach, Yoram Vodovotz
Publikováno v:
Frontiers in Systems Biology, Vol 2 (2023)
Introduction: Systemic acute inflammation accompanies and underlies the pathobiology of sepsis but is also central to tissue healing. We demonstrated previously the in vivo feasibility of modulating the key inflammatory mediator tumor necrosis factor
Externí odkaz:
https://doaj.org/article/087deabccc294d3aa300bcd9a3fb6b09
Autor:
Ruben Zamora, Sangeeta Chavan, Theodoros Zanos, Richard L. Simmons, Timothy R. Billiar, Yoram Vodovotz
Publikováno v:
Molecular Medicine, Vol 27, Iss 1, Pp 1-11 (2021)
Abstract Background Bacterial lipopolysaccharide (LPS) induces a multi-organ, Toll-like receptor 4 (TLR4)-dependent acute inflammatory response. Methods Using network analysis, we defined the spatiotemporal dynamics of 20, LPS-induced, protein-level
Externí odkaz:
https://doaj.org/article/661d12bce8a244c99e15f56f6542a73d
Autor:
Nabil Azhar, Rami A. Namas, Khalid Almahmoud, Akram Zaaqoq, Othman A. Malak, Derek Barclay, Jinling Yin, Fayten El-Dehaibi, Andrew Abboud, Richard L. Simmons, Ruben Zamora, Timothy R. Billiar, Yoram Vodovotz
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Systemic inflammation is complex and likely drives clinical outcomes in critical illness such as that which ensues following severe injury. We obtained time course data on multiple inflammatory mediators in the blood of blunt trauma patients
Externí odkaz:
https://doaj.org/article/eaee90484a5b42d6b93c66d1d070bc50